Success Metrics

Clinical Success Rate
72.7%

Based on 8 completed trials

Completion Rate
73%(8/11)
Active Trials
20(56%)
Results Posted
100%(8 trials)
Terminated
3(8%)

Phase Distribution

Ph phase_2
18
50%
Ph phase_1
17
47%
Ph phase_3
1
3%

Phase Distribution

17

Early Stage

18

Mid Stage

1

Late Stage

Phase Distribution36 total trials
Phase 1Safety & dosage
17(47.2%)
Phase 2Efficacy & side effects
18(50.0%)
Phase 3Large-scale testing
1(2.8%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

72.7%

8 of 11 finished

Non-Completion Rate

27.3%

3 ended early

Currently Active

20

trials recruiting

Total Trials

36

all time

Status Distribution
Active(25)
Completed(8)
Terminated(3)

Detailed Status

Recruiting13
Completed8
Active, not recruiting7
Not yet recruiting5
Terminated3

Development Timeline

Analytics

Development Status

Total Trials
36
Active
20
Success Rate
72.7%
Most Advanced
Phase 3

Trials by Phase

Phase 117 (47.2%)
Phase 218 (50.0%)
Phase 31 (2.8%)

Trials by Status

recruiting1336%
active_not_recruiting719%
not_yet_recruiting514%
terminated38%
completed822%

Recent Activity

Clinical Trials (36)

Showing 20 of 36 trialsScroll for more
NCT07326566Phase 2

Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

Recruiting
NCT06721689Phase 1

PEEL-224, Vincristine and Temozolomide in Pediatric Solid Tumors

Recruiting
NCT06478212Phase 1

Vorasidenib in Combination With Temozolomide (TMZ) in IDH-mutant Glioma

Active Not Recruiting
NCT05417594Phase 1

Study of AZD9574 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Advanced Solid Malignancies

Recruiting
NCT04457284Phase 2

Temozolomide, Cisplatin, and Nivolumab in People With Colorectal Cancer

Completed
NCT07346157Phase 1

Liothyronine in Combination With BIT Regimen for Medulloblastoma With or Without Minimal Residual Disease

Not Yet Recruiting
NCT05843253Phase 2

Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

Recruiting
NCT07243470Phase 1

Combination of Tarlatamab and Temozolomide in Patients With Central Nervous System Tumors

Recruiting
NCT07605364Phase 2

Testing the Addition of an Anti-Cancer Drug, Mycophenolate Mofetil, to the Usual Treatment (Radiation Therapy and Temozolomide) for Advanced Brain Cancer

Not Yet Recruiting
NCT07599371Phase 1

A Prospective, Single-arm Clinical Study on the Safety and Efficacy of Ivoximab Combined With Temozolomide in the Treatment of Relapsed/Refractory Glioma

Recruiting
NCT07562971Phase 1

Focused Ultrasound Blood-Brain Barrier Opening in Pontine Diffuse Midline Glioma to Enhance Temozolomide Therapy: Pilot Feasibility Study (FIDES)

Not Yet Recruiting
NCT03749187Phase 1

BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas

Active Not Recruiting
NCT02942264Phase 1

Zotiraciclib (TG02) Plus Dose-Dense or Metronomic Temozolomide Followed by Randomized Phase II Trial of Zotiraciclib (TG02) Plus Temozolomide Versus Temozolomide Alone in Adults With Recurrent Anaplastic Astrocytoma and Glioblastoma

Terminated
NCT01356290Phase 2

Antiangiogenic Therapy for Children With Recurrent Medulloblastoma, Ependymoma, ATRT and Rare CNS Tumors

Recruiting
NCT03405792Phase 2

Study Testing The Safety and Efficacy of Adjuvant Temozolomide Plus TTFields (Optune®) Plus Pembrolizumab in Patients With Newly Diagnosed Glioblastoma (2-THE-TOP)

Active Not Recruiting
NCT07389278Phase 1

Combination ADI-PEG 20, TMZ, and RT for Treatment of Newly Diagnosed High-grade Glioma (HGG)

Not Yet Recruiting
NCT06208657Phase 1

Optimal Precision TherapIes to CustoMISE Care in Childhood and Adolescent Cancer

Recruiting
NCT04752813Phase 2

A Study of BPM31510 With Vitamin K1 in Subjects With Newly Diagnosed Glioblastoma (GB)

Active Not Recruiting
NCT07365280Phase 2

Neoantigen-Pulsed Autologous Dendritic Cell Vaccine Combined With Temozolomide for Newly Diagnosed Glioblastoma

Not Yet Recruiting
NCT07334301Phase 1

A Multi-Arm, Platform Trial For Relapsed Neuroblastoma

Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
36