Success Metrics

Clinical Success Rate
44.4%

Based on 4 completed trials

Completion Rate
44%(4/9)
Active Trials
2(18%)
Results Posted
125%(5 trials)
Terminated
5(45%)

Phase Distribution

Ph phase_1
7
64%
Ph phase_2
2
18%
Ph phase_3
2
18%

Phase Distribution

7

Early Stage

2

Mid Stage

2

Late Stage

Phase Distribution11 total trials
Phase 1Safety & dosage
7(63.6%)
Phase 2Efficacy & side effects
2(18.2%)
Phase 3Large-scale testing
2(18.2%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

44.4%

4 of 9 finished

Non-Completion Rate

55.6%

5 ended early

Currently Active

2

trials recruiting

Total Trials

11

all time

Status Distribution
Active(2)
Completed(4)
Terminated(5)

Detailed Status

Terminated5
Completed4
Active, not recruiting2

Development Timeline

Analytics

Development Status

Total Trials
11
Active
2
Success Rate
44.4%
Most Advanced
Phase 3

Trials by Phase

Phase 17 (63.6%)
Phase 22 (18.2%)
Phase 32 (18.2%)

Trials by Status

completed436%
active_not_recruiting218%
terminated545%

Recent Activity

Clinical Trials (11)

Showing 11 of 11 trials
NCT05146739Phase 1

Highest Dose of Uproleselan in Combination With Fludarabine and Cytarabine for Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Mixed Phenotype Acute Leukemia Relapsed or Refractory That Expresses E-selectin Ligand on the Cell Membrane

Active Not Recruiting
NCT04964505Phase 1

Uproleselan, Azacitidine, and Venetoclax for the Treatment of Treatment Naive Acute Myeloid Leukemia

Terminated
NCT03701308Phase 2

Daunorubicin and Cytarabine With or Without Uproleselan in Treating Older Adult Patients With Acute Myeloid Leukemia Receiving Intensive Induction Chemotherapy

Active Not Recruiting
NCT04848974Phase 1

Uproleselan, Cladribine, and Low Dose Cytarabine for the Treatment of Patients With Treated Secondary Acute Myeloid Leukemia

Completed
NCT04839341Phase 1

Study to Evaluate PK and Safety With Uproleselan Combined With Chemotherapy to Treat Chinese R/R AML Patients

Completed
NCT05054543Phase 3

Study to Evaluate the Efficacy of Uproleselan in Combination With Chemotherapy in Chinese Patients With R/R AML

Terminated
NCT05569512Phase 1

Uproleselan With Pre-Transplant Conditioning in Hematopoietic Stem Cell Transplantation for AML

Terminated
NCT03616470Phase 3

Study to Determine the Efficacy of Uproleselan (GMI-1271) in Combination With Chemotherapy to Treat Relapsed/Refractory Acute Myeloid Leukemia

Terminated
NCT04682405Phase 2

Uproleselan (GMI-1271) for GI Toxicity Prophylaxis During Melphalan-Conditioned Autologous Hematopoietic Cell Transplantation (Auto-HCT) for Multiple Myeloma (MM)

Completed
NCT05057221Phase 1

Safety, Tolerability and Efficacy of Uproleselan (GMI-1271) in Patients With COVID-19 Pneumonia

Terminated
NCT03606447Phase 1

A Study in Healthy Volunteers to Investigate How Much Test Medicine [14C]-Uproleselan is Taken up by the Body When Administered Directly Into the Vein (IV)

Completed

All 11 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
11