Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 75/100

Failure Rate

22.7%

5 terminated/withdrawn out of 22 trials

Success Rate

73.7%

-12.8% vs industry average

Late-Stage Pipeline

5%

1 trials in Phase 3/4

Results Transparency

14%

2 of 14 completed trials have results

Key Signals

1 recruiting2 with results5 withdrawn

Enrollment Performance

Analytics

Phase 1
18(85.7%)
Phase 2
2(9.5%)
Phase 3
1(4.8%)
21Total
Phase 1(18)
Phase 2(2)
Phase 3(1)

Activity Timeline

Global Presence

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Clinical Trials (22)

Showing 20 of 22 trials
NCT07385638Phase 2Not Yet Recruiting

Olorofim in Early Coccidioidal Meningitis

Role: collaborator

NCT05101187Phase 3Active Not Recruiting

Olorofim Aspergillus Infection Study

Role: lead

NCT03583164Phase 2Completed

Evaluate F901318 (Olorofim) Treatment of Invasive Fungal Infections in Participants Lacking Treatment Options

Role: lead

NCT01731353Recruiting

FungiScope - A Global Emerging Fungal Infection Registry

Role: collaborator

NCT05200286Phase 1Completed

A Phase I Study to Assess the Pharmacokinetics of Olorofim in Subjects With Renal Impairment

Role: lead

NCT04752540Phase 1Completed

A Phase I Study to Assess the Pharmacokinetics of Olorofim in Subjects With Hepatic Impairment

Role: lead

NCT04207957Phase 1Completed

A Biopharmaceutics Study to Assess the Pharmacokinetics of Single Oral and IV Doses of Olorofim

Role: lead

NCT04171739Phase 1Completed

Drug-drug Interaction (DDI) Study to Assess Effect of Itraconazole and Rifampicin Upon Olorofim

Role: lead

NCT04039880Phase 1Completed

Absorption, Metabolism and Excretion of 14C-olorofim in Man

Role: lead

NCT02912026Phase 1Withdrawn

Radiolabelled IV and Oral Metabolism Study of F901318

Role: lead

NCT03340597Phase 1Completed

Assessment of Varying Oral Dosing Regimens for F901318 in Healthy Subjects

Role: lead

NCT03036046Phase 1Withdrawn

Safety and Pharmacokinetics of Oral F901318 (Fluconazole and Posaconazole) IN Aml Leukaemia

Role: lead

NCT02856178Phase 1Withdrawn

Study on Safety and Pharmacokinetics of Intravenous F901318 for Fungal Prophylaxis in AML Patients

Role: lead

NCT03095547Phase 1Withdrawn

Drug/Drug Interactions With F901318

Role: lead

NCT03076905Phase 1Withdrawn

Pharmacokinetics of IV Formulation

Role: lead

NCT02737371Phase 1Completed

Multiple Ascending Oral Dose Study of F901318 in Healthy Subjects

Role: lead

NCT02730442Phase 1Completed

Study of Potential for Interaction of Fluconazole With F901318

Role: lead

NCT02808741Phase 1Completed

Evaluation of Immediate Release Tablet

Role: lead

NCT02394483Phase 1Completed

Single Ascending Oral Dose Study of F901318

Role: lead

NCT02342574Phase 1Completed

F901318 Multiple Ascending Dose Study

Role: lead