Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 70/100

Failure Rate

27.3%

3 terminated/withdrawn out of 11 trials

Success Rate

66.7%

-19.8% vs industry average

Late-Stage Pipeline

0%

0 trials in Phase 3/4

Results Transparency

100%

6 of 6 completed trials have results

Key Signals

6 with results

Enrollment Performance

Analytics

Phase 1
7(63.6%)
Phase 2
4(36.4%)
11Total
Phase 1(7)
Phase 2(4)

Activity Timeline

Global Presence

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Clinical Trials (11)

Showing 11 of 11 trials
NCT04130854Phase 2Completed

INNATE: Immunotherapy During Neoadjuvant Therapy for Rectal Cancer

Role: collaborator

NCT02706353Phase 1Terminated

APX005M in Combination With Systemic Pembrolizumab in Patients With Metastatic Melanoma

Role: collaborator

NCT04495257Phase 1Active Not Recruiting

A Study of APX005M in Combination With Nivolumab and Ipilimumab in Treatment Naïve Patients With Advanced Melanoma or Renal Cell Carcinoma (RCC)

Role: collaborator

NCT03719430Phase 2Active Not Recruiting

APX005M and Doxorubicin in Advanced Sarcoma

Role: collaborator

NCT03502330Phase 1Completed

APX005M With Nivolumab and Cabiralizumab in Advanced Melanoma, Non-small Cell Lung Cancer or Renal Cell Carcinoma

Role: collaborator

NCT03165994Phase 2Completed

APX005M With Concurrent Chemoradiation for Resectable Esophageal and Gastroesophageal Junction Cancers

Role: lead

NCT04337931Phase 2Terminated

A Study to Evaluate Sotigalimab (APX005M) in Subjects With Unresectable or Metastatic Melanoma

Role: lead

NCT03123783Phase 1Completed

CD40 Agonistic Antibody APX005M (Sotigalimab) in Combination With Nivolumab

Role: lead

NCT02482168Phase 1Completed

Study of the CD40 Agonistic Monoclonal Antibody APX005M

Role: lead

NCT03214250Phase 1Completed

Safety and Efficacy of APX005M With Gemcitabine and Nab-Paclitaxel With or Without Nivolumab in Patients With Previously Untreated Metastatic Pancreatic Adenocarcinoma

Role: collaborator

NCT03597282Phase 1Terminated

A Personal Cancer Vaccine (NEO-PV-01) and APX005M or Ipilimumab With Nivolumab in Patients With Advanced Melanoma

Role: collaborator

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