Success Metrics

Clinical Success Rate
72.4%

Based on 21 completed trials

Completion Rate
72%(21/29)
Active Trials
24(41%)
Results Posted
81%(17 trials)
Terminated
8(14%)

Phase Distribution

Ph phase_2
30
51%
Ph phase_3
9
15%
Ph phase_1
20
34%

Phase Distribution

20

Early Stage

30

Mid Stage

9

Late Stage

Phase Distribution59 total trials
Phase 1Safety & dosage
20(33.9%)
Phase 2Efficacy & side effects
30(50.8%)
Phase 3Large-scale testing
9(15.3%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

63.6%

21 of 33 finished

Non-Completion Rate

36.4%

12 ended early

Currently Active

24

trials recruiting

Total Trials

59

all time

Status Distribution
Active(24)
Completed(21)
Terminated(12)
Other(2)

Detailed Status

Completed21
Active, not recruiting15
Recruiting9
Terminated8
Withdrawn4
unknown2

Development Timeline

Analytics

Development Status

Total Trials
59
Active
24
Success Rate
72.4%
Most Advanced
Phase 3

Trials by Phase

Phase 120 (33.9%)
Phase 230 (50.8%)
Phase 39 (15.3%)

Trials by Status

unknown23%
withdrawn47%
terminated814%
recruiting915%
completed2136%
active_not_recruiting1525%

Recent Activity

Clinical Trials (59)

Showing 20 of 59 trialsScroll for more
NCT04665843Phase 2

A Study of Atezolizumab Plus Tiragolumab and Atezolizumab Plus Placebo as First-Line Treatment in Participants With Recurrent/Metastatic PD-L1 Positive Squamous Cell Carcinoma of the Head and Neck

Completed
NCT03784326Phase 2

Phase I/II Study of Perioperative Chemotherapy Plus Immunotherapy Followed by Surgery in Localized Esophageal and Gastroesophageal Adenocarcinoma

Active Not Recruiting
NCT05681039Phase 2

Phase 2 Trial of Neoadjuvant and Adjuvant Tiragolumab Plus Atezolizumab in Patients With Newly Diagnosed PD-L1 CPS Positive Resectable Stage 3-4 Oral Cavity Squamous Cell Carcinoma (OCSCC).

Recruiting
NCT05394337Phase 1

Neoadjuvant PD-1 Plus TIGIT Blockade in Patients With Cisplatin-Ineligible Operable High-Risk Urothelial Carcinoma

Recruiting
NCT03554083Phase 2

Vemurafenib, Cobimetinib, Atezolizumab, and Tiragolumab in Treating Patients With High-Risk Stage III Melanoma

Completed
NCT03563716Phase 2

A Study of Tiragolumab in Combination With Atezolizumab in Chemotherapy-Naïve Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Completed
NCT05645692Phase 2

A Study Evaluating Different Immunotherapies (LAG-3 and PD-1 With or Without TIGIT, Compared to PD-L1 Alone) in Participants With Untreated Locally Advanced Metastatic Urothelial Cancer

Active Not Recruiting
NCT04929223Phase 1

A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)

Recruiting
NCT04524871Phase 1

A Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatment Combinations in Patients With Advanced Liver Cancers (Morpheus-Liver)

Recruiting
NCT05009069Phase 2

A Study of Atezolizumab With or Without Tiragolumab Following Neoadjuvant Chemoradiotherapy in Participants With Locally Advanced Rectal Cancer

Active Not Recruiting
NCT04543617Phase 3

A Study of Atezolizumab With or Without Tiragolumab in Participants With Unresectable Esophageal Squamous Cell Carcinoma Whose Cancers Have Not Progressed Following Definitive Concurrent Chemoradiotherapy

Active Not Recruiting
NCT06760481Phase 1

Phase I/Ib Trial of TIraGolumab, AtEzolizumab, and RadScopal Radiation in Patients With Advanced Solid Malignancies (TIGER)

Active Not Recruiting
NCT05251948Phase 1

An Umbrella Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Gastric or Gastroesophageal Junction Carcinoma

Terminated
NCT05286801Phase 1

Tiragolumab and Atezolizumab for the Treatment of Relapsed or Refractory SMARCB1 or SMARCA4 Deficient Tumors

Active Not Recruiting
NCT05862285Phase 3

A Rollover Study for Participants Previously Enrolled in a Genentech and/or F. Hoffman-La Roche Sponsored Study

Recruiting
NCT04540211Phase 3

A Study of Atezolizumab Plus Tiragolumab in Combination With Paclitaxel and Cisplatin Compared With Paclitaxel and Cisplatin as First-Line Treatment in Participants With Unresectable Locally Advanced, Unresectable Recurrent, or Metastatic Esophageal Carcinoma

Completed
NCT04486352Phase 1

A Study of Targeted Agents for Patients With Recurrent or Persistent Endometrial Cancer

Recruiting
NCT04300647Phase 2

A Study of Tiragolumab Plus Atezolizumab and Atezolizumab Monotherapy in Participants With Metastatic and/or Recurrent PD-L1-Positive Cervical Cancer

Completed
NCT04832854Phase 2

A Study Evaluating the Safety and Efficacy of Neoadjuvant and Adjuvant Tiragolumab Plus Atezolizumab, With or Without Platinum-Based Chemotherapy, in Participants With Previously Untreated Locally Advanced Resectable Stage II, IIIA, or Select IIIB Non-Small Cell Lung Cancer

Terminated
NCT06603818Phase 2

Immunotherapies in Combination With Stereotactic Body Radiation Radiotherapy in Microsatellite Stable (MSS) Metastatic Colorectal Cancer (mCRC)

Withdrawn

Drug Details

Intervention Type
DRUG
Total Trials
59