Success Metrics

Clinical Success Rate
89.3%

Based on 25 completed trials

Completion Rate
89%(25/28)
Active Trials
0(0%)
Results Posted
40%(10 trials)
Terminated
3(9%)

Phase Distribution

Ph phase_4
1
3%
Ph phase_1
15
47%
Ph phase_2
4
13%
Ph phase_3
5
16%

Phase Distribution

15

Early Stage

4

Mid Stage

6

Late Stage

Phase Distribution25 total trials
Phase 1Safety & dosage
15(60.0%)
Phase 2Efficacy & side effects
4(16.0%)
Phase 3Large-scale testing
5(20.0%)
Phase 4Post-market surveillance
1(4.0%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

86.2%

25 of 29 finished

Non-Completion Rate

13.8%

4 ended early

Currently Active

0

trials recruiting

Total Trials

32

all time

Status Distribution
Completed(25)
Terminated(4)
Other(3)

Detailed Status

Completed25
Terminated3
unknown3
Withdrawn1

Development Timeline

Analytics

Development Status

Total Trials
32
Active
0
Success Rate
89.3%
Most Advanced
Phase 4

Trials by Phase

Phase 115 (60.0%)
Phase 24 (16.0%)
Phase 35 (20.0%)
Phase 41 (4.0%)

Trials by Status

completed2578%
terminated39%
unknown39%
withdrawn13%

Recent Activity

Clinical Trials (32)

Showing 20 of 32 trialsScroll for more
NCT02259855Phase 1

Pharmacokinetics (PK) of Tipranavir/Ritonavir, Ribavirin, Pegylated Interferon (Peg INF) in Hepatitis C (HCV) Subjects With Mild Hepatic Impairment and in HCV, Hepatitis B (HBV), Hepatitis D Infected Subjects or Alcoholic Cirrhosis With Moderate Hepatic Impairment

Completed
NCT00275444Phase 2

3 TPV/RTV Doses in Multiple ARV Experienced Patients - Tipranavir Dose Defining Study

Completed
NCT00056641Phase 2

Dual Boosted - Protease Inhibitor (PI) Pharmacokinetics (PK) Trial (Tipranavir / Ritonavir) in Highly Treatment-experienced HIV-1 Infected Patients

Completed
NCT00537394Phase 3

Optimizing Treatment for Treatment-Experienced, HIV-Infected People

Completed
NCT00805857

Surveillance Cohort Long-term Toxicity Antiretrovirals in HIV-infected Patients Enrolled in TPV Cohort

Withdrawn
NCT00097799

Tipranavir Expanded Access Program (EAP) in PI-experienced Patients With HIV-1 Infection

Unknown
NCT00933205

An Open Label Safety Study of Tipranavir Co-administered With Low-dose Ritonavir in Patients With Advanced HIV-1 Infection and Limited Treatment Options.

Unknown
NCT00062660

Tipranavir in Patients With Progressive, Systemic HIV-1 Disease Who Have Failed or Are Intolerant to Currently Approved Treatments for HIV Infection

Unknown
NCT02257021Phase 1

Pharmacokinetic Interaction Between Tipranavir and BILR 355 BS Plus Ritonavir in Healthy Male Volunteers

Completed
NCT02253849Phase 1

Effects of TPV/r on the Pharmacokinetics of Carbamazepine in Healthy Adult Volunteers

Completed
NCT02253862Phase 1

Pharmacokinetic of Tadalafil Co-administered With Tipranavir/Ritonavir to Healthy Male Volunteers

Completed
NCT02253797Phase 1

Pharmacokinetics of Tipranavir/Ritonavir and Its Metabolites in Healthy Male Subjects

Completed
NCT02253836Phase 1

Pharmacokinetic Study in Healthy Adult Volunteers to Assess the Interactions Between Steady-State Tipranavir and Atazanavir in the Presence of Ritonavir

Completed
NCT02251119Phase 1

The Pharmacodynamic/Pharmacokinetic Interaction of Tipranavir and Ritonavir With Loperamide in Healthy Volunteers

Completed
NCT02251171Phase 1

Effects of Steady-state TPV/RTV on the Single-dose Pharmacokinetics of Rifabutin and the Effects of Single-dose Rifabutin on the Steady-state Pharmacokinetics of TPV in Healthy Adult Volunteers

Completed
NCT02251795Phase 1

Effects of Steady State Tipranavir/Ritonavir or Darunavir/Ritonavir or Ritonavir on Platelet Function, Coagulation and Fibrinolysis Biomarkers in Healthy Subjects

Completed
NCT02251769Phase 1

Effects of Single-dose and Steady-state TPV/r on the Steady-state Pharmacokinetics of Clarithromycin and a Preliminary Assessment of the Effects of a Standard High-fat Test Meal on the Steady-state Pharmacokinetics of Tipranavir

Completed
NCT02245451Phase 1

Study of Tipranavir and Ritonavir on the Pharmacokinetic Characteristics of Methadone Administered in Healthy Volunteers

Completed
NCT02244190Phase 1

Bioequivalence of Two Different Oral Solutions Tipranavir Administered in Combination With Ritonavir to Healthy Volunteers

Completed
NCT02245269Phase 1

Pharmacokinetics of Atorvastatin With Tipranavir/Ritonavir and the Effect of Antacid on the Pharmacokinetics of Single-Dose Tipranavir/Ritonavir in Healthy Volunteers

Completed

Drug Details

Intervention Type
DRUG
Total Trials
32