Success Metrics

Clinical Success Rate
68.4%

Based on 13 completed trials

Completion Rate
68%(13/19)
Active Trials
4(15%)
Results Posted
92%(12 trials)
Terminated
6(22%)

Phase Distribution

Ph phase_1
10
37%
Ph phase_2
12
44%
Ph phase_3
3
11%
Ph not_applicable
2
7%

Phase Distribution

10

Early Stage

12

Mid Stage

3

Late Stage

Phase Distribution27 total trials
Phase 1Safety & dosage
10(37.0%)
Phase 2Efficacy & side effects
12(44.4%)
Phase 3Large-scale testing
3(11.1%)
N/ANon-phased studies
2(7.4%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

59.1%

13 of 22 finished

Non-Completion Rate

40.9%

9 ended early

Currently Active

4

trials recruiting

Total Trials

27

all time

Status Distribution
Active(5)
Completed(13)
Terminated(9)

Detailed Status

Completed13
Terminated6
Recruiting4
Withdrawn3
Not yet recruiting1

Development Timeline

Analytics

Development Status

Total Trials
27
Active
4
Success Rate
68.4%
Most Advanced
Phase 3

Trials by Phase

Phase 110 (37.0%)
Phase 212 (44.4%)
Phase 33 (11.1%)
N/A2 (7.4%)

Trials by Status

terminated622%
withdrawn311%
recruiting415%
not_yet_recruiting14%
completed1348%

Recent Activity

Clinical Trials (27)

Showing 20 of 27 trialsScroll for more
NCT04645160Phase 1

Evaluating Efficacy of Tivozanib (AV-951) in Biliary Tract Cancers

Recruiting
NCT06661720Phase 3

Testing the Addition of the Anti-Cancer Drug Tivozanib to Immunotherapy (Pembrolizumab) After Surgery to Remove All Known Sites of Kidney Cancer

Recruiting
NCT05000294Phase 1

Atezolizumab Plus Tivozanib in Immunologically Cold Tumor Types

Recruiting
NCT06053658Phase 2

Phase 2 Study of Combination Tivozanib and Nivolumab in Advanced Non-Clear Cell Renal Cell Carcinoma

Recruiting
NCT01885949Phase 2

Tivozanib + Enzalutamide in Adv Prostate Cancer

Terminated
NCT04987203Phase 3

Study to Compare Tivozanib in Combination With Nivolumab to Tivozanib Monotherapy in Subjects With Renal Cell Carcinoma

Completed
NCT07218692Phase 2

RP2 and Tivozanib for the Treatment of Metastatic Renal Cell Cancer After Progression on Immunotherapy

Not Yet Recruiting
NCT03970616Phase 1

A Study of Tivozanib in Combination With Durvalumab in Subjects With Advanced Hepatocellular Carcinoma

Terminated
NCT01769885Not Applicable

Tivozanib Before Surgery in Treating Patients With Localized Kidney Cancer

Withdrawn
NCT03136627Phase 1

Phase 1/2 Study of Tivozanib in Combination With Nivolumab in Subjects With RCC

Completed
NCT01853644Phase 2

Tivozanib in Recurrent, Platinum-Resistant Ovarian, Fallopian Tube or Primary Peritoneal Cancer

Completed
NCT01297244Phase 2

A Biomarker Study of Tivozanib in Subjects With Advanced Renal Cell Carcinoma

Completed
NCT01673386Phase 2

A Subject Treatment Preference Study of Tivozanib Versus Sunitinib in Subjects With Metastatic RCC

Terminated
NCT01076010Phase 3

An Extension Treatment Protocol for Subjects Who Have Participated in a Study of Tivozanib Versus Sorafenib in Kidney Carcinoma (Protocol AV-951-09-301).

Completed
NCT01369433Not Applicable

A Rollover Protocol to Allow Continued Access to Tivozanib (AV 951) for Subjects Enrolled in Other Tivozanib Protocols

Terminated
NCT01782313Phase 2

A Phase II Study of Tivozanib in Patients With Metastatic and Non-resectable Soft Tissue Sarcomas

Completed
NCT01846871Phase 2

Tivozanib for Recurrent Glioblastoma

Completed
NCT01972516Phase 2

Tivozanib As Maintenance Therapy In GYN

Terminated
NCT01058655Phase 1

RAD001 and AV-951 in Patients With Refractory, Metastatic Colorectal Cancer

Completed
NCT01807156Phase 2

Phase II Trial of Tivozanib in Advanced Hepatocellular Cancer

Terminated

Drug Details

Intervention Type
DRUG
Total Trials
27