Success Metrics

Clinical Success Rate
66.7%

Based on 12 completed trials

Completion Rate
67%(12/18)
Active Trials
3(13%)
Results Posted
92%(11 trials)
Terminated
6(25%)

Phase Distribution

Ph phase_2
12
50%
Ph phase_1
5
21%
Ph phase_4
1
4%
Ph phase_3
4
17%

Phase Distribution

5

Early Stage

12

Mid Stage

5

Late Stage

Phase Distribution22 total trials
Phase 1Safety & dosage
5(22.7%)
Phase 2Efficacy & side effects
12(54.5%)
Phase 3Large-scale testing
4(18.2%)
Phase 4Post-market surveillance
1(4.5%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

63.2%

12 of 19 finished

Non-Completion Rate

36.8%

7 ended early

Currently Active

3

trials recruiting

Total Trials

24

all time

Status Distribution
Active(5)
Completed(12)
Terminated(7)

Detailed Status

Completed12
Terminated6
Not yet recruiting2
Recruiting2
Active, not recruiting1
Withdrawn1

Development Timeline

Analytics

Development Status

Total Trials
24
Active
3
Success Rate
66.7%
Most Advanced
Phase 4

Trials by Phase

Phase 15 (22.7%)
Phase 212 (54.5%)
Phase 34 (18.2%)
Phase 41 (4.5%)

Trials by Status

not_yet_recruiting28%
recruiting28%
active_not_recruiting14%
terminated625%
completed1250%
withdrawn14%

Recent Activity

Clinical Trials (24)

Showing 20 of 24 trialsScroll for more
NCT07565324Phase 2

Phase II Study of Ultrasound and ctDNA Guided Neoadjuvant Systemic Therapy for Patients With HER2-positive Early Breast Cancer (UC HER Trial)

Not Yet Recruiting
NCT07527806Phase 2

Optimization of Dynamic Neoadjuvant Therapy Strategies for HER2-Positive Breast Cancer Based on HER2-PET/CT Molecular Imaging

Not Yet Recruiting
NCT06663787

Personalized Detection of ctDNA for Patients With HER2-Positive Metastatic Breast Cancer Who Achieved Durable Response by Anti-HER2 Treatment (HER2 CR)

Active Not Recruiting
NCT07193394Phase 2

Tucatinib and Trastuzumab in HER3-mutant and HER2-not Amplified Metastatic Breast Cancer

Recruiting
NCT06876714Phase 3

ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab

Recruiting
NCT01120184Phase 3

A Study of Trastuzumab Emtansine (T-DM1) Plus Pertuzumab/Pertuzumab Placebo Versus Trastuzumab [Herceptin] Plus a Taxane in Participants With Metastatic Breast Cancer (MARIANNE)

Completed
NCT02402712Phase 3

Phase IIIb Study to Evaluate the Safety and Tolerability of Herceptin SC With Perjeta and Docetaxel in Patients With HER2-positive Advanced Breast Cancer

Completed
NCT00885755Phase 2

A Study of Herceptin (Trastuzumab)and Biomarkers in Patients With HER2-Positive Metastatic Breast Cancer

Completed
NCT01152606

A Study of Cardiac Safety in Patients With HER2 Positive Early Breast Cancer Treated With Herceptin

Completed
NCT01344863Phase 1

A Study of Administration of Trastuzumab (Herceptin) by a Single-use Injection Device Versus a Handheld Syringe

Completed
NCT00964704Phase 2

A Study of Herceptin (Trastuzumab) in Combination With Avastin (Bevacizumab) and Sequential Xeloda (Capecitabine) or Docetaxel in Patients With HER2-Positive Locally Recurrent or Metastatic Breast Cancer

Withdrawn
NCT01260194Phase 4

A Study of Herceptin (Trastuzumab) in Combination With Standard Chemotherapy in Patients With HER Positive Metastatic Gastric Cancer

Terminated
NCT00811993Phase 1

A Study of R1507 in Combination With Multiple Standard Chemotherapy Treatments in Patients With Advanced Solid Tumors

Terminated
NCT00811135Phase 2

A Study of Avastin (Bevacizumab) in Combination With Herceptin (Trastuzumab) and Xeloda (Capecitabine) in Patients With HER2-Positive Breast Cancer

Completed
NCT00717405Phase 2

A Study of Avastin (Bevacizumab) Plus Herceptin (Trastuzumab) in Patients With Primary Inflammatory HER2-Positive Breast Cancer.

Completed
NCT00444587Phase 2

A Study of Herceptin (Trastuzumab) in Combination With 2nd-Line Chemotherapy in Patients With HER2 Positive Metastatic Breast Cancer.

Completed
NCT01454804Phase 1

Pazopanib, Lapatinib or Trastuzumab in Subjects With Solid Tumors

Completed
NCT01130337Phase 2

A Study of Capecitabine [Xeloda] in Combination With Trastuzumab [Herceptin] and Oxaliplatine in Patients With Resectable Gastric Cancer

Completed
NCT01290718Phase 2

A Study of Herceptin (Trastuzumab) in Combination With Xeloda (Capecitabine) in Patients With Metastatic or Recurrent HER2-positive Breast Cancer After First-Line or (Neo)Adjuvant Therapy.

Terminated
NCT01363986Phase 2

A Study of Herceptin (Trastuzumab) in Combination With Whole Brain Radiotherapy in Patients With HER-2 Positive Breast Cancer

Terminated

Drug Details

Intervention Type
DRUG
Total Trials
24