Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 75/100

Failure Rate

20.0%

7 terminated/withdrawn out of 35 trials

Success Rate

78.1%

-8.4% vs industry average

Late-Stage Pipeline

11%

4 trials in Phase 3/4

Results Transparency

48%

12 of 25 completed trials have results

Key Signals

12 with results6 terminated

Enrollment Performance

Analytics

Phase 2
15(48.4%)
Phase 1
12(38.7%)
Phase 3
4(12.9%)
31Total
Phase 2(15)
Phase 1(12)
Phase 3(4)

Activity Timeline

Global Presence

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Clinical Trials (35)

Showing 20 of 35 trials
NCT01570868Phase 2Terminated

Ponatinib - Frontline for Chronic Myeloid Leukemia (CML) in Accelerated Phase (AP)

Role: collaborator

NCT03535740Phase 2Completed

A Study of Brigatinib in Participants With Anaplastic Lymphoma Kinase-Positive (ALK+), Advanced Non-Small-Cell Lung Cancer (NSCLC) Progressed on Alectinib or Ceritinib

Role: lead

NCT02455024Terminated

An Observational Registry to Evaluate the Incidence of and Risk Factors for Vascular Occlusive Events Associated With ICLUSIG®

Role: lead

NCT00770185Phase 2Completed

Ridaforolimus in Treating Patients With Recurrent Metastatic and/or Locally Advanced Endometrial Cancer

Role: collaborator

NCT01667133Phase 1Completed

A Study of Ponatinib in Japanese Participants With Chronic Myeloid Leukemia (CML) and Ph+ Acute Lymphoblastic Leukemia (ALL)

Role: lead

NCT01935336Phase 2Completed

Study of Ponatinib in Patients With Lung Cancer Preselected Using Different Candidate Predictive Biomarkers

Role: collaborator

NCT02627677Phase 3Terminated

A Study Comparing Ponatinib and Nilotinib in Participants With Chronic Myeloid Leukemia

Role: lead

NCT02737501Phase 3Completed

ALTA-1L Study: A Study of Brigatinib Versus Crizotinib in Anaplastic Lymphoma Kinase Positive (ALK+) Advanced Non-small Cell Lung Cancer (NSCLC) Participants

Role: lead

NCT01449461Phase 1Completed

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Anti-Tumor Activity of the Oral Anaplastic Lymphoma Kinase (ALK)/Epidermal Growth Factor Receptor (EGFR) Inhibitor Brigatinib (AP26113)

Role: lead

NCT02094573Phase 2Completed

A Study to Evaluate the Efficacy of Brigatinib (AP26113) in Participants With Anaplastic Lymphoma Kinase (ALK)-Positive, Non-small Cell Lung Cancer (NSCLC) Previously Treated With Crizotinib

Role: lead

NCT01207440Phase 2Completed

Ponatinib for Chronic Myeloid Leukemia (CML) Evaluation and Ph+ Acute Lymphoblastic Leukemia (ALL)

Role: lead

NCT00836927Phase 2Terminated

Extension Trial of Deforolimus (Ridaforolimus, MK-8669) in Participants With Advanced Cancer (MK-8669-038)

Role: collaborator

NCT01874665Phase 2Completed

A Phase 2 Trial of Ponatinib in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumor

Role: lead

NCT00660920Phase 1Completed

Safety Study of AP24534 to Treat Chronic Myelogenous Leukemia (CML) and Other Hematological Malignancies

Role: lead

NCT02784158Unknown

An Expanded Access Study of Brigatinib for Patients With ALK-positive Advanced Non-Small Cell Lung Cancer

Role: lead

NCT01592136Unknown

Expanded Access Program of Ponatinib

Role: lead

NCT02829840Phase 1Withdrawn

Dose-Escalation Study of Ponatinib, a FLT3 Inhibitor, With and Without Combination of 5-Azacytidine, in Patients With FLT3-Mutated Acute Myeloid Leukemia (AML)

Role: collaborator

NCT00110188Phase 2Completed

Ridaforolimus (AP23573/MK-8669) in Participants With Taxane-Resistant Androgen-Independent Prostate Cancer (AIPC)(MK-8669-017)

Role: collaborator

NCT00060632Phase 1Completed

Safety Study of Ridaforolimus in Patients With Advanced, Refractory or Recurrent Malignancies (MK-8669-001 AM5)(COMPLETED)

Role: collaborator

NCT00060645Phase 1Completed

Safety Study of AP23573 in Patients With Advanced, Refractory or Recurrent Malignancies (8669-013)(COMPLETED)

Role: collaborator