Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 80/100

Failure Rate

66.7%

10 terminated/withdrawn out of 15 trials

Success Rate

28.6%

-57.9% vs industry average

Late-Stage Pipeline

0%

0 trials in Phase 3/4

Results Transparency

150%

6 of 4 completed trials have results

Key Signals

6 with results9 terminated

Enrollment Performance

Analytics

Phase 1
10(66.7%)
Phase 2
5(33.3%)
15Total
Phase 1(10)
Phase 2(5)

Activity Timeline

Global Presence

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Clinical Trials (15)

Showing 15 of 15 trials
NCT00867568Phase 1Completed

TPI 287 in Patients With Refractory or Recurrent Neuroblastoma or Medulloblastoma

Role: collaborator

NCT01483820Phase 1Terminated

Safety and Efficacy Study of TPI-287 in Neuroblastoma and Medulloblastoma

Role: collaborator

NCT01505608Phase 1Terminated

Randomized Efficacy Study of TPI 287 to Treat Primary Refractory or Early Relapsed Neuroblastoma

Role: collaborator

NCT01933815Phase 1Suspended

Dose-Escalation Study of TPI 287 + Avastin Followed by Randomized Study of the Same Versus Avastin for Glioblastoma

Role: lead

NCT02187822Phase 1Terminated

Fractionated Stereotactic Radiotherapy (FSRT) in Treatment of Brain Metastases

Role: collaborator

NCT01582152Phase 1Terminated

Phase I/II Bevacizumab Versus Bevacizumab Plus TPI 287 for Recurrent Glioblastoma

Role: collaborator

NCT01332630Phase 2Completed

TPI 287 in Breast Cancer Metastatic to the Brain

Role: collaborator

NCT02047214Phase 2Terminated

Safety & Efficacy Study of TPI 287 + Avastin in Adults With Glioblastoma That Progressed Following Prior Avastin Therapy

Role: lead

NCT01067066Phase 1Terminated

A Phase I Study of TPI 287 - Temozolomide Combination in Melanoma

Role: collaborator

NCT01113463Phase 2Terminated

TPI 287 in Patients With Recurrent Glioblastoma Multiforme

Role: collaborator

NCT00479635Phase 2Terminated

A Phase II Trial of TPI 287 in Patients With Metastatic Prostate Cancer

Role: lead

NCT00553813Phase 2Terminated

A Phase II Trial of TPI 287 in Patients Advanced, Unresectable Pancreatic Cancer

Role: lead

NCT01340729Phase 1Withdrawn

Open-Label Study of TPI 287 for Patients With Metastatic Melanoma

Role: collaborator

NCT00113724Phase 1Completed

Study of TPI 287 in Patients With Advanced Malignancies

Role: lead

NCT00256191Phase 1Completed

Study of TPI 287 Administered Every 21 Days in Patients With Advanced Malignancies

Role: lead

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