Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 75/100

Failure Rate

15.4%

2 terminated/withdrawn out of 13 trials

Success Rate

60.0%

-26.5% vs industry average

Late-Stage Pipeline

23%

3 trials in Phase 3/4

Results Transparency

0%

0 of 3 completed trials have results

Key Signals

4 recruiting

Enrollment Performance

Analytics

Phase 2
7(63.6%)
Phase 3
3(27.3%)
Phase 1
1(9.1%)
11Total
Phase 2(7)
Phase 3(3)
Phase 1(1)

Activity Timeline

Global Presence

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Clinical Trials (13)

Showing 13 of 13 trials
NCT07281924Phase 1Recruiting

Hepzato Kit and Opdualag for Metastatic Melanoma and Liver Metastasis

Role: collaborator

NCT07276386Phase 2Recruiting

Phase 2 Combination of Melphalan/HDS Via PHP + Tebentafusp in Treating Metastatic Uveal Melanoma

Role: collaborator

NCT06875128Phase 2Recruiting

Evaluation of the Safety and Efficacy of Treatment w/High Dose Melphalan Given Directly Into the Liver Followed by Treatment w/Approved Cancer Treatment or Approved Cancer Treatment Alone in Patients w/ Metastatic Breast Cancer w/Liver Dominant Disease

Role: lead

NCT06607458Phase 2Recruiting

Evaluation of the Safety and Efficacy of Treatment w/High Dose Melphalan Given Directly Into the Liver Followed by Treatment w/Approved Cancer Treatment or Approved Cancer Treatment Alone in Patients w/ Metastatic Colorectal Cancer w/Liver Dominant Disease

Role: lead

NCT05022901Phase 3Unknown

An Open-Label Expanded Access Study of the Melphalan/Hepatic Delivery System (HDS) in Patients With Hepatic Dominant Ocular Melanoma

Role: lead

NCT02678572Phase 3Completed

Percutaneous Hepatic Perfusion in Patients With Hepatic-dominant Ocular Melanoma

Role: lead

NCT02415036Phase 2Terminated

Melphalan for Use With the Hepatic Delivery System Treatment in Patients With Unresectable Hepatocellular Carcinoma or Intra Hepatic Cholangiocarcinoma

Role: lead

NCT03086993Phase 2Unknown

Percutaneous Hepatic Perfusion vs. Cisplatin/Gemcitabine in Patients With Intrahepatic Cholangiocarcinoma

Role: lead

NCT00324727Phase 3Completed

Hepatic Arterial Infusion With Melphalan Compared With Standard Therapy in Treating Patients With Unresectable Liver Metastases Due to Melanoma

Role: lead

NCT03266042Unknown

Registry Protocol- Melphalan Percutaneous Hepatic Perfusion for the Treatment of Unresectable Hepatic Malignancy

Role: lead

NCT02406508Phase 2Withdrawn

Sequential Melphalan for Use With Hepatic Delivery System Treatment Followed by Sorafenib in Patients With Unresectable HCC

Role: lead

NCT00096083Phase 2Completed

Hepatic Arterial Infusion of Melphalan With Hepatic Perfusion in Treating Patients With Unresectable Liver Cancer

Role: lead

NCT01728051Unknown

Expanded Access Study of Melphalan With Delcath CS-PHP System in Patients With Ocular/Cutaneous Melanoma Mets to Liver

Role: lead

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