Success Metrics

Clinical Success Rate
71.4%

Based on 25 completed trials

Completion Rate
71%(25/35)
Active Trials
23(35%)
Results Posted
92%(23 trials)
Terminated
10(15%)

Phase Distribution

Ph phase_2
30
45%
Ph phase_3
16
24%
Ph early_phase_1
1
2%
Ph phase_4
1
2%
Ph phase_1
13
20%
Ph not_applicable
1
2%

Phase Distribution

14

Early Stage

30

Mid Stage

17

Late Stage

Phase Distribution62 total trials
Early Phase 1First-in-human
1(1.6%)
Phase 1Safety & dosage
13(21.0%)
Phase 2Efficacy & side effects
30(48.4%)
Phase 3Large-scale testing
16(25.8%)
Phase 4Post-market surveillance
1(1.6%)
N/ANon-phased studies
1(1.6%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

64.1%

25 of 39 finished

Non-Completion Rate

35.9%

14 ended early

Currently Active

23

trials recruiting

Total Trials

66

all time

Status Distribution
Active(23)
Completed(25)
Terminated(14)
Other(4)

Detailed Status

Completed25
Recruiting13
Terminated10
Active, not recruiting10
Withdrawn4
unknown4

Development Timeline

Analytics

Development Status

Total Trials
66
Active
23
Success Rate
71.4%
Most Advanced
Phase 4

Trials by Phase

Early Phase 11 (1.6%)
Phase 113 (21.0%)
Phase 230 (48.4%)
Phase 316 (25.8%)
Phase 41 (1.6%)
N/A1 (1.6%)

Trials by Status

recruiting1320%
withdrawn46%
terminated1015%
unknown46%
active_not_recruiting1015%
completed2538%

Recent Activity

Clinical Trials (66)

Showing 20 of 66 trialsScroll for more
NCT06324357Phase 1

Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread

Recruiting
NCT02465060Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

Active Not Recruiting
NCT02390427Phase 1

Phase Ib Dose-escalation Trial of Taselisib (GDC-0032) in Combination With Anti-HER2 Therapies in Participants With Advanced HER2+ Breast Cancer

Completed
NCT04589845Phase 2

Tumor-agnostic Precision Immuno-oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study

Active Not Recruiting
NCT04486352Phase 1

A Study of Targeted Agents for Patients With Recurrent or Persistent Endometrial Cancer

Recruiting
NCT04266249Phase 2

CompassHER2-pCR: Decreasing Chemotherapy for Breast Cancer Patients After Pre-surgery Chemo and Targeted Therapy

Active Not Recruiting
NCT04931342Phase 2

A Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurrent Rare Epithelial Ovarian Tumors

Active Not Recruiting
NCT04873362Phase 3

A Study Evaluating the Efficacy and Safety of Adjuvant Atezolizumab or Placebo and Trastuzumab Emtansine for Participants With HER2-Positive Breast Cancer at High Risk of Recurrence Following Preoperative Therapy

Active Not Recruiting
NCT01853748Phase 2

T-DM1 vs Paclitaxel/Trastuzumab for Breast (ATEMPT Trial)

Completed
NCT06595563Phase 2

HER2 Molecular Imaging With 89Zr-trastuzumab PET/CT as a Predictive Biomarker for Antibody-drug Conjugate Sequencing in Patients With Advanced HER2-positive Breast Cancer

Recruiting
NCT06348134Phase 2

Assessing the Efficacy and Safety of Anti-HER2 Therapy in Nigerian Women With HER2+ Breast Cancer Before and After Surgery

Recruiting
NCT05415215Phase 3

A Study to Evaluate Patient Preference for Home Administration of Fixed-Dose Combination of Pertuzumab and Trastuzumab for Subcutaneous Administration in Participants With Early or Locally Advanced/Inflammatory HER2-Positive Breast Cancer

Completed
NCT07389876

Albumin-bound Paclitaxel-based Second-line Treatment Regimens for Locally Advanced or Metastatic G/GEJ Adenocarcinoma

Recruiting
NCT05673928Phase 2

A Phase II Study of Tucatinib and Ado-trastuzumab Emtansine (T-DM1) in Patients With HER2-positive Metastatic Solid Tumors and Metastases to Brain (TUCATEMEB)

Recruiting
NCT05408845Phase 2

Testing the Use of Ado-Trastuzumab Emtansine Compared to the Usual Treatment (Chemotherapy With Docetaxel Plus Trastuzumab) or Trastuzumab Deruxtecan for Recurrent, Metastatic, or Unresectable HER2-Expressing Salivary Gland Cancers

Recruiting
NCT00781612Phase 2

A Safety Extension Study of Trastuzumab Emtansine in Participants Previously Treated With Trastuzumab Emtansine Alone or in Combination With Other Anti-Cancer Therapy in One of the Parent Studies

Active Not Recruiting
NCT01975142Phase 2

Validity of HER2-amplified Circulating Tumor Cells to Select Metastatic Breast Cancer Considered HER2-negative for Trastuzumab-emtansine (T-DM1) Treatment.

Completed
NCT04439110Phase 2

Testing Ado-Trastuzumab Emtansine as a Potential Targeted Treatment in Cancers With HER2 Genetic Changes (MATCH-Subprotocol Q)

Active Not Recruiting
NCT04457596Phase 3

T-DM1 and Tucatinib Compared With T-DM1 Alone in Preventing Relapses in People With High Risk HER2-Positive Breast Cancer, the CompassHER2 RD Trial

Active Not Recruiting
NCT04419181Phase 2

Feasibility of Chemotherapy De-escalation in Early-Stage HER2 Positive Breast Cancer

Withdrawn

Drug Details

Intervention Type
DRUG
Total Trials
66