Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 60/100

Failure Rate

7.1%

4 terminated/withdrawn out of 56 trials

Success Rate

85.2%

-1.4% vs industry average

Late-Stage Pipeline

9%

5 trials in Phase 3/4

Results Transparency

4%

1 of 23 completed trials have results

Key Signals

12 recruiting1 with results

Enrollment Performance

Analytics

Phase 1
33(58.9%)
Phase 2
17(30.4%)
Phase 3
5(8.9%)
Early Phase 1
1(1.8%)
56Total
Phase 1(33)
Phase 2(17)
Phase 3(5)
Early Phase 1(1)

Activity Timeline

Global Presence

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Clinical Trials (56)

Showing 20 of 56 trials
NCT07667335Phase 1Recruiting

Enfortumab Vedotin, Pembrolizumab and Quemliclustat for the Treatment of Unresectable Locally Advanced and Metastatic Urothelial Cancer

Role: collaborator

NCT05891171Phase 1Active Not Recruiting

Study of AB598 Monotherapy and Combination Therapy in Participants With Advanced Cancers

Role: lead

NCT05329766Phase 2Active Not Recruiting

A Safety and Efficacy Study of Treatment Combinations With and Without Chemotherapy in Adult Participants With Advanced Upper Gastrointestinal Tract Malignancies

Role: lead

NCT07011719Phase 3Recruiting

Study of Casdatifan and Cabozantinib Versus Placebo and Cabozantinib in Patients With Advanced Clear Cell Renal Cell Carcinoma

Role: lead

NCT06608927Phase 3Active Not Recruiting

Study of Quemliclustat and Chemotherapy Versus Placebo and Chemotherapy in Patients With Metastatic Pancreatic Ductal Adenocarcinoma

Role: lead

NCT07748988Phase 1Recruiting

Casdatifan for the Treatment of Refractory Metastatic Clear Cell Renal Cell Carcinoma

Role: collaborator

NCT04104672Phase 1Completed

A Study to Evaluate the Safety and Tolerability of AB680 in Participants With Gastrointestinal Malignancies

Role: lead

NCT07751250Phase 1Recruiting

Comparative PK Assessment Study of Casdatifan in Moderate Hepatically Impaired Participants Versus Matched Participants With Normal Hepatic Function

Role: lead

NCT05568095Phase 3Completed

A Clinical Trial of a New Combination Treatment, Domvanalimab and Zimberelimab, Plus Chemotherapy, for People With an Upper Gastrointestinal Tract Cancer That Cannot be Removed With Surgery That Has Spread to Other Parts of the Body

Role: lead

NCT06727565Phase 2Active Not Recruiting

Study of Novel Treatment Combination Therapies in Participants With Head and Neck Squamous Cell Carcinoma Regardless of PD-L1 Expression Status; Substudy-01

Role: collaborator

NCT04736173Phase 2Active Not Recruiting

Study Evaluating Effectiveness and Safety of Zimberelimab and Domvanalimab in Lung Cancer

Role: lead

NCT05536141Phase 1Recruiting

A Phase 1 Study of AB521 Monotherapy and Combination Therapies in Renal Cell Carcinoma and Other Solid Tumors

Role: lead

NCT05211895Phase 3Active Not Recruiting

A Global Study to Assess the Effects of Durvalumab + Domvanalimab Following Concurrent Chemoradiation in Participants With Stage III Unresectable NSCLC

Role: collaborator

NCT07662057Phase 1Recruiting

A Study to Investigate the Safety, Tolerability, and PK of AB102 in Healthy Participants

Role: lead

NCT06048133Phase 2Active Not Recruiting

Study of Gemcitabine, Cisplatin, AB680 and AB122 During First Line Treatment of Advanced Biliary Tract Cancers (QUIC)

Role: collaborator

NCT07641881Phase 1Completed

A Bioequivalence Study Between Two Casdatifan Tablet Strengths and Food Effect Study of Casdatifan in Healthy Adult Participants

Role: lead

NCT06120075Phase 1Active Not Recruiting

A Study of AB801 Monotherapy and Combination Therapy in Participants With Advanced Malignancies

Role: lead

NCT07000149Phase 1Active Not Recruiting

A Study to Investigate the Efficacy and Safety of Volrustomig ± Casdatifan vs Nivolumab + Ipilimumab as 1L Treatment for Advanced ccRCC

Role: collaborator

NCT05024097Phase 2Recruiting

A Phase I-II Study to Test the Safety and Efficacy of PD1 (AB122) and Adenosine Receptor (AB928) Antagonists With Chemotherapy After Short-Course Radiation for Rectal Cancer.

Role: collaborator

NCT05724563Phase 2Active Not Recruiting

Domvanalimab and Zimberelimab in Advanced Liver Cancers

Role: collaborator