Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 80/100

Failure Rate

36.8%

7 terminated/withdrawn out of 19 trials

Success Rate

46.2%

-40.3% vs industry average

Late-Stage Pipeline

0%

0 trials in Phase 3/4

Results Transparency

167%

10 of 6 completed trials have results

Key Signals

5 recruiting10 with results7 terminated

Enrollment Performance

Analytics

Phase 1
12(63.2%)
Phase 2
6(31.6%)
Early Phase 1
1(5.3%)
19Total
Phase 1(12)
Phase 2(6)
Early Phase 1(1)

Activity Timeline

Global Presence

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Clinical Trials (19)

Showing 19 of 19 trials
NCT03435952Phase 1Active Not Recruiting

Pembrolizumab With Intratumoral Injection of Clostridium Novyi-NT

Role: collaborator

NCT05985954Phase 1Recruiting

Open-label Phase 1b Study of Ulixertinib and Cetuximab or Ulixertinib in Combination With Cetuximab and Encorafenib in Patients With Unresectable or Metastatic Colorectal Cancer Who Have Previously Received EGFR or BRAF-directed Therapy

Role: collaborator

NCT05804227Early Phase 1Recruiting

Window-of-Opportunity Trial of Ulixertinib for MAPK-Activated Gliomas

Role: collaborator

NCT03417739Phase 2Terminated

A Phase II Study of BVD-523 in Metastatic Uveal Melanoma

Role: collaborator

NCT06411821Phase 2Recruiting

Ulixertinib in People With Histiocytic Neoplasms

Role: collaborator

NCT06773195Phase 1Recruiting

A Study of Ruxolitinib in Combination With Ulixertinib in People With Myelofibrosis

Role: collaborator

NCT05221320Phase 2Terminated

Trial of Ulixertinib in Combination With Hydroxychloroquine in Patients With Advanced Gastrointestinal (GI) Malignancies

Role: lead

NCT03454035Phase 1Recruiting

Ulixertinib/Palbociclib in Patients With Advanced Pancreatic and Other Solid Tumors

Role: collaborator

NCT04145297Phase 1Completed

Ulixertinib (BVD-523) and Hydroxychloroquine in Patients W Advanced MAPK-Mutated Gastrointestinal Adenocarcinomas

Role: collaborator

NCT04488003Phase 2Terminated

Study of Ulixertinib for Patients With Advanced Malignancies Harboring MEK or Atypical BRAF Alterations

Role: lead

NCT02608229Phase 1Terminated

BVD-523 Plus Nab-paclitaxel and Gemcitabine in Patients With Metastatic Pancreatic Cancer

Role: collaborator

NCT01781429Phase 1Completed

Phase I Dose-Escalation, Safety, Pharmacokinetic and Pharmacodynamic Study of BVD-523 in Patients With Advanced Malignancies

Role: lead

NCT01924689Phase 1Completed

Safety Study of Intratumoral Injection of Clostridium Novyi-NT Spores to Treat Patients With Solid Tumors That Have Not Responded to Standard Therapies

Role: lead

NCT02994732Phase 1Completed

Absorption, Metabolism and Excretion (AME) of Single Dose Radiolabeled BVD-523 in Volunteers

Role: lead

NCT02296242Phase 1Completed

Phase 1/2 Study of the ERK1/2 Inhibitor BVD-523 in Patients With Acute Myelogenous Leukemia or Myelodysplastic Syndromes

Role: lead

NCT01764919Phase 2Terminated

[124I]FIAU PET-CT Scanning in Diagnosing Osteomyelitis in Patients With Diabetic Foot Infection

Role: lead

NCT01705496Phase 2Terminated

[124I]FIAU PET-CT Scanning in Patients With Pain in a Prosthetic Knee or Hip Joint

Role: lead

NCT01118819Phase 1Terminated

Safety Study of Clostridium Novyi-NT Spores to Treat Patients With Solid Tumors That Have Not Responded to Standard Therapies

Role: lead

NCT01337466Phase 1Completed

Biodistribution and Dosimetry Evaluation of [124I]FIAU

Role: lead

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