Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 75/100

Failure Rate

15.4%

2 terminated/withdrawn out of 13 trials

Success Rate

77.8%

-8.7% vs industry average

Late-Stage Pipeline

0%

0 trials in Phase 3/4

Results Transparency

43%

3 of 7 completed trials have results

Key Signals

3 with results

Enrollment Performance

Analytics

Phase 2
9(90.0%)
Phase 1
1(10.0%)
10Total
Phase 2(9)
Phase 1(1)

Activity Timeline

Global Presence

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Clinical Trials (13)

Showing 13 of 13 trials
NCT05281484Unknown

Two Intermediate Expanded Access Protocols (EAP) CNMAu8.EAP01 and CNMAu8.EAP02 for ALS

Role: lead

NCT04081714Unknown

Intermediate Expanded Access Protocol CNMAu8.EAP03

Role: lead

NCT03993171Phase 2Completed

31P-MRS Imaging to Assess the Effects of CNM-Au8 on Impaired Neuronal Redox State in Multiple Sclerosis.

Role: lead

NCT05299658Phase 2Active Not Recruiting

An Open-Label Extension for the Phase 2 Study in Early Symptomatic Amyotrophic Lateral Sclerosis Patients on Stable Background Therapy to Assess Bioenergetic Catalysis With CNM-Au8 to Slow Disease Progression in ALS

Role: lead

NCT06408727Unknown

Intermediate Expanded Access Protocol CNMAu8.EAP04

Role: lead

NCT04098406Phase 2Completed

Therapeutic Nanocatalysis to Slow Disease Progression of Amyotrophic Lateral Sclerosis (ALS)

Role: lead

NCT03815916Phase 2Completed

31P-MRS Imaging to Assess the Effects of CNM-Au8 on Impaired Neuronal Redox State in Parkinson's Disease

Role: lead

NCT04626921Phase 2Completed

A Multi-Center, Open-Label Long-Term Extension Study of CNM-Au8 In Patients With Stable Relapsing Multiple Sclerosis

Role: lead

NCT04414345Phase 2Completed

HEALEY ALS Platform Trial - Regimen C CNM-Au8

Role: collaborator

NCT04610138Phase 2Completed

Study of ZnAg Liquid Solution to Treat COVID-19 Symptomatic Participants

Role: lead

NCT03843710Phase 2Withdrawn

31P-MRS Imaging to Assess the Effects of CNM-Au8 on Impaired Neuronal Redox State in Amyotrophic Lateral Sclerosis (REPAIR-ALS)

Role: lead

NCT03536559Phase 2Terminated

Nanocrystalline Gold to Treat Remyelination Failure in Chronic Optic Neuropathy In Multiple Sclerosis

Role: lead

NCT02755870Phase 1Completed

A Phase I SAD and MAD Clinical Trial of CNM-Au8 in Healthy Male and Female Volunteers

Role: lead

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