Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Moderate Risk

Score: 45/100

Failure Rate

6.5%

3 terminated/withdrawn out of 46 trials

Success Rate

92.1%

+5.6% vs industry average

Late-Stage Pipeline

4%

2 trials in Phase 3/4

Results Transparency

46%

16 of 35 completed trials have results

Key Signals

4 recruiting16 with results

Enrollment Performance

Analytics

Phase 2
13(43.3%)
N/A
11(36.7%)
Phase 1
3(10.0%)
Phase 3
1(3.3%)
Phase 4
1(3.3%)
Early Phase 1
1(3.3%)
30Total
Phase 2(13)
N/A(11)
Phase 1(3)
Phase 3(1)
+2 more

Activity Timeline

Global Presence

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Clinical Trials (46)

Showing 20 of 46 trials
NCT05377424Phase 1Active Not Recruiting

Adenosine 2A Receptor Antagonism and AIH in ALS

Role: collaborator

NCT00136500Recruiting

Clinical Research in ALS Study

Role: collaborator

NCT00317616Recruiting

The Pre-symptomatic Familial Amyotrophic Lateral Sclerosis (Pre-fALS) Study

Role: collaborator

NCT04220021Phase 2Active Not Recruiting

Safety and Therapeutic Potential of the FDA-approved Drug Metformin for C9orf72 ALS/FTD

Role: collaborator

NCT06527222Phase 2Recruiting

A Study of Ranolazine in ALS

Role: collaborator

NCT02327845Enrolling By Invitation

Phenotype, Genotype & Biomarkers in ALS and Related Disorders

Role: collaborator

NCT06771414Not Yet Recruiting

Metagenomic Characterization of the Intestinal Microbiota in ALS Patients and Association With Clinical Phenotypes

Role: collaborator

NCT04490148Not ApplicableCompleted

Remote Pulmonary Function Testing and Nurse Coaching in ALS

Role: collaborator

NCT06418646Recruiting

Patients' and Caregivers' Views of Multidimensional Care in Amyotropic Lateral Sclerosis in Germany

Role: collaborator

NCT03127514Phase 2Completed

AMX0035 in Patients With Amyotrophic Lateral Sclerosis (ALS)

Role: collaborator

NCT03456882Phase 2Completed

The Effect of RNS60 on ALS Biomarkers

Role: collaborator

NCT01938495Phase 2Completed

Diaphragm Pacing System (DPS) In Participants With Amyotrophic Lateral Sclerosis (ALS)

Role: collaborator

NCT03883581Phase 1Completed

Impact of Nuedexta on Bulbar Physiology and Function in ALS

Role: collaborator

NCT02795897Completed

Genomic Translation for Amyotrophic Lateral Sclerosis Care

Role: collaborator

NCT04051333Completed

The E-health Application To Modify ORal Energy Intake and Measure Outcomes REmotely in ALS Clinical Trial (EAT MORE2)

Role: collaborator

NCT02819765Completed

Deep Phenotyping in Patients With ALS

Role: collaborator

NCT04947436Not ApplicableCompleted

ALS and Airway Clearance (ALSAC) Therapy

Role: collaborator

NCT02686268Completed

Understanding Clinical Phenotype and Collecting Biomarker Samples in C9ORF72 ALS

Role: collaborator

NCT03519880Not ApplicableTerminated

A Pilot Study of the Utility of 3D Printed Masks for ALS Subjects

Role: collaborator

NCT01363882Not ApplicableTerminated

Polysomnography-directed Noninvasive Ventilation in Amyotrophic Lateral Sclerosis (ALS)

Role: collaborator