Success Metrics

Clinical Success Rate
70.0%

Based on 7 completed trials

Completion Rate
70%(7/10)
Active Trials
0(0%)
Results Posted
100%(7 trials)
Terminated
3(20%)

Phase Distribution

Ph phase_1
9
60%
Ph phase_2
4
27%
Ph phase_3
1
7%

Phase Distribution

9

Early Stage

4

Mid Stage

1

Late Stage

Phase Distribution14 total trials
Phase 1Safety & dosage
9(64.3%)
Phase 2Efficacy & side effects
4(28.6%)
Phase 3Large-scale testing
1(7.1%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

63.6%

7 of 11 finished

Non-Completion Rate

36.4%

4 ended early

Currently Active

0

trials recruiting

Total Trials

15

all time

Status Distribution
Completed(7)
Terminated(4)
Other(4)

Detailed Status

Completed7
unknown4
Terminated3
Withdrawn1

Development Timeline

Analytics

Development Status

Total Trials
15
Active
0
Success Rate
70.0%
Most Advanced
Phase 3

Trials by Phase

Phase 19 (64.3%)
Phase 24 (28.6%)
Phase 31 (7.1%)

Trials by Status

unknown427%
completed747%
withdrawn17%
terminated320%

Recent Activity

Clinical Trials (15)

Showing 15 of 15 trials
NCT00742963Phase 1

Dose-Escalation Study of TH-302 in Combination With Doxorubicin to Treat Patients With Advanced Soft Tissue Sarcoma

Completed
NCT01746979Phase 3

Clinical Trial Testing TH-302 in Combination With Gemcitabine in Previously Untreated Subjects With Metastatic or Locally Advanced Unresectable Pancreatic Adenocarcinoma

Completed
NCT02047500Phase 1

Phase I TH-302 Plus Gemcitabine Plus Nab-Paclitaxel in Pancreatic Cancer

Terminated
NCT01144455Phase 2

Study of the Safety and Efficacy of TH-302 in Combination With Gemcitabine Compared With Gemcitabine Alone in Previously Untreated Patients With Pancreatic Adenocarcinoma

Completed
NCT01864538Phase 2

A Phase 2 Biomarker - Enriched Study of TH-302 in Subjects With Advanced Melanoma

Terminated
NCT02342379Phase 2

TH-302 in Combination With Bevacizumab for Glioblastoma

Completed
NCT02255110Phase 2

A Japanese Trial of TH-302 in Subjects With Locally Advanced Unresectable or Metastatic Soft Tissue Sarcoma

Terminated
NCT02712567

SARC021C: A Continuation Study of TH-CR-406/SARC021

Unknown
NCT02020226Phase 1

A Cardiac Safety Study of TH-302 in Patients With Advanced Solid Tumors

Unknown
NCT01522872Phase 1

Open-label Study of TH-302 and Dexamethasone With or Without Bortezomib or Pomalidomide in Subjects With Relapsed/Refractory Multiple Myeloma

Unknown
NCT02598687Phase 1

Testing TH-302, in Combination With Preoperative Chemoradiotherapy, in Esophageal Cancer.

Withdrawn
NCT01149915Phase 1

Study of Hypoxia-Activated Prodrug TH-302 to Treat Advanced Leukemias

Completed
NCT00743379Phase 1

Dose-Escalation Study of TH-302 in Combination With A) Gemcitabine or B) Docetaxel or C) Pemetrexed to Treat Advanced Solid Tumors

Completed
NCT01381822Phase 1

Dose-Escalation Study of TH-302 in Combination With Sunitinib to Treat Patients With Advanced Renal Cell Carcinoma,Gastrointestinal Stromal Tumors and Pancreatic Neuroendocrine Tumors

Unknown
NCT00495144Phase 1

A Phase I Study of the Safety, Pharmacokinetics, and Anti-Tumor Activity of TH-302 in Patients With Advanced Solid Tumors

Completed

All 15 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
15