Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 65/100

Failure Rate

20.0%

3 terminated/withdrawn out of 15 trials

Success Rate

75.0%

-11.5% vs industry average

Late-Stage Pipeline

7%

1 trials in Phase 3/4

Results Transparency

56%

5 of 9 completed trials have results

Key Signals

2 recruiting5 with results

Enrollment Performance

Analytics

Phase 2
7(46.7%)
Phase 1
7(46.7%)
Phase 3
1(6.7%)
15Total
Phase 2(7)
Phase 1(7)
Phase 3(1)

Activity Timeline

Global Presence

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Clinical Trials (15)

Showing 15 of 15 trials
NCT07390968Phase 2Not Yet Recruiting

Self-Amplifying mRNA COVID-19 Vaccine (LUNAR-COV19) Versus Comirnaty Vaccine in Adult Hematopoietic Cell Transplant Patients

Role: collaborator

NCT06602531Phase 1Completed

Safety and Immunogenicity Study of Self-Amplifying RNA Pandemic Influenza Vaccine in Adults

Role: lead

NCT06279871Phase 3Completed

Immunogenicity and Safety Study of Self-amplifying mRNA COVID-19 Vaccine Administered With Influenza Vaccines in Adults

Role: lead

NCT05012943Phase 2Completed

The ARCT-154 Self-Amplifying RNA Vaccine Efficacy Study (ARCT-154-01)

Role: collaborator

NCT05037097Phase 1Completed

A Trial Evaluating the Safety and Immunogenicity of 3 COVID-19 SARS-CoV-2 RNA Vaccines in Healthy Adults

Role: lead

NCT06747858Phase 2Recruiting

Safety, Tolerability and Efficacy Study of ARCT-032 in People With Cystic Fibrosis

Role: lead

NCT06125691Phase 1Completed

Safety and Immunogenicity First-in-human Dose-ranging Study of Self-Amplifying RNA Seasonal Influenza Vaccine in Adults

Role: lead

NCT05526066Phase 2Terminated

Study for Adolescents and Adults With Ornithine Transcarbamylase Deficiency to Evaluate Safety and Tolerability of ARCT-810

Role: lead

NCT04668339Phase 2Terminated

A Trial Evaluating the Safety and Effects of an RNA Vaccine ARCT-021 in Healthy Adults

Role: lead

NCT06488313Phase 2Recruiting

A Study to Evaluate the Pharmacodynamics and Safety of ARCT-810 in Participants With OTCD

Role: lead

NCT04728347Phase 2Terminated

Open Label Extension Study to Assess the Safety and Long-Term Immunogenicity of ARCT-021

Role: lead

NCT05712538Phase 1Completed

Safety, Tolerability, and Pharmacokinetics of ARCT-032 in Healthy Adult Subjects and Adults With Cystic Fibrosis.

Role: lead

NCT04442347Phase 1Completed

Phase 1b Study to Assess Safety, Tolerability, and Pharmacokinetics of ARCT-810 in Stable Adult Subjects With Ornithine Transcarbamylase Deficiency

Role: lead

NCT04416126Phase 1Completed

Safety, Tolerability and Pharmacokinetics of ARCT-810 in Healthy Adult Subjects

Role: lead

NCT04480957Phase 1Completed

Ascending Dose Study of Investigational SARS-CoV-2 Vaccine ARCT-021 in Healthy Adult Subjects

Role: lead

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