Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 75/100

Failure Rate

24.6%

17 terminated/withdrawn out of 69 trials

Success Rate

67.9%

-18.6% vs industry average

Late-Stage Pipeline

7%

5 trials in Phase 3/4

Results Transparency

33%

12 of 36 completed trials have results

Key Signals

6 recruiting12 with results16 terminated

Enrollment Performance

Analytics

Phase 1
43(64.2%)
Phase 2
18(26.9%)
Phase 3
5(7.5%)
Early Phase 1
1(1.5%)
67Total
Phase 1(43)
Phase 2(18)
Phase 3(5)
Early Phase 1(1)

Activity Timeline

Global Presence

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Clinical Trials (69)

Showing 20 of 69 trials
NCT06727552Phase 2Active Not Recruiting

A Study of Barzolvolimab in Patients With Atopic Dermatitis

Role: lead

NCT06650761Phase 1Completed

A Phase I Study of CDX-622

Role: lead

NCT07256392Phase 3Recruiting

Long-term Efficacy and Safety Extension (LTE) Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria

Role: lead

NCT05774184Phase 2Completed

A Study of CDX-0159 in Patients With Eosinophilic Esophagitis

Role: lead

NCT02839265Phase 2Completed

FLT3 Ligand Immunotherapy and Stereotactic Radiotherapy for Advanced Non-small Cell Lung Cancer

Role: collaborator

NCT05349890Phase 1Active Not Recruiting

Personalized TCR-T: Study of Adoptively Transferred T-cell Receptor Gene-engineered T Cells (TCR-T)

Role: collaborator

NCT07330778Phase 1Recruiting

A Study of CDX-622 in Participants With Mild to Moderate Asthma

Role: lead

NCT07266402Phase 3Recruiting

A Study to Investigate Efficacy, Safety and Tolerability of Barzolvolimab Versus Placebo in Adults With Cold Induced Urticaria and Symptomatic Dermographism Inadequately Controlled by H1-antihistamines (EMBARQ - ColdU and SD)

Role: lead

NCT04930783Phase 1Active Not Recruiting

NeoVax + CDX-301 and Nivolumab or Pembrolizumab in Melanoma

Role: collaborator

NCT06445023Phase 3Active Not Recruiting

A Phase 3 Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria

Role: lead

NCT06455202Phase 3Active Not Recruiting

A Phase 3 Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria (CSU)

Role: lead

NCT05231122Phase 2Recruiting

Pembrolizumab Combined With Bevacizumab With or Without Agonist Anti-CD40 CDX-1140 for the Treatment of Patients With Recurrent Ovarian Cancer

Role: collaborator

NCT03358719Phase 1Completed

DEC-205/NY-ESO-1 Fusion Protein CDX-1401, Poly ICLC, Decitabine, and Nivolumab in Treating Patients With Myelodysplastic Syndrome or Acute Myeloid Leukemia

Role: collaborator

NCT06366750Phase 2Active Not Recruiting

A Study of Barzolvolimab in Patients With Prurigo Nodularis

Role: lead

NCT03804944Phase 2Recruiting

Converting HR+ Breast Cancer Into an Individualized Vaccine

Role: collaborator

NCT05405660Phase 2Completed

A Study of CDX-0159 in Patients With Chronic Inducible Urticaria

Role: lead

NCT05029999Phase 1Recruiting

CD40 Agonist, Flt3 Ligand, and Chemotherapy in HER2 Negative Breast Cancer

Role: collaborator

NCT05788484Phase 1Completed

A Study of CDX-585 in Patients With Advanced Malignancies

Role: lead

NCT03688178Phase 2Active Not Recruiting

DC Migration Study to Evaluate TReg Depletion In GBM Patients With and Without Varlilumab

Role: collaborator

NCT05368285Phase 2Completed

A Phase 2 Study of CDX-0159 in Patients With Chronic Spontaneous Urticaria

Role: lead