Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Moderate Risk

Score: 45/100

Failure Rate

0.0%

0 terminated/withdrawn out of 21 trials

Success Rate

100.0%

+13.5% vs industry average

Late-Stage Pipeline

10%

2 trials in Phase 3/4

Results Transparency

38%

5 of 13 completed trials have results

Key Signals

5 with results

Enrollment Performance

Analytics

Phase 1
19(90.5%)
Phase 3
2(9.5%)
21Total
Phase 1(19)
Phase 3(2)

Activity Timeline

Global Presence

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Clinical Trials (21)

Showing 20 of 21 trials
NCT06125522Phase 1Active Not Recruiting

TACTIVE-U: A Study to Learn About the Study Medicine (Vepdegestrant) When Given With Other Medicines in People With Advanced or Metastatic Breast Cancer. (Sub-Study C)

Role: collaborator

NCT04072952Phase 1Completed

A Phase 1/2 Trial of ARV-471 Alone and in Combination With Palbociclib (IBRANCE®) in Patients With ER+/HER2- Locally Advanced or Metastatic Breast Cancer

Role: lead

NCT05654623Phase 3Active Not Recruiting

A Study to Learn About a New Medicine Called Vepdegestrant (ARV-471, PF-07850327) in People Who Have Advanced Metastatic Breast Cancer

Role: collaborator

NCT05573555Phase 1Active Not Recruiting

TACTIVE-U: A Study to Learn About the Study Medicine (Vepdegestrant) When Given With Other Medicines in People With Advanced or Metastatic Breast Cancer (Sub-Study B)

Role: collaborator

NCT06206837Phase 1Active Not Recruiting

A Study to Learn About Vepdegestrant When Given With PF-07220060 to People With Advanced or Metastatic Breast Cancer.

Role: collaborator

NCT05548127Phase 1Active Not Recruiting

TACTIVE-U: A Study to Learn About the Study Medicine (Vepdegestrant) When Given With Other Medicines in People With Advanced or Metastatic Breast Cancer (Sub-Study A)

Role: collaborator

NCT05909397Phase 3Active Not Recruiting

Vepdegestrant (ARV-471/PF-07850327) + Palbociclib vs Letrozole + Palbociclib in ER(+)/HER2(-) Advanced Breast Cancer

Role: collaborator

NCT07231991Phase 1Not Yet Recruiting

A Study to Learn How the Body Processes the Study Medicine Called Vepdegestrant in People With Loss of Liver Function

Role: collaborator

NCT05501769Phase 1Completed

ARV-471 in Combination With Everolimus for the Treatment of Advanced or Metastatic ER+, HER2- Breast Cancer

Role: lead

NCT06911788Phase 1Completed

A Study to Learn How a Tablet Compared With an IV Infusion of the Study Medicine Called Vepdegestrant is Taken up Into the Blood in Healthy Adults

Role: collaborator

NCT06645938Phase 1Completed

A Study to Learn How Different Tablets of the Study Medicine Vepdegestrant Are Taken up Into the Blood in Healthy Adults

Role: collaborator

NCT05732428Phase 1Completed

A Study to Learn About the Study Medicine Called Vepdegestrant (ARV-471, PF-07850327) in People With ER+/HER2- Advanced Breast Cancer in China

Role: collaborator

NCT06256510Phase 1Completed

A Study to Learn If the Study Medicine Called Vepdegestrant Changes How the Body Processes the Other Study Medicine Called Midazolam

Role: collaborator

NCT05463952Phase 1Active Not Recruiting

A Study to Learn About the Vepdegestrant (ARV-471, PF-07850327) in People With ER+/HER2- Locally Advanced or Metastatic Breast Cancer (BC)

Role: collaborator

NCT06347861Phase 1Completed

A Study to Learn How Various Tablets of the Study Medicine Vepdegestrant Are Taken up Into the Blood of Healthy Adults

Role: collaborator

NCT05538312Phase 1Completed

A Study to Understand the Effect of Itraconazole on the Levels of a Study Medicine Called ARV-471 in Healthy Adults

Role: collaborator

NCT05673889Phase 1Completed

A Study to Understand the Effect of a Study Medicine Called ARV-471 on Dabigatran Etexilate in Healthy Adults

Role: collaborator

NCT05652660Phase 1Completed

A Study to Understand the Effect of a Study Medicine Called ARV-471 on Rosuvastatin in Healthy Adults

Role: collaborator

NCT06275841Phase 1Completed

A Study to Learn If the Study Medicine Esomeprazole Changes How the Body Processes the Other Study Medicine Vepdegestrant

Role: collaborator

NCT06005688Phase 1Completed

A Study to Understand the Effects of Carbamazepine on How Vepdegestrant is Processed in Healthy Participants

Role: collaborator