Success Metrics

Clinical Success Rate
95.0%

Based on 19 completed trials

Completion Rate
95%(19/20)
Active Trials
2(8%)
Results Posted
63%(12 trials)
Terminated
1(4%)

Phase Distribution

Ph phase_4
1
4%
Ph phase_2
6
23%
Ph phase_1
8
31%
Ph phase_3
11
42%

Phase Distribution

8

Early Stage

6

Mid Stage

12

Late Stage

Phase Distribution26 total trials
Phase 1Safety & dosage
8(30.8%)
Phase 2Efficacy & side effects
6(23.1%)
Phase 3Large-scale testing
11(42.3%)
Phase 4Post-market surveillance
1(3.8%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

82.6%

19 of 23 finished

Non-Completion Rate

17.4%

4 ended early

Currently Active

2

trials recruiting

Total Trials

26

all time

Status Distribution
Active(3)
Completed(19)
Terminated(4)

Detailed Status

Completed19
Withdrawn3
Active, not recruiting2
Not yet recruiting1
Terminated1

Development Timeline

Analytics

Development Status

Total Trials
26
Active
2
Success Rate
95.0%
Most Advanced
Phase 4

Trials by Phase

Phase 18 (30.8%)
Phase 26 (23.1%)
Phase 311 (42.3%)
Phase 41 (3.8%)

Trials by Status

active_not_recruiting28%
not_yet_recruiting14%
completed1973%
withdrawn312%
terminated14%

Recent Activity

Clinical Trials (26)

Showing 20 of 26 trialsScroll for more
NCT07537816Phase 4

Effects of Vadadustat on Anemia, Quality of Life, and Inflammation in Dialysis Patients

Not Yet Recruiting
NCT06520826Phase 3

Vafseo Outcomes In-Center Experience

Active Not Recruiting
NCT06901505Phase 3

To Evaluate the Efficacy of Three Times Weekly (TIW) Vadadustat Compared to Standard of Care ESA in Patients With Anemia of CKD Receiving In-Center Hemodialysis

Active Not Recruiting
NCT05082571Phase 3

Study to Evaluate the Safety and Efficacy of Oral Vadadustat in Pediatric Participants With Anemia of Chronic Kidney Disease

Withdrawn
NCT05082584Phase 3

Study to Evaluate the Safety and Efficacy of Oral Vadadustat in Pediatric Participants With Anemia of Chronic Kidney Disease Naive to Erythropoiesis-Stimulating Agents

Withdrawn
NCT04313153Phase 3

Trial Evaluating the Efficacy and Safety of Oral Vadadustat Once Daily (QD) and Three Times Weekly (TIW) for the Maintenance Treatment of Anemia in Hemodialysis Subjects Converting From Erythropoiesis-Stimulating Agents (ESAs)

Completed
NCT04478071Phase 2

Vadadustat for the Prevention and Treatment of Acute Respiratory Distress Syndrome (ARDS) in Hospitalized Patients With Coronavirus Disease 2019 (COVID-19)

Completed
NCT04707768Phase 3

Study Evaluating the Efficacy and Safety of Dose Conversion From a Long-acting Erythropoiesis-stimulating Agent (Mircera®) to Three Times Weekly Oral Vadadustat for the Maintenance Treatment of Anemia in Hemodialysis Subjects

Completed
NCT03799627Phase 2

Study of Vadadustat in Hemodialysis Participants With Anemia Switching From Epoetin Alfa

Completed
NCT02865850Phase 3

Efficacy and Safety Study to Evaluate Vadadustat for the Correction or Maintenance Treatment of Anemia in Participants With Incident Dialysis-dependent Chronic Kidney Disease (DD-CKD)

Completed
NCT02892149Phase 3

Efficacy and Safety Study to Evaluate Vadadustat for the Maintenance Treatment of Anemia in Participants With Dialysis-dependent Chronic Kidney Disease (DD-CKD)

Completed
NCT04707573Phase 2

Study to Assess the Safety and Pharmacokinetics of AKB-6548 in Participants With Chronic Kidney Disease (CKD), Stages 3 and 4

Completed
NCT02680574Phase 3

Efficacy and Safety Study to Evaluate Vadadustat for the Maintenance Treatment of Anemia in Participants With Non-dialysis-dependent Chronic Kidney Disease (NDD-CKD)

Completed
NCT02648347Phase 3

Study to Evaluate Vadadustat for the Correction of Anemia in Participants With Non-dialysis-dependent Chronic Kidney Disease

Completed
NCT03054350Phase 2

Dose-Finding Study of Vadadustat in Japanese Subjects With Anemia Secondary to Dialysis-Dependent Chronic Kidney Disease (DD-CKD)

Completed
NCT03054337Phase 2

Dose-Finding Study of Vadadustat in Japanese Subjects With Anemia Secondary to Non-Dialysis Dependent Chronic Kidney Disease (NDD-CKD)

Completed
NCT03140722Phase 2

Study to Evaluate Vadadustat for Anemia in Subjects With Dialysis-Dependent Chronic Kidney Disease (DD-CKD) Who Are Hyporesponsive to Erythropoiesis Stimulating Agents

Terminated
NCT04299633Phase 1

Study in Healthy Adult Subjects to Assess the Effect of Phosphate Binders on the Pharmacokinetics of a Single Dose of Vadadustat

Completed
NCT03992066Phase 1

Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Safety of Vadadustat in Hemodialysis Subjects With Anemia Associated With Chronic Kidney Disease

Completed
NCT03789032Phase 1

Study to Evaluate the Effect of Rabeprazole on the Pharmacokinetics of Vadadustat

Completed

Drug Details

Intervention Type
DRUG
Total Trials
26