Success Metrics

Clinical Success Rate
58.6%

Based on 17 completed trials

Completion Rate
59%(17/29)
Active Trials
24(41%)
Results Posted
135%(23 trials)
Terminated
12(20%)

Phase Distribution

Ph phase_2
30
51%
Ph phase_3
9
15%
Ph phase_1
20
34%

Phase Distribution

20

Early Stage

30

Mid Stage

9

Late Stage

Phase Distribution59 total trials
Phase 1Safety & dosage
20(33.9%)
Phase 2Efficacy & side effects
30(50.8%)
Phase 3Large-scale testing
9(15.3%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

51.5%

17 of 33 finished

Non-Completion Rate

48.5%

16 ended early

Currently Active

24

trials recruiting

Total Trials

59

all time

Status Distribution
Active(24)
Completed(17)
Terminated(16)
Other(2)

Detailed Status

Completed17
Active, not recruiting17
Terminated12
Recruiting7
Withdrawn4
unknown2

Development Timeline

Analytics

Development Status

Total Trials
59
Active
24
Success Rate
58.6%
Most Advanced
Phase 3

Trials by Phase

Phase 120 (33.9%)
Phase 230 (50.8%)
Phase 39 (15.3%)

Trials by Status

completed1729%
active_not_recruiting1729%
unknown23%
terminated1220%
recruiting712%
withdrawn47%

Recent Activity

Clinical Trials (59)

Showing 20 of 59 trialsScroll for more
NCT03708224Phase 2

Preoperative Immunotherapy in Patients With Squamous Cell Carcinoma of the Head and Neck

Active Not Recruiting
NCT05862285Phase 3

A Rollover Study for Participants Previously Enrolled in a Genentech and/or F. Hoffman-La Roche Sponsored Study

Recruiting
NCT05805501Phase 2

A Study of Immune Checkpoint Inhibitor Combinations With Axitinib in Participants With Untreated Locally Advanced Unresectable or Metastatic Renal Cell Carcinoma

Active Not Recruiting
NCT03281369Phase 1

A Study of Multiple Immunotherapy-Based Treatment Combinations in Patients With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Cancer (G/GEJ) or Esophageal Cancer (Morpheus-Gastric and Esophageal Cancer)

Terminated
NCT03869190Phase 1

Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatments and Combinations in Patients With Urothelial Carcinoma (MORPHEUS-UC)

Terminated
NCT03784326Phase 2

Phase I/II Study of Perioperative Chemotherapy Plus Immunotherapy Followed by Surgery in Localized Esophageal and Gastroesophageal Adenocarcinoma

Active Not Recruiting
NCT05009069Phase 2

A Study of Atezolizumab With or Without Tiragolumab Following Neoadjuvant Chemoradiotherapy in Participants With Locally Advanced Rectal Cancer

Active Not Recruiting
NCT05645692Phase 2

A Study Evaluating Different Immunotherapies (LAG-3 and PD-1 With or Without TIGIT, Compared to PD-L1 Alone) in Participants With Untreated Locally Advanced Metastatic Urothelial Cancer

Active Not Recruiting
NCT04543617Phase 3

A Study of Atezolizumab With or Without Tiragolumab in Participants With Unresectable Esophageal Squamous Cell Carcinoma Whose Cancers Have Not Progressed Following Definitive Concurrent Chemoradiotherapy

Active Not Recruiting
NCT04929223Phase 1

A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)

Recruiting
NCT04524871Phase 1

A Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatment Combinations in Patients With Advanced Liver Cancers (Morpheus-Liver)

Recruiting
NCT05286801Phase 1

Tiragolumab and Atezolizumab for the Treatment of Relapsed or Refractory SMARCB1 or SMARCA4 Deficient Tumors

Active Not Recruiting
NCT05825625Phase 2

NeoTRACK - Dissection of IO Efficacy in NSCLC by Longitudinal tracKing

Active Not Recruiting
NCT06267001Phase 3

A Study of Tiragolumab Plus Atezolizumab Compared With Placebo Plus Atezolizumab in Participants With Completely Resected Non-small Cell Lung Cancer Who Have Received Adjuvant Platinum-based Chemotherapy

Terminated
NCT05798663Phase 2

Atezolizumab Immunotherapy With or Without Tiragolumab for Patients With Unresectable Stage III NSCLC

Active Not Recruiting
NCT04513925Phase 3

A Study of Atezolizumab and Tiragolumab Compared With Durvalumab in Participants With Locally Advanced, Unresectable Stage III Non-Small Cell Lung Cancer (NSCLC)

Completed
NCT04619797Phase 2

A Study of Tiragolumab in Combination With Atezolizumab Plus Pemetrexed and Carboplatin/Cisplatin Versus Pembrolizumab Plus Pemetrexed and Carboplatin/Cisplatin in Participants With Previously Untreated Advanced Non-Squamous Non-Small Cell Lung Cancer

Completed
NCT05681039Phase 2

Phase 2 Trial of Neoadjuvant and Adjuvant Tiragolumab Plus Atezolizumab in Patients With Newly Diagnosed PD-L1 CPS Positive Resectable Stage 3-4 Oral Cavity Squamous Cell Carcinoma (OCSCC).

Active Not Recruiting
NCT03337698Phase 1

A Study Of Multiple Immunotherapy-Based Treatment Combinations In Participants With Metastatic Non-Small Cell Lung Cancer (Morpheus- Non-Small Cell Lung Cancer)

Terminated
NCT05394337Phase 1

Neoadjuvant PD-1 Plus TIGIT Blockade in Patients With Cisplatin-Ineligible Operable High-Risk Urothelial Carcinoma

Recruiting

Drug Details

Intervention Type
BIOLOGICAL
Total Trials
59