Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 100/100

Failure Rate

35.0%

7 terminated/withdrawn out of 20 trials

Success Rate

53.3%

-33.2% vs industry average

Late-Stage Pipeline

5%

1 trials in Phase 3/4

Results Transparency

38%

3 of 8 completed trials have results

Key Signals

1 recruiting3 with results7 terminated

Enrollment Performance

Analytics

Phase 1
12(60.0%)
Phase 2
6(30.0%)
Early Phase 1
1(5.0%)
Phase 3
1(5.0%)
20Total
Phase 1(12)
Phase 2(6)
Early Phase 1(1)
Phase 3(1)

Activity Timeline

Global Presence

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Clinical Trials (20)

Showing 20 of 20 trials
NCT03641755Phase 1Active Not Recruiting

Olaparib + Sapacitabine in BRCA Mutant Breast Cancer

Role: collaborator

NCT02649751Phase 2Terminated

Evaluation of (R)-Roscovitine Safety and Effects in Subjects With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation

Role: collaborator

NCT05817890Early Phase 1Completed

Absorption, Metabolism, and Excretion of CYC065 in Healthy Male Subjects

Role: lead

NCT04017546Phase 1Completed

CYC065 CDK Inhibitor and Venetoclax Study in Relapsed/Refractory AML or MDS

Role: lead

NCT03884829Phase 1Terminated

A Phase I Study of CYC140, a PLK-1 Inhibitor, in Advanced Leukemias or MDS

Role: lead

NCT00590187Phase 2Completed

Efficacy Study of Oral Sapacitabine to Treat Acute Myeloid Leukemia in Elderly Patients

Role: lead

NCT02552953Phase 1Completed

A Pharmacologic Study of CYC065, a Cyclin Dependent Kinase Inhibitor, in Patients With Advanced Cancers

Role: lead

NCT05168904Phase 1Suspended

A Study to Investigate Fadraciclib (CYC065), in Subjects With Leukemia or Myelodysplastic Syndrome (MDS)

Role: lead

NCT05358379Phase 1Recruiting

A Study to Investigate CYC140, in Subjects With Advanced Solid Tumors and Lymphoma

Role: lead

NCT03739554Phase 1Completed

CYC065 CDK Inhibitor and Venetoclax Study in Relapsed/Refractory CLL

Role: lead

NCT04983810Phase 1Unknown

A Study to Investigate Fadraciclib (CYC065), in Subjects With Advanced Solid Tumors and Lymphoma

Role: lead

NCT01303796Phase 3Completed

A Study of Oral Sapacitabine in Elderly Patients With Newly Diagnosed Acute Myeloid Leukemia

Role: lead

NCT00999401Phase 1Completed

A Study of Oral Sapacitabine and Oral Seliciclib in Patients With Advanced Solid Tumors

Role: lead

NCT00372073Phase 2Terminated

Efficacy Study of Oral Seliciclib to Treat Non-Small Cell Lung Cancer

Role: lead

NCT00476554Phase 2Terminated

A Randomized Phase II Study of Oral Sapacitabine in Patients With Advanced Cutaneous T-cell Lymphoma

Role: lead

NCT00885963Phase 2Terminated

A Study of Oral Sapacitabine in Patients With Previously Treated Non-Small Cell Lung Cancer

Role: lead

NCT00560716Phase 1Terminated

A Phase I Pharmacologic Study of CYC116, an Oral Aurora Kinase Inhibitor, in Patients With Advanced Solid Tumors

Role: lead

NCT00380653Phase 1Completed

Safety and Pharmacology Study of Sapacitabine to Treat Advanced Leukemias or Myelodysplastic Syndromes

Role: lead

NCT01253460Phase 2Terminated

Sapacitabine, Cyclophosphamide, Rituximab for Relapsed Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma (CLL/SLL) With Deletion (11q22-23)

Role: collaborator

NCT01211457Phase 1Unknown

Study of Sapacitabine in Acute Myeloid Leukemia (AML) or Myelodysplastic Syndromes (MDS)

Role: lead

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