Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 90/100

Failure Rate

31.3%

5 terminated/withdrawn out of 16 trials

Success Rate

58.3%

-28.2% vs industry average

Late-Stage Pipeline

13%

2 trials in Phase 3/4

Results Transparency

71%

5 of 7 completed trials have results

Key Signals

2 recruiting5 with results

Enrollment Performance

Analytics

Phase 1
7(46.7%)
Phase 2
6(40.0%)
Phase 3
2(13.3%)
15Total
Phase 1(7)
Phase 2(6)
Phase 3(2)

Activity Timeline

Global Presence

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Clinical Trials (16)

Showing 16 of 16 trials
NCT02489903Phase 2Completed

RRx-001 in Lung Cancer, Ovarian Cancer and Neuroendocrine Tumors Prior to Re-administration of Platinum Based Doublet Regimens (QUADRUPLE THREAT)

Role: lead

NCT05966194Phase 2Recruiting

RRx-001 for Reducing Oral Mucositis in Patients Receiving Chemotherapy and Radiation for Head and Neck Cancer

Role: lead

NCT03515538Phase 2Completed

Safety and Efficacy of RRx-001 in the Attenuation of Oral Mucositis in Patients Receiving Chemoradiation for the Treatment of Oral Cancers

Role: lead

NCT01359982Phase 1Completed

Safety and Pharmacokinetic Study of RRx-001 in Cancer Subjects

Role: lead

NCT04525014Phase 1Terminated

RRx-001 Given With Irinotecan and Temozolomide for Pediatric Patients With Recurrent or Progressive Malignant Solid and Central Nervous System Tumors

Role: lead

NCT05566041Phase 3Active Not Recruiting

A Phase 3, Controlled, Open-label, Global Randomized Study of RRx-001 With a Platinum Doublet or a Platinum Doublet in Small Cell Lung Cancer

Role: lead

NCT04673942Phase 2Recruiting

A Study of AdAPT-001 in Subjects With Sarcoma and Refractory Solid Tumors

Role: lead

NCT02096354Phase 2Completed

A Phase 2 Randomized, Open-Label Study of RRx-001 vs Regorafenib in Subjects With Metastatic Colorectal Cancer

Role: lead

NCT02452970Phase 2Terminated

RRx-001 in Second Line Treatment of Advanced Cholangiocarcinoma Prior to Readministration of First-Line Therapy

Role: lead

NCT03699956Phase 3Terminated

RRx-001 Sequentially With a Platinum Doublet or a Platinum Doublet in Third-Line or Beyond in Patients With Small Cell Lung Cancer

Role: lead

NCT02801097Phase 1Terminated

RRx-001 in Combination With Irinotecan in Metastatic or Advanced Cancer (PAYLOAD)

Role: lead

NCT02871843Phase 1Completed

RRx-001 + Radiation + Temozolomide In Newly Diagnosed Glioblastoma and Anaplastic Gliomas

Role: lead

NCT02215512Phase 1Completed

Dose-Escalation Study of RRx-001 in Combination With Whole Brain Radiation in Subjects With Brain Metastases

Role: lead

NCT02518958Phase 1Completed

A Phase I, Open-Label, Multiple Ascending Dose Study of RRx-001 and Nivolumab

Role: lead

NCT03529539Unknown

Expanded Access for PSV Personalized Oncolytic Viruses

Role: lead

NCT02096341Phase 1Terminated

A Phase 1 Pilot Study of the Subcutaneous (s.c.) Route to Facilitate the Administration of RRx-001

Role: lead

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