Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 60/100

Failure Rate

6.3%

1 terminated/withdrawn out of 16 trials

Success Rate

75.0%

-11.6% vs industry average

Late-Stage Pipeline

13%

2 trials in Phase 3/4

Results Transparency

0%

0 of 3 completed trials have results

Key Signals

8 recruiting

Enrollment Performance

Analytics

Phase 1
10(62.5%)
Phase 2
4(25.0%)
Phase 3
2(12.5%)
16Total
Phase 1(10)
Phase 2(4)
Phase 3(2)

Activity Timeline

Global Presence

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Clinical Trials (16)

Showing 16 of 16 trials
NCT07784374Phase 2Recruiting

A Phase II Study of GFH375 Combined With GFS202A or GFH276 Versus GFH375 in Patients With Previously Treated Locally Advanced Unresectable or Metastatic Pancreatic Cancer Harboring KRAS G12D Mutation

Role: lead

NCT07846358Phase 1Not Yet Recruiting

This is a Multicenter, Open-label, Phase I/II Study to Explore the Safety, Tolerability, Pharmacokinetics (PK), and Preliminary Efficacy of GFH276 in Patients With Advanced NSCLC Harboring a RAS Mutation.

Role: lead

NCT07262567Phase 3Recruiting

Phase III Study to Compare GFH375 and Chemotherapy in Patients With KRAS G12D-Mutant Metastatic Pancreatic Cancer

Role: lead

NCT07668752Phase 3Recruiting

A Study to Evaluate GFH375 Versus Docetaxel in Participants With Non-Small Cell Lung Cancer With KRAS G12D Mutation

Role: lead

NCT07678593Phase 1Not Yet Recruiting

A Study of GFH276 Combined With Cetuximab or Chemotherapy in Participants With Solid Tumors and Pancreatic Ductal Adenocarcinoma (PDAC) Harboring RAS Mutation

Role: lead

NCT07554859Phase 2Not Yet Recruiting

GFH375 Monotherapy and Combination Therapy as First-Line Treatment for Advanced KRAS G12D-Mutant Non-Small Cell Lung Cancer

Role: lead

NCT07259590Phase 1Recruiting

A Study of GFH375 Combined With Cetuximab or Chemotherapy in Participants With Solid Tumors Harboring KRAS G12D Mutation

Role: lead

NCT06500676Phase 1Recruiting

A Study of GFH375 in Patients With Advanced Solid Tumors With KRAS G12D Mutations

Role: lead

NCT07026916Phase 2Withdrawn

A Phase II Study to Evaluate GFH375 in Patients With KRAS G12D Mutant Metastatic Pancreatic Cancer

Role: lead

NCT05386888Phase 2Completed

A Trial of GFH018 and Toripalimab in Combination With Concurrent Chemoradiotherapy in Stage III NSCLC Chemoradiotherapy in Stage III NSCLC

Role: lead

NCT07198321Phase 1Not Yet Recruiting

A Single-Arm, Open-Label, Multicenter Phase I/II Clinical Study of GFH276 in Patients With RAS-Mutant Advanced Solid Tumors

Role: lead

NCT06375733Phase 1Recruiting

A Study of GFH009 in Combination With Zanubrutinib in Subjects With Relapsed or Refractory DLBCL

Role: lead

NCT05756153Phase 1Completed

A Study of GFH925 in Combination With Cetuximab in Previously Untreated Advanced NSCLC Harboring KRAS G12C Mutation

Role: lead

NCT06898255Phase 1Recruiting

A Phase I Study to Evaluate GFS202A in Advanced Solid Tumor Patients With Pre-cachexia or Cachexia

Role: lead

NCT04914286Phase 1Completed

A Study of GFH018 in Combination With Toripalimab in Patients With Advanced Solid Tumors

Role: lead

NCT05934513Phase 1Recruiting

A Study of GFH009 Monotherapy in Patients with Relapsed or Refractory Peripheral T-cell Lymphoma (PTCL)

Role: lead

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