Success Metrics

Clinical Success Rate
47.8%

Based on 11 completed trials

Completion Rate
48%(11/23)
Active Trials
11(29%)
Results Posted
136%(15 trials)
Terminated
12(32%)

Phase Distribution

Ph phase_2
14
37%
Ph phase_3
7
18%
Ph phase_4
2
5%
Ph early_phase_1
1
3%
Ph not_applicable
1
3%
Ph phase_1
12
32%

Phase Distribution

13

Early Stage

14

Mid Stage

9

Late Stage

Phase Distribution37 total trials
Early Phase 1First-in-human
1(2.7%)
Phase 1Safety & dosage
12(32.4%)
Phase 2Efficacy & side effects
14(37.8%)
Phase 3Large-scale testing
7(18.9%)
Phase 4Post-market surveillance
2(5.4%)
N/ANon-phased studies
1(2.7%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

44.0%

11 of 25 finished

Non-Completion Rate

56.0%

14 ended early

Currently Active

11

trials recruiting

Total Trials

38

all time

Status Distribution
Active(13)
Completed(11)
Terminated(14)

Detailed Status

Terminated12
Completed11
Recruiting7
Active, not recruiting4
Withdrawn2
Not yet recruiting2

Development Timeline

Analytics

Development Status

Total Trials
38
Active
11
Success Rate
47.8%
Most Advanced
Phase 4

Trials by Phase

Early Phase 11 (2.7%)
Phase 112 (32.4%)
Phase 214 (37.8%)
Phase 37 (18.9%)
Phase 42 (5.4%)
N/A1 (2.7%)

Trials by Status

terminated1232%
withdrawn25%
completed1129%
recruiting718%
not_yet_recruiting25%
active_not_recruiting411%

Recent Activity

Clinical Trials (38)

Showing 20 of 38 trialsScroll for more
NCT04130997Phase 3

An Extension Study of Ublituximab in Participants With Relapsing Multiple Sclerosis

Active Not Recruiting
NCT05877963Phase 3

Study to Evaluate Safety, Efficacy and Pharmacokinetics (PK) of a Modified Regimen of Ublituximab

Recruiting
NCT07211633Phase 3

A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety, Radiological and Clinical Effects of Subcutaneous Ublituximab in Participants With Relapsing Multiple Sclerosis (RMS)

Active Not Recruiting
NCT07220252Phase 2

Study to Assess Effects of Ublituximab in Pediatric Participants With Relapsing Forms of Multiple Sclerosis

Not Yet Recruiting
NCT07389590Phase 4

Study of Ublituximab for Ocrelizumab Wearing-Off in Multiple Sclerosis

Recruiting
NCT06864936Not Applicable

Exploration of Novel Imaging Biomarkers on OCT for Ublituximab Treatment Response in Multiple Sclerosis

Recruiting
NCT07103746Phase 2

Ublituximab in Autoantibody Positive Immune Mediated Necrotizing Myopathy

Recruiting
NCT07503873Phase 2

A Study to Evaluate Pharmacokinetics (PK) and Safety of Subcutaneous (SC) Ublituximab Administered at Various Injection Sites and Relative Bioavailability Via Autoinjector (AI) Versus Syringe Subcutaneously in Participants With Multiple Sclerosis (MS)

Not Yet Recruiting
NCT07225361Phase 4

Ublituximab (Briumvi) for Early Forms of Relapsing Multiple Sclerosis

Recruiting
NCT04624633Phase 2

Acalabrutinib, Umbralisib, and Ublituximab (AU2) In Relapsed and Untreated CLL

Active Not Recruiting
NCT06629428Early Phase 1

Effects of Ublituximab on Motor Functions in Multiple Sclerosis

Recruiting
NCT02612311Phase 3

Ublituximab + TGR-1202 Compared to Obinutuzumab + Chlorambucil in Participants With Untreated and Previously Treated Chronic Lymphocytic Leukemia

Terminated
NCT04783415Phase 2

Acalabrutinib, Umbralisib, and Ublituximab for the Treatment of Previously Untreated Mantle Cell Lymphoma

Active Not Recruiting
NCT06681623

A Single-Center Study to Characterize the Safety and Efficacy of Ublituximab in Older Adults With Relapsing Forms of Multiple Sclerosis (RMS)

Recruiting
NCT04806035Phase 1

Study of TG-1801 Alone or in Combination With Ublituximab in Subjects With B-Cell Lymphoma or Chronic Lymphocytic Leukemia

Terminated
NCT03671590Phase 1

Study of TG-1701, an Irreversible Bruton's Tyrosine Kinase Inhibitor, in Patients With B-Cell Malignancies

Terminated
NCT03801525Phase 2

Study to Assess the Efficacy and Safety of Ublituximab in Combination With Umbralisib and Venetoclax Compared to Ublituximab in Combination With Umbralisib in Subjects With CLL (ULTRA-V)

Terminated
NCT03804996Phase 1

Study of TG-1801 in Subjects With B-Cell Lymphoma

Completed
NCT04508647Phase 2

Ublituximab Followed by Response-driven Addition of Umbralisib for Treatment-naive Follicular or Marginal Zone Lymphoma

Completed
NCT04692155Phase 1

Clinical Trial of Ublituximab and Umbralisib With CHOP (U2-CHOP) Followed by U2 Maintenance (U2-CHOP-U2) in Previously Untreated Mantle Cell Lymphoma (MCL)

Terminated

Drug Details

Intervention Type
BIOLOGICAL
Total Trials
38