Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Moderate Risk

Score: 50/100

Failure Rate

28.1%

25 terminated/withdrawn out of 89 trials

Success Rate

71.9%

-14.6% vs industry average

Late-Stage Pipeline

51%

45 trials in Phase 3/4

Results Transparency

80%

51 of 64 completed trials have results

Key Signals

51 with results25 terminated

Enrollment Performance

Analytics

Phase 3
27(31.8%)
Phase 2
23(27.1%)
Phase 4
18(21.2%)
Phase 1
12(14.1%)
N/A
4(4.7%)
Early Phase 1
1(1.2%)
85Total
Phase 3(27)
Phase 2(23)
Phase 4(18)
Phase 1(12)
+2 more

Activity Timeline

Global Presence

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Clinical Trials (89)

Showing 20 of 89 trials
NCT01216540Completed

Vancomycin-Associated Nephrotoxicity

Role: collaborator

NCT01598311Phase 3Completed

A Study of CB-183,315 in Participants With Clostridium Difficile Associated Diarrhea (MK-4261-006)

Role: lead

NCT00261807Not ApplicableCompleted

Daptomycin for the Treatment of Severe Necrotizing Soft-Tissue Infections

Role: collaborator

NCT00467272Phase 2Completed

Catheter Related - Gram Positive Bloodstream Infections

Role: collaborator

NCT00638157Phase 4Terminated

Phase 4 Efficacy and Safety Study of Cubicin® With and Without Combination Therapy in S. Aureus Infective Endocarditis (SAIE)

Role: lead

NCT02421120Phase 4Completed

Population Pharmacokinetics and Safety of Intravenous Ceftolozane/Tazobactam in Adult Cystic Fibrosis Patients

Role: collaborator

NCT02070757Phase 3Completed

Safety and Efficacy Study of Ceftolozane/Tazobactam to Treat Ventilated Nosocomial Pneumonia (MK-7625A-008)

Role: lead

NCT00136292Phase 1Completed

Study of Single Dose Daptomycin in Pediatric Patients With Gram-positive Infection for Which They Are Receiving Standard Antibiotics

Role: lead

NCT01775397Phase 4Terminated

A Post-marketing, Blinded Study to Investigate How Effective Fidaxomicin is Compared to Vancomycin in the Sustained Cure of Clostridium Difficile Infection in Adults That Are Receiving Therapy to Suppress the Immune System

Role: collaborator

NCT00540072Phase 3Completed

Study of Cidecin™ (Daptomycin) to Rocephin® (Ceftriaxone) in the Treatment of Moderate to Severe Community-Acquired Acute Bacterial Pneumonia Due to S. Pneumoniae

Role: lead

NCT00538694Phase 3Completed

Comparative Study of Cidecin™ (Daptomycin) to Rocephin® (Ceftriaxone) in the Treatment of Moderate to Severe Community-Acquired Acute Bacterial Pneumonia

Role: lead

NCT01019395Phase 1Completed

Pharmacokinetics (PK) and Safety Evaluation of Daptomycin in Children Ages 3-24 Months With Proven or Suspected Gram-positive Infections or Peri-Operative Subjects Receiving Prophylactic Antibiotics

Role: lead

NCT00679835Phase 1Completed

PK and Safety Evaluation of Daptomycin in Children Ages 2-6 With Proven or Suspected Gram-positive Infections

Role: lead

NCT02266706Phase 1Completed

Pharmacokinetic and Safety Study of Ceftolozane/Tazobactam in Pediatric Participants Receiving Antibiotic Therapy for Proven or Suspected Gram-negative Infection or for Peri-operative Prophylaxis (MK-7625A-010)

Role: lead

NCT02387372Phase 1Completed

Plasma Pharmacokinetics (PK) & Lung Penetration of Ceftolozane/Tazobactam in Participants With Pneumonia (MK-7625A-007)

Role: lead

NCT02276482Phase 3Completed

Study of Tedizolid Phosphate in Adolescents With Complicated Skin and Soft Tissue Infection (cSSTI) (MK-1986-012)

Role: lead

NCT01597505Phase 3Completed

Study of CB-183,315 in Participants With Clostridium Difficile Associated Diarrhea (MK-4261-005)

Role: lead

NCT02019420Phase 3Completed

Tedizolid Phosphate (TR-701 FA, MK-1986) vs Linezolid for the Treatment of Nosocomial Pneumonia (MK-1986-002)

Role: lead

NCT00448864Phase 2Terminated

Efficacy Study of Recombinant Protein (Ecallantide) to Reduce Blood Loss During Primary Coronary Bypass Grafting or Valve Repair/Replacement

Role: lead

NCT02341599Phase 1Completed

Study of Pharmacokinetics of a Single IV Dose of CB-238,618 in Subjects With Varying Degrees of Renal Impairment Compared to Healthy Subjects (MK-6183-001)

Role: lead