Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 65/100

Failure Rate

16.7%

2 terminated/withdrawn out of 12 trials

Success Rate

83.3%

-3.2% vs industry average

Late-Stage Pipeline

17%

2 trials in Phase 3/4

Results Transparency

20%

2 of 10 completed trials have results

Key Signals

2 with results

Enrollment Performance

Analytics

Phase 2
6(50.0%)
Phase 1
3(25.0%)
Phase 3
2(16.7%)
N/A
1(8.3%)
12Total
Phase 2(6)
Phase 1(3)
Phase 3(2)
N/A(1)

Activity Timeline

Global Presence

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Clinical Trials (12)

Showing 12 of 12 trials
NCT04987294Phase 2Terminated

Phase IIa Study of ALLN-346 (Engineered Urate Oxidase) in Subjects With Hyperuricemia, Gout and Chronic Kidney Disease

Role: lead

NCT04987242Phase 2Completed

An Inpatient Study of ALLN-346 (Engineered Urate Oxidase) in Hyperuricemic Subjects (Study 201)

Role: lead

NCT05168683Phase 1Completed

Scintigraphy Study in Healthy Volunteers to Characterize the Performance of ALLN-346 Tablets

Role: lead

NCT03847090Phase 3Terminated

Establishing the Safety and Efficacy of Reloxaliase in Patients With Enteric Hyperoxaluria

Role: lead

NCT03095885Not ApplicableCompleted

A Pilot Study of Oxalate Absorption in Secondary Hyperoxaluria

Role: lead

NCT04236219Phase 1Completed

ALLN-346 Single Ascending Dose (SAD) Study in Healthy Volunteers

Role: lead

NCT04829435Phase 1Completed

Study 102: Multiple Ascending Dose Study of ALLN-346 (Engineered Urate Oxidase)

Role: lead

NCT03391804Phase 2Completed

Study of ALLN-177 in Patients Aged 12 Years or Older With Enteric or Primary Hyperoxaluria and Hyperoxalemia

Role: lead

NCT03456830Phase 3Completed

Evaluate ALLN-177 in Patients With Enteric Hyperoxaluria

Role: lead

NCT02289755Phase 2Completed

Evaluating ALLN-177 for Reducing Urinary Oxalate Excretion in Calcium Oxalate Kidney Stone Formers With Hyperoxaluria

Role: lead

NCT02503345Phase 2Completed

Evaluate the Effect of ALLN-177 in Reducing Urinary Oxalate in Patients With Hyperoxaluria and Kidney Stones

Role: lead

NCT02547805Phase 2Completed

Evaluate the Effect of ALLN-177 in Reducing Urinary Oxalate in Patients With Secondary Hyperoxaluria and Kidney Stones Over 28 Days

Role: lead

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