Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Moderate Risk

Score: 55/100

Failure Rate

25.0%

14 terminated/withdrawn out of 56 trials

Success Rate

68.9%

-17.6% vs industry average

Late-Stage Pipeline

16%

9 trials in Phase 3/4

Results Transparency

58%

18 of 31 completed trials have results

Key Signals

6 recruiting18 with results12 terminated

Enrollment Performance

Analytics

Phase 1
29(51.8%)
Phase 2
13(23.2%)
Phase 3
9(16.1%)
N/A
5(8.9%)
56Total
Phase 1(29)
Phase 2(13)
Phase 3(9)
N/A(5)

Activity Timeline

Global Presence

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Clinical Trials (56)

Showing 20 of 56 trials
NCT05815160Phase 1Terminated

Debio 0123 in Combination With Carboplatin and Etoposide in Adult Participants With Small Cell Lung Cancer That Recurred or Progressed After Previous Standard Platinum-Based Therapy

Role: lead

NCT07035769Phase 1Recruiting

A First-in-Human Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Single and Multiple Oral Doses of Debio 1453P in Healthy Adults

Role: lead

NCT06129539Phase 3Active Not Recruiting

A Study to Assess the Efficacy, Safety, and Pharmacokinetics of Debio 4326 in Pediatric Participants With Central Precocious Puberty (LIBELULA™ Clinical Trial)

Role: lead

NCT06930625Phase 3Recruiting

A Study to Assess the Efficacy and Safety of Debio 4126 in Participants With Acromegaly Previously Treated With Somatostatin Analogs

Role: lead

NCT05109975Phase 1Active Not Recruiting

A Study to Evaluate Safety and Preliminary Anti-tumor Activity of Debio 0123 as Monotherapy in Adult Participants With Advanced Solid Tumors

Role: lead

NCT06395753Phase 2Active Not Recruiting

A Dose Finding Study of Debio 4228 in Participants With Advanced Prostate Cancer

Role: lead

NCT05765812Phase 1Recruiting

A Study of Debio 0123 in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Debio 0123 in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed Glioblastoma

Role: lead

NCT04855656Phase 1Recruiting

Study of Lunresertib Alone or in Combination With RP-3500 or Debio 0123 in Patients With Advanced Solid Tumors

Role: lead

NCT06969430Phase 1Recruiting

A Study to Assess the Safety, Tolerability, and Antileukemic Activity of Debio 1562M in Participants With Acute Myeloid Leukemia (AML)

Role: lead

NCT05746806Not ApplicableActive Not Recruiting

Trial of Ultrahypofractionated Focal Salvage Radiotherapy for Isolated Prostate Bed Recurrence After Radical Prostatectomy

Role: collaborator

NCT06612203Phase 1Active Not Recruiting

Clinical Study to Evaluate Debio0123 + Sacituzumab Govitecan Combination in TNBC or HR+/HER2- Advanced Breast Cancer

Role: collaborator

NCT05147272Phase 1Terminated

Study of RP-6306 With Gemcitabine in Advanced Solid Tumors

Role: lead

NCT05147350Phase 1Terminated

Study of RP-6306 With FOLFIRI in Advanced Solid Tumors

Role: lead

NCT03968653Phase 1Terminated

Study of Oral Debio 0123 in Combination With Carboplatin in Participants With Advanced Solid Tumors

Role: lead

NCT03723551Phase 2Terminated

Study to Assess Safety, Tolerability and Efficacy of Afabicin in The Treatment of Participants With Bone or Joint Infection Due to Staphylococcus

Role: lead

NCT05364944Phase 1Terminated

A Study to Assess the Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Debio 4126 in Participants With Acromegaly or Functioning Gastroenteropancreatic Neuroendocrine Tumors (GEP-NETs)

Role: lead

NCT06225284Phase 2Recruiting

Neoadjuvant Chemotherapy With or Without GnRH Agonist for Premenopausal Triple-negative Early Breast Cancer Patients

Role: collaborator

NCT02564744Phase 2Completed

Study to Evaluate the Efficacy and Tolerability of Debio 1562 in Combination With Rituximab in Participants With Relapsed and/or Refractory DLBCL and Other Forms of NHL

Role: lead

NCT03834220Phase 2Terminated

Basket Trial in Solid Tumors Harboring a Fusion of FGFR1, FGFR2 or FGFR3- (FUZE Clinical Trial)

Role: lead

NCT04122625Phase 1Completed

Study to Assess Safety and Efficacy of the Second Mitochondrial-derived Activator of Caspases (SMAC) Mimetic Debio 1143

Role: lead