Success Metrics

Clinical Success Rate
59.8%

Based on 98 completed trials

Completion Rate
60%(98/164)
Active Trials
307(55%)
Results Posted
82%(80 trials)
Terminated
66(12%)

Phase Distribution

Ph phase_1
247
44%
Ph phase_4
5
1%
Ph early_phase_1
5
1%
Ph not_applicable
17
3%
Ph phase_3
52
9%
Ph phase_2
220
39%

Phase Distribution

252

Early Stage

220

Mid Stage

57

Late Stage

Phase Distribution546 total trials
Early Phase 1First-in-human
5(0.9%)
Phase 1Safety & dosage
247(45.2%)
Phase 2Efficacy & side effects
220(40.3%)
Phase 3Large-scale testing
52(9.5%)
Phase 4Post-market surveillance
5(0.9%)
N/ANon-phased studies
17(3.1%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

51.9%

98 of 189 finished

Non-Completion Rate

48.1%

91 ended early

Currently Active

307

trials recruiting

Total Trials

561

all time

Status Distribution
Active(344)
Completed(98)
Terminated(91)
Other(28)

Detailed Status

Recruiting200
Active, not recruiting107
Completed98
Terminated66
Not yet recruiting36
Withdrawn25

Development Timeline

Analytics

Development Status

Total Trials
561
Active
307
Success Rate
59.8%
Most Advanced
Phase 4

Trials by Phase

Early Phase 15 (0.9%)
Phase 1247 (45.2%)
Phase 2220 (40.3%)
Phase 352 (9.5%)
Phase 45 (0.9%)
N/A17 (3.1%)

Trials by Status

completed9817%
withdrawn254%
not_yet_recruiting366%
enrolling_by_invitation10%
suspended71%
unknown214%
recruiting20036%
terminated6612%
active_not_recruiting10719%

Recent Activity

Clinical Trials (561)

Showing 20 of 561 trialsScroll for more
NCT05834244Phase 1

A Phase Ib Trial of Azacitidine, Venetoclax and Allogeneic NK Cells for Acute Myeloid Leukemia (ADVENT-AML)

Recruiting
NCT06448013Phase 1

A Phase I Study Investigating the Combination of the Menin Inhibitor Ziftomenib With Venetoclax and Gemtuzumab in Pediatric Patients With Acute Myeloid Leukemia

Recruiting
NCT04269902Phase 3

Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

Recruiting
NCT05753501Phase 1

Study to Evaluate Adverse Events, Change in Disease Activity, and How Oral ABBV-101 Moves Through the Body in Adult Participants With B-Cell Malignancies

Active Not Recruiting
NCT04847453Phase 1

Venetoclax, MLN9708 (Ixazomib Citrate) and Dexamethasone for the Treatment of Relapsed or Refractory Light Chain Amyloidosis

Active Not Recruiting
NCT05554393Phase 2

Comparing Cytarabine + Daunorubicin Therapy Versus Cytarabine + Daunorubicin + Venetoclax Versus Venetoclax + Azacitidine in Younger Patients With Intermediate Risk AML (A MyeloMATCH Treatment Trial)

Recruiting
NCT02993523Phase 3

A Study of Venetoclax in Combination With Azacitidine Versus Azacitidine in Treatment Naïve Participants With Acute Myeloid Leukemia Who Are Ineligible for Standard Induction Therapy

Active Not Recruiting
NCT06917911Phase 2

Testing the Addition of Venetoclax or Gemtuzumab Ozogamicin (GO) to Usual Treatment Regimen (Cytarabine and Daunorubicin, "7+3") for Core Binding Factor Acute Myeloid Leukemia (CBF-AML) to Improve Response (A MYELOMATCH Treatment Trial)

Recruiting
NCT06191978Phase 1

A Phase Ia/Ib Open-label, Multiple Dose, Study to Determine the Recommended Dose, Evaluate PKs, PDs, Safety, and Activity of Venetoclax in Combination With Oral Decitabine/Cedazuridine (ASTX727) in Pediatric Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML)

Recruiting
NCT06317649Phase 2

Venetoclax and HMA Treatment of Older and Unfit Adults With FLT3 Mutated Acute Myeloid Leukemia (AML) (A MyeloMATCH Treatment Trial)

Recruiting
NCT03041688Phase 1

Testing a New Chemotherapy Drug, KRT-232 (AMG-232) in Combination With Decitabine and Venetoclax in Patients With Acute Myeloid Leukemia

Active Not Recruiting
NCT04840602Phase 2

Testing the Combination of Venetoclax and Rituximab, in Comparison to the Usual Treatment (Ibrutinib Plus Rituximab or Zanubrutinib Alone) for Waldenstrom's Macroglobulinemia/Lymphoplasmacytic Lymphoma

Recruiting
NCT06672146Phase 2

Comparing New Treatments for People With Newly Diagnosed Acute Myeloid Leukemia That Has an IDH2 Gene Change (A MyeloMATCH Treatment Trial)

Recruiting
NCT05564390Phase 2

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

Recruiting
NCT04746235Phase 2

Venetoclax and ASTX727 for the Treatment of Relapsed, Refractory, or Newly Diagnosed Acute Myeloid Leukemia

Active Not Recruiting
NCT05010122Phase 1

ASTX727, Venetoclax, and Gilteritinib for the Treatment of Newly Diagnosed, Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

Recruiting
NCT04655755Phase 1

Venetoclax in Combination With ASTX727 for the Treatment of Treatment-Naive High-Risk Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia

Active Not Recruiting
NCT07643103Phase 2

Immuno-Targeted Therapy Plus Low-Dose Chemotherapy for Newly Diagnosed Adult Ph-Negative B-ALL: A Prospective Umbrella Trial

Not Yet Recruiting
NCT05554406Phase 2

Testing the Effects of Novel Therapeutics for Newly Diagnosed, Untreated Patients With High-Risk Acute Myeloid Leukemia (A MyeloMATCH Treatment Trial)

Recruiting
NCT06317662Phase 2

Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia

Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
561