Success Metrics

Clinical Success Rate
89.5%

Based on 17 completed trials

Completion Rate
89%(17/19)
Active Trials
0(0%)
Results Posted
65%(11 trials)
Terminated
2(11%)

Phase Distribution

Ph phase_1
11
58%
Ph phase_2
6
32%
Ph phase_3
2
11%

Phase Distribution

11

Early Stage

6

Mid Stage

2

Late Stage

Phase Distribution19 total trials
Phase 1Safety & dosage
11(57.9%)
Phase 2Efficacy & side effects
6(31.6%)
Phase 3Large-scale testing
2(10.5%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

89.5%

17 of 19 finished

Non-Completion Rate

10.5%

2 ended early

Currently Active

0

trials recruiting

Total Trials

19

all time

Status Distribution
Completed(17)
Terminated(2)

Detailed Status

Completed17
Terminated2

Development Timeline

Analytics

Development Status

Total Trials
19
Active
0
Success Rate
89.5%
Most Advanced
Phase 3

Trials by Phase

Phase 111 (57.9%)
Phase 26 (31.6%)
Phase 32 (10.5%)

Trials by Status

completed1789%
terminated211%

Recent Activity

Clinical Trials (19)

Showing 19 of 19 trials
NCT01075048Phase 1

ARQ 197 in Combination With Chemotherapy in Patients With Metastatic Colorectal Cancer

Completed
NCT01244191Phase 3

Tivantinib Plus Erlotinib Versus Placebo Plus Erlotinib for the Treatment of Non-squamous, Non-small-cell Lung Cancer

Terminated
NCT01755767Phase 3

Study of Tivantinib in Subjects With Inoperable Hepatocellular Carcinoma (HCC) Who Have Been Treated With One Prior Therapy

Completed
NCT01178411Phase 1

An Extension Protocol for Subjects Who Were Previously Enrolled in Other Tivantinib (ARQ 197) Protocols

Completed
NCT02049060Phase 1

Study of the Combination of Tivantinib Plus Pemetrexed and Carboplatin

Completed
NCT01447914Phase 2

Tivantinib in Treating Patients With Relapsed, or Relapsed and Refractory Multiple Myeloma

Completed
NCT01517399Phase 1

Drug-drug Interaction Study of Tivantinib (ARQ 197) With Omeprazole, S-warfarin, Caffeine, Midazolam, and Digoxin in Cancer Subjects

Completed
NCT01699061Phase 1

Effect of Tivantinib on the QTC Interval in Cancer Subjects

Completed
NCT02150733Phase 1

Pharmacokinetics of Tivantinib in Subjects With Advanced Solid Tumors and Hepatic Impairment

Completed
NCT01688973Phase 2

Tivantinib With or Without Erlotinib Hydrochloride in Treating Patients With Metastatic or Locally Advanced Kidney Cancer That Cannot Be Removed by Surgery

Completed
NCT01696955Phase 2

Cetuximab With or Without Tivantinib in Treating Patients With Head and Neck Cancer That Is Recurrent, Metastatic, or Cannot Be Removed by Surgery

Completed
NCT01519414Phase 2

Tivantinib in Treating Patients With Metastatic Prostate Cancer

Completed
NCT01654965Phase 1

Tivantinib and Topotecan Hydrochloride in Treating Patients With Advanced or Metastatic Solid Tumors

Completed
NCT01749384Phase 1

Tivantinib and Bevacizumab in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery

Completed
NCT01611857Phase 1

Phase I/II Trial of Tivantinib With FOLFOX for the Treatment of Advanced Solid Tumors and Previously Untreated Metastatic Adenocarcinoma of the Distal Esophagus, Gastroesophageal Junction or Stomach

Completed
NCT01861301Phase 2

Tivantinib in Treating Patients With Previously Treated Malignant Mesothelioma

Terminated
NCT01575522Phase 2

Tivantinib in Treating Patients With Recurrent or Metastatic Breast Cancer

Completed
NCT01625156Phase 1

Tivantinib and Temsirolimus in Treating Patients With Solid Tumors That is Metastatic or Cannot be Removed by Surgery

Completed
NCT01725191Phase 1

Tivantinib in Treating Younger Patients With Relapsed or Refractory Solid Tumors

Completed

All 19 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
19