Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 70/100

Failure Rate

26.9%

7 terminated/withdrawn out of 26 trials

Success Rate

46.2%

-40.4% vs industry average

Late-Stage Pipeline

23%

6 trials in Phase 3/4

Results Transparency

83%

5 of 6 completed trials have results

Key Signals

7 recruiting5 with results6 terminated

Enrollment Performance

Analytics

Phase 1
17(70.8%)
Phase 3
6(25.0%)
Phase 2
1(4.2%)
24Total
Phase 1(17)
Phase 3(6)
Phase 2(1)

Activity Timeline

Global Presence

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Clinical Trials (26)

Showing 20 of 26 trials
NCT07539090Phase 1Recruiting

Evaluate the Effect of Vimseltinib on Pharmacokinetics of Combined Oral Contraceptive (Ethinyl Estradiol/Levonorgestrel)

Role: lead

NCT05957367Phase 1Recruiting

A Study of Inlexisertib (DCC-3116) in Combination With Anticancer Therapies in Participants With Advanced Malignancies

Role: lead

NCT07104032Phase 3Recruiting

IGNITE: Study of Tirabrutinib vs Rituximab/Temozolomide for Relapsed/Refractory Primary Central Nervous System Lymphoma (PCNSL)

Role: collaborator

NCT06966024Phase 1Recruiting

Study of DCC-2812 in Participants With Advanced Genitourinary Cancers

Role: lead

NCT04892017Phase 1Terminated

Study of Inlexisertib (DCC-3116) in Participants With RAS/MAPK Pathway Mutant Solid Tumors

Role: lead

NCT05059262Phase 3Active Not Recruiting

Study of Vimseltinib for Tenosynovial Giant Cell Tumor

Role: lead

NCT06287463Phase 1Terminated

Study of DCC-3084 in Participants With Advanced Malignancies Driven by the Mitogen-Activated Protein Kinase (MAPK) Pathway

Role: lead

NCT07429266Phase 3Not Yet Recruiting

A Study of Sapablursen Evaluating the Safety and Efficacy in Participants With Polycythemia Vera (PV)

Role: collaborator

NCT07158411Phase 1Completed

Evaluate the Effect of Vimseltinib on Organic Cation Transporter 2 (OCT2)

Role: lead

NCT06630234Phase 1Recruiting

A Master Protocol to Evaluate DCC-3009 in Gastrointestinal Stromal Tumor (GIST)

Role: lead

NCT03673501Phase 3Active Not Recruiting

A Study of Ripretinib vs Sunitinib in Advanced GIST Patients After Treatment With Imatinib

Role: lead

NCT07158398Phase 1Completed

Evaluate the Effect of Vimseltinib on the Pharmacokinetics of a BCRP and OATP1B1 Substrate

Role: lead

NCT03069469Phase 1Active Not Recruiting

Study of Vimseltinib (DCC-3014) in Patients With Advanced Tumors and Tenosynovial Giant Cell Tumor

Role: lead

NCT05734105Phase 3Active Not Recruiting

A Study of Ripretinib vs Sunitinib in Patients With Advanced GIST With Specific KIT Exon Mutations Who Were Previously Treated With Imatinib

Role: lead

NCT06619561Phase 2Recruiting

A Study to Evaluate Vimseltinib in Adults With Active Chronic Graft-Versus-Host Disease (cGVHD)

Role: lead

NCT07075471Recruiting

Tenosynovial Giant Cell Tumor (TGCT) Real-World Participant Experience With Vimseltinib

Role: lead

NCT03717415Phase 1Terminated

A Study of Rebastinib (DCC-2036) in Combination With Carboplatin in Patients With Advanced or Metastatic Solid Tumors

Role: lead

NCT03601897Phase 1Terminated

A Phase 1b/2 Study of Rebastinib (DCC-2036) in Combination With Paclitaxel in Patients With Advanced or Metastatic Solid Tumors

Role: lead

NCT04530981Phase 1Completed

A Drug-Drug Interaction Study to Evaluate the Effect of Ripretinib on the Pharmacokinetics of a CYP2C8 Probe Substrate in Patients with Advanced GIST

Role: lead

NCT02571036Phase 1Completed

A Safety, Tolerability and PK Study of DCC-2618 in Patients With Advanced Malignancies

Role: lead