Success Metrics

Clinical Success Rate
71.6%

Based on 58 completed trials

Completion Rate
72%(58/81)
Active Trials
16(14%)
Results Posted
78%(45 trials)
Terminated
23(20%)

Phase Distribution

Ph not_applicable
2
2%
Ph phase_1
42
37%
Ph early_phase_1
3
3%
Ph phase_4
1
1%
Ph phase_2
53
47%
Ph phase_3
9
8%

Phase Distribution

45

Early Stage

53

Mid Stage

10

Late Stage

Phase Distribution110 total trials
Early Phase 1First-in-human
3(2.7%)
Phase 1Safety & dosage
42(38.2%)
Phase 2Efficacy & side effects
53(48.2%)
Phase 3Large-scale testing
9(8.2%)
Phase 4Post-market surveillance
1(0.9%)
N/ANon-phased studies
2(1.8%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

66.7%

58 of 87 finished

Non-Completion Rate

33.3%

29 ended early

Currently Active

16

trials recruiting

Total Trials

113

all time

Status Distribution
Active(17)
Completed(58)
Terminated(29)
Other(9)

Detailed Status

Completed58
Terminated23
unknown9
Active, not recruiting8
Recruiting8
Withdrawn6

Development Timeline

Analytics

Development Status

Total Trials
113
Active
16
Success Rate
71.6%
Most Advanced
Phase 4

Trials by Phase

Early Phase 13 (2.7%)
Phase 142 (38.2%)
Phase 253 (48.2%)
Phase 39 (8.2%)
Phase 41 (0.9%)
N/A2 (1.8%)

Trials by Status

completed5851%
active_not_recruiting87%
unknown98%
not_yet_recruiting11%
recruiting87%
terminated2320%
withdrawn65%

Recent Activity

Clinical Trials (113)

Showing 20 of 113 trialsScroll for more
NCT03155620Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)

Active Not Recruiting
NCT02314481Phase 2

Deciphering Antitumour Response and Resistance With INtratumour Heterogeneity

Completed
NCT03554083Phase 2

Vemurafenib, Cobimetinib, Atezolizumab, and Tiragolumab in Treating Patients With High-Risk Stage III Melanoma

Completed
NCT03768063Phase 3

A Study in Patients Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab Study

Active Not Recruiting
NCT01787500Phase 1

Vemurafenib, Cetuximab, and Irinotecan Hydrochloride in Treating Patients With Solid Tumors That Are Metastatic or That Cannot Be Removed by Surgery

Completed
NCT06561360Phase 2

A Study of Vemurafenib and Obinutuzumab Compared to Cladribine and Rituximab in People With Hairy Cell Leukemia (HCL)

Recruiting
NCT05068752Phase 2

Phase II Trial of Vemurafenib and Sorafenib in Pancreatic Cancer

Completed
NCT04943198Phase 2

Optimization of the Time and Dosage of Vemurafenib in BRAF Positive Juvenile Patients With Refractory Histiocytosis

Recruiting
NCT03178552Phase 2

A Study to Evaluate the Efficacy and Safety of Multiple Targeted Therapies as Treatments for Participants With Non-Small Cell Lung Cancer (NSCLC)

Active Not Recruiting
NCT04302025Phase 2

A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)

Recruiting
NCT02721459Phase 1

XL888 + Vemurafenib + Cobimetinib for Unresectable BRAF Mutated Stage III/IV Melanoma

Active Not Recruiting
NCT01909453Phase 3

Study Comparing Combination of LGX818 Plus MEK162 Versus Vemurafenib and LGX818 Monotherapy in BRAF Mutant Melanoma

Completed
NCT01659151Phase 2

Vemurafenib With Lymphodepletion Plus Adoptive Cell Transfer & High Dose IL-2 Metastatic Melanoma

Completed
NCT03410875Phase 2

A Phase II Study of the BRAF Inhibitor, Vemurafenib, Plus Obinutuzumab in Patients With Previously Untreated Classical Hairy Cell Leukemia

Active Not Recruiting
NCT06440850Phase 2

Vemurafenib and Cobimetinib for the Treatment of Patients With High Risk Differentiated Thyroid Carcinoma With BRAFV600E Mutation

Recruiting
NCT03181100Phase 2

Atezolizumab With Chemotherapy in Treating Patients With Anaplastic or Poorly Differentiated Thyroid Cancer

Active Not Recruiting
NCT05768178Phase 2

DETERMINE Trial Treatment Arm 05: Vemurafenib in Combination With Cobimetinib in Adult Patients With BRAF Positive Cancers.

Recruiting
NCT03498521Phase 2

A Phase II Randomized Study Comparing the Efficacy and Safety of Targeted Therapy or Cancer Immunotherapy Versus Platinum-Based Chemotherapy in Patients With Cancer of Unknown Primary Site

Completed
NCT01711632Phase 2

BRAF Inhibitor, Vemurafenib, in Patients With Relapsed or Refractory Hairy Cell Leukemia

Completed
NCT04462471Phase 1

Vemurafenib Plus Copanlisib in Radioiodine-Refractory (RAIR) Thyroid Cancers

Completed

Drug Details

Intervention Type
DRUG
Total Trials
113