Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 60/100

Failure Rate

12.5%

2 terminated/withdrawn out of 16 trials

Success Rate

71.4%

-15.1% vs industry average

Late-Stage Pipeline

6%

1 trials in Phase 3/4

Results Transparency

0%

0 of 5 completed trials have results

Key Signals

3 recruiting

Enrollment Performance

Analytics

Phase 2
8(50.0%)
Phase 1
6(37.5%)
N/A
1(6.3%)
Phase 3
1(6.3%)
16Total
Phase 2(8)
Phase 1(6)
N/A(1)
Phase 3(1)

Activity Timeline

Global Presence

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Clinical Trials (16)

Showing 16 of 16 trials
NCT06232083Phase 1Recruiting

A Multi Tumor, Open Phase I Clinical Study on the Progression of First-line Anti-tumor Therapy Using Cardonizumab Combined With Pulsed Low-dose Rate External Irradiation (PLDR)

Role: collaborator

NCT06940921Phase 1Active Not Recruiting

SBRT-LDRT-Cadonilimab for Advanced Gastric, Colorectal and Ovarian Cancers With Peritoneal Metastases

Role: collaborator

NCT05587374Phase 3Active Not Recruiting

Cadonilimab (PD-1/CTLA-4 Bispecific Blockade) and Chemoradiotherapy in Nasopharyngeal Carcinoma (GEMSTONE)

Role: collaborator

NCT06714084Not ApplicableEnrolling By Invitation

CNCMT:a Multi-center, Prospective, Single-arm Study

Role: collaborator

NCT04220307Phase 2Completed

A Study of a PD-1/CTLA-4 Bispecific Antibody AK104 in Patients With Metastatic Nasopharyngeal Carcinoma

Role: collaborator

NCT03852251Phase 1Completed

A Study of AK104, a PD-1/CTLA-4 Bispecific Antibody, for Advanced Solid Tumors or With mXELOX/XELOX as First-line Therapy for Advanced Gastric or GEJ Adenocarcinoma

Role: collaborator

NCT06426797Phase 2Not Yet Recruiting

Neoadjuvant Cadonilimab Combined With Anlotinib in Locally Advanced Resectable Esophageal Squamous Cell Carcinoma

Role: collaborator

NCT04444167Phase 1Completed

A Study of Anti-PD-1/CTLA-4 Bispecific AK104 Plus Lenvatinib in First-line Advanced Hepatocellular Carcinoma

Role: collaborator

NCT04728321Phase 2Completed

A Study of Anti-PD-1/CTLA-4 Bispecific AK104 Alone or in Combination With Lenvatinib in Advanced Hepatocellular Carcinoma

Role: collaborator

NCT06277674Phase 2Recruiting

Efficacy of Cadonilimab in Non-squamous Non-small Cell Lung Cancer Patients Resistant to EGFR-TKI

Role: collaborator

NCT06001151Phase 2Recruiting

Cadonilimab (AK104) Plus Chemotherapy as First-line Treatment in Non-squamous Non-Small Cell Lung Cancer (NSCLC) Patients With Programmed Cell Death Ligand 1 (PD-L1) Negative

Role: collaborator

NCT05947201Phase 2Unknown

Neoadjuvant Treatment of Cadonilimab Combined Albumin-paclitaxel, Cisplatin and Fluorouracil for Resectable Locally Advanced Esophageal Squamous Cell Carcinoma

Role: collaborator

NCT04444141Phase 1Terminated

A Study of PD-1/CTLA-4 Bispecific AK104 in Relapsed or Refractory Peripheral T-cell Lymphoma

Role: collaborator

NCT04547101Phase 2Terminated

A Study of AK104 in Subjects With Locally Advanced Unresectable or Metastatic MSI-H/dMMR Solid Tumors

Role: collaborator

NCT04172454Phase 1Completed

Safety and Efficacy of AK104, a PD-1/CTLA-4 Bispecific Antibody, in Selected Advanced Solid Tumors

Role: collaborator

NCT05522894Phase 2Unknown

AK104 Alone or in Combination With Chemotherapy in the First-line Treatment of ESCC

Role: collaborator

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