Success Metrics

Clinical Success Rate
87.0%

Based on 20 completed trials

Completion Rate
87%(20/23)
Active Trials
2(7%)
Results Posted
85%(17 trials)
Terminated
3(10%)

Phase Distribution

Ph phase_1
10
34%
Ph not_applicable
1
3%
Ph phase_2
18
62%

Phase Distribution

10

Early Stage

18

Mid Stage

0

Late Stage

Phase Distribution29 total trials
Phase 1Safety & dosage
10(34.5%)
Phase 2Efficacy & side effects
18(62.1%)
N/ANon-phased studies
1(3.4%)

Highest Phase Reached

Phase 2

Trial Status & Enrollment

Completion Rate

76.9%

20 of 26 finished

Non-Completion Rate

23.1%

6 ended early

Currently Active

2

trials recruiting

Total Trials

29

all time

Status Distribution
Active(2)
Completed(20)
Terminated(6)
Other(1)

Detailed Status

Completed20
Terminated3
Withdrawn3
Active, not recruiting1
Recruiting1
unknown1

Development Timeline

Analytics

Development Status

Total Trials
29
Active
2
Success Rate
87.0%
Most Advanced
Phase 2

Trials by Phase

Phase 110 (34.5%)
Phase 218 (62.1%)
N/A1 (3.4%)

Trials by Status

active_not_recruiting13%
recruiting13%
completed2069%
terminated310%
withdrawn310%
unknown13%

Recent Activity

Clinical Trials (29)

Showing 20 of 29 trialsScroll for more
NCT02298959Phase 1

Testing the PD-1 Antibody, MK3475, Given With Ziv-aflibercept in Patients With Advanced Cancer

Active Not Recruiting
NCT06121180Phase 2

Study of Cemiplimab Plus Ziv-Aflibercept for Subjects With Metastatic Uveal Melanoma

Recruiting
NCT02159989Phase 1

Sapanisertib and Ziv-Aflibercept in Treating Patients With Recurrent Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery

Completed
NCT03712904Phase 2

Stereotactic Body Radiation Therapy and Aflibercept in Treating Patients With Uveal Melanoma

Terminated
NCT01782443Phase 2

Ziv-Aflibercept for Advanced Progressive Carcinoid Tumors

Completed
NCT02101918Phase 2

Ziv-Aflibercept in Treating and Computed Tomography Perfusion Imaging in Predicting Response in Patients With Pancreatic Neuroendocrine Tumors That Are Metastatic or Cannot Be Removed by Surgery

Completed
NCT01747551Phase 2

FOLFOX +/- Ziv-Aflibercept for Esophageal and Gastric Cancer

Completed
NCT00462826Phase 2

VEGF Trap in Treating Patients With Recurrent or Persistent Endometrial Cancer

Completed
NCT01258855Phase 2

Aldesleukin With or Without Ziv-Aflibercept in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed by Surgery

Completed
NCT00436501Phase 1

VEGF Trap and Docetaxel in Treating Patients With Persistent or Recurrent Ovarian Epithelial Cancer, Primary Peritoneal Cancer, or Fallopian Tube Cancer

Completed
NCT02486484Phase 2

Ziv-aflibercept in Ocular Disease Requiring Anti-VEGF Injection

Unknown
NCT00450255Phase 2

VEGF Trap in Treating Patients With Recurrent Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery

Completed
NCT02192541Phase 1

Ganetespib and Ziv-Aflibercept in Refractory Gastrointestinal Carcinomas, Non-Squamous Non-Small Cell Lung Carcinomas, Urothelial Carcinomas, and Sarcomas

Terminated
NCT00828139Phase 2

S0802 - Topotecan With or Without Aflibercept in Treating Patients With Extensive-Stage Small Cell Lung Cancer

Completed
NCT00729157Phase 2

Aflibercept in Treating Patients With Recurrent and/or Metastatic Thyroid Cancer That Did Not Respond to Radioactive Iodine Therapy

Completed
NCT00036946Phase 1

VEGF Trap in Treating Patients With Relapsed or Refractory Solid Tumors or Non-Hodgkin's Lymphoma

Completed
NCT00045266Phase 1

VEGF Trap in Treating Patients With Solid Tumors or Non-Hodgkin's Lymphoma

Completed
NCT00082823Phase 1

Intravenous VEGF Trap in Treating Patients With Relapsed or Refractory Advanced Solid Tumors or Non-Hodgkin's Lymphoma

Completed
NCT00083213Phase 1

Intravenous VEGF Trap in Treating Patients With Relapsed or Refractory Advanced Solid Tumors or Non-Hodgkin's Lymphoma

Completed
NCT00390234Phase 2

Ziv-aflibercept in Treating Patients With Locally Advanced, Unresectable, or Metastatic Gynecologic Soft Tissue Sarcoma

Completed

Drug Details

Intervention Type
BIOLOGICAL
Total Trials
29