Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 80/100

Failure Rate

27.8%

5 terminated/withdrawn out of 18 trials

Success Rate

58.3%

-28.2% vs industry average

Late-Stage Pipeline

0%

0 trials in Phase 3/4

Results Transparency

114%

8 of 7 completed trials have results

Key Signals

4 recruiting8 with results

Enrollment Performance

Analytics

Phase 1
9(52.9%)
Phase 2
8(47.1%)
17Total
Phase 1(9)
Phase 2(8)

Activity Timeline

Global Presence

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Clinical Trials (18)

Showing 18 of 18 trials
NCT06494150Phase 2Recruiting

Nab-Sirolimus and Endocrine Therapy in Recurrent Low Grade Serous Ovarian Cancer (NARETO)

Role: collaborator

NCT05661461Phase 1Recruiting

Dose-escalation Study to Assess Safety and Pharmacokinetics of Nab-Sirolimus in Patients With Locally Advanced or Metastatic Solid Tumors and Moderate Liver Impairment

Role: lead

NCT05997017Phase 2Recruiting

Trial of Nab-Sirolimus in Combination With Letrozole in Patients With Advanced or Recurrent Endometrioid Endometrial Cancer

Role: lead

NCT03660930Phase 1Terminated

Nab-Sirolimus and Pazopanib Hydrochloride in Treating Patients With Advanced Nonadipocytic Soft Tissue Sarcomas

Role: collaborator

NCT05840510Phase 1Terminated

Adagrasib in Combination With Nab-Sirolimus in Patients With Advanced Solid Tumors and Non-Small Cell Lung Cancer With a KRAS G12C Mutation (KRYSTAL -19)

Role: collaborator

NCT03190174Phase 1Completed

Nivolumab (Opdivo®) Plus ABI-009 (Nab-rapamycin) for Advanced Sarcoma and Certain Cancers

Role: collaborator

NCT02587325Phase 1Completed

Phase 1/1b Study With Nab-sirolimus for Patients With Severe Pulmonary Arterial Hypertension

Role: lead

NCT05997056Phase 2Recruiting

Trial of Nab-sirolimus in Patients With Well-differentiated Neuroendocrine Tumors (NETs) of the Gastrointestinal Tract, Lung, or Pancreas Who Have Not Received Prior Treatment With mTOR Inhibitors

Role: lead

NCT05103358Phase 2Active Not Recruiting

Phase 2 Basket Trial of Nab-sirolimus in Patients With Malignant Solid Tumors With Pathogenic Alterations in TSC1/TSC2 Genes (PRECISION 1)

Role: lead

NCT03439462Phase 1Completed

Nab-Sirolimus in Combination With FOLFOX & BEV as 1st Line Therapy in Patients With Advanced or Metastatic Colorectal Cancer

Role: lead

NCT03463265Phase 2Completed

Nab-sirolimus in Recurrent High Grade Glioma and Newly Diagnosed Glioblastoma

Role: lead

NCT03646240Phase 1Completed

ABI-009 (Nab-rapamycin) for Surgically-Refractory Epilepsy (RaSuRE)

Role: collaborator

NCT02494570Phase 2Completed

A Phase 2 Study of Nab-sirolimus (ABI-009) in Patients With Advanced Malignant PEComa

Role: lead

NCT03817515Unknown

Expanded Access for ABI-009 in Patients With Advanced PEComa and Patients With a Malignancy With Relevant Genetic Mutations or mTOR Pathway Activation

Role: lead

NCT03747328Phase 2Withdrawn

ABI-009 (Nab-sirolimus) in Patients With Genetically-confirmed Leigh or Leigh-like Syndrome

Role: lead

NCT03670030Phase 2Terminated

A Study to testABI-009 in Patients With Metastatic, Unresectable, Low or Intermediate Grade Neuroendocrine Tumors of the Lung or Gastroenteropancreatic System

Role: collaborator

NCT02009332Phase 1Completed

Phase 1/2 Study of ABI-009 in Nonmuscle Invasive Bladder Cancer

Role: lead

NCT03657420Phase 1Withdrawn

Safety and Efficacy of ABI-009 (Nab-rapamycin) in Combination With Pomalidomide and Dexamethasone for Relapsed and Refractory Multiple Myeloma

Role: collaborator

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