Success Metrics

Clinical Success Rate
86.7%

Based on 104 completed trials

Completion Rate
87%(104/120)
Active Trials
8(6%)
Results Posted
28%(29 trials)
Terminated
16(11%)

Phase Distribution

Ph phase_2
64
45%
Ph not_applicable
5
3%
Ph phase_1
57
40%
Ph phase_3
17
12%

Phase Distribution

57

Early Stage

64

Mid Stage

17

Late Stage

Phase Distribution143 total trials
Phase 1Safety & dosage
57(39.9%)
Phase 2Efficacy & side effects
64(44.8%)
Phase 3Large-scale testing
17(11.9%)
N/ANon-phased studies
5(3.5%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

81.3%

104 of 128 finished

Non-Completion Rate

18.8%

24 ended early

Currently Active

8

trials recruiting

Total Trials

143

all time

Status Distribution
Active(8)
Completed(104)
Terminated(24)
Other(7)

Detailed Status

Completed104
Terminated16
Withdrawn8
Active, not recruiting7
unknown7
Recruiting1

Development Timeline

Analytics

Development Status

Total Trials
143
Active
8
Success Rate
86.7%
Most Advanced
Phase 3

Trials by Phase

Phase 157 (39.9%)
Phase 264 (44.8%)
Phase 317 (11.9%)
N/A5 (3.5%)

Trials by Status

completed10473%
active_not_recruiting75%
unknown75%
recruiting11%
terminated1611%
withdrawn86%

Recent Activity

Clinical Trials (143)

Showing 20 of 143 trialsScroll for more
NCT02502266Phase 2

Testing the Combination of Cediranib and Olaparib in Comparison to Each Drug Alone or Other Chemotherapy in Recurrent Platinum-Resistant Ovarian Cancer

Active Not Recruiting
NCT01012817Phase 1

Veliparib and Topotecan Hydrochloride in Treating Patients With Solid Tumors, Relapsed or Refractory Ovarian Cancer, or Primary Peritoneal Cancer

Active Not Recruiting
NCT03896503Phase 2

Randomized Trial of Topotecan With M6620, an ATR Kinase Inhibitor, in Small Cell Lung Cancers and Small Cell Cancers Outside of the Lungs

Active Not Recruiting
NCT03289910Phase 2

Topotecan Hydrochloride and Carboplatin With or Without Veliparib in Treating Advanced Myeloproliferative Disorders and Acute Myeloid Leukemia or Chronic Myelomonocytic Leukemia

Active Not Recruiting
NCT04739800Phase 2

Comparison of Standard of Care Treatment With a Triplet Combination of Targeted Immunotherapeutic Agents

Active Not Recruiting
NCT05353439Phase 1

Testing of Tazemetostat in Combination With Topotecan and Pembrolizumab in Patients With Recurrent Small Cell Lung Cancer

Active Not Recruiting
NCT03126916Phase 3

Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)

Recruiting
NCT01231906Phase 3

Combination Chemotherapy in Treating Patients With Non-Metastatic Extracranial Ewing Sarcoma

Completed
NCT01175356Phase 1

Induction Therapy Including 131 I-MIBG and Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma Undergoing Stem Cell Transplant, Radiation Therapy, and Maintenance Therapy With Isotretinoin

Completed
NCT02364713Phase 2

MV-NIS or Investigator's Choice Chemotherapy in Treating Patients With Ovarian, Fallopian, or Peritoneal Cancer

Terminated
NCT02569957Phase 2

Effect of Acetylcysteine With Topotecan Hydrochloride on the Tumor Microenvironment in Patients With Persistent or Recurrent High Grade Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

Terminated
NCT00588991Phase 1

Veliparib and Topotecan With or Without Carboplatin in Treating Patients With Relapsed or Refractory Acute Leukemia, High-Risk Myelodysplasia, or Aggressive Myeloproliferative Disorders

Completed
NCT00638898Phase 1

Busulfan, Melphalan, Topotecan Hydrochloride, and a Stem Cell Transplant in Treating Patients With Newly Diagnosed or Relapsed Solid Tumor

Completed
NCT04514497Phase 1

Testing the Addition of an Anti-cancer Drug, BAY 1895344, to Usual Chemotherapy for Advanced Stage Solid Tumors, With a Specific Focus on Patients With Small Cell Lung Cancer, Poorly Differentiated Neuroendocrine Cancer, and Pancreatic Cancer

Active Not Recruiting
NCT02312245Phase 2

Avatar-Directed Chemotherapy in Treating Patients With Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

Completed
NCT01798004Phase 1

Busulfan, Melphalan, and Stem Cell Transplant After Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma

Completed
NCT01606878Phase 1

Crizotinib and Combination Chemotherapy in Treating Younger Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma

Completed
NCT05295589Phase 2

Comparing Standard of Care Chemotherapy Treatment to the Combination of Copanlisib and Olaparib for Recurrent Platinum Resistant Ovarian Cancer That Has Progressed Through PARP Inhibitor Therapy

Withdrawn
NCT00856037Phase 1

Topotecan Hydrochloride and Doxorubicin Hydrochloride in Treating Relapsed or Refractory Small Cell Lung Cancer

Completed
NCT00005962Phase 2

Comparison of Three Treatment Regimens in Treating Patients With Relapsed or Refractory Acute Myelogenous Leukemia

Completed

Drug Details

Intervention Type
DRUG
Total Trials
143