Success Metrics

Clinical Success Rate
78.6%

Based on 11 completed trials

Completion Rate
79%(11/14)
Active Trials
11(39%)
Results Posted
82%(9 trials)
Terminated
3(11%)

Phase Distribution

Ph phase_2
12
43%
Ph phase_1
9
32%
Ph phase_3
7
25%

Phase Distribution

9

Early Stage

12

Mid Stage

7

Late Stage

Phase Distribution28 total trials
Phase 1Safety & dosage
9(32.1%)
Phase 2Efficacy & side effects
12(42.9%)
Phase 3Large-scale testing
7(25.0%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

78.6%

11 of 14 finished

Non-Completion Rate

21.4%

3 ended early

Currently Active

11

trials recruiting

Total Trials

28

all time

Status Distribution
Active(12)
Completed(11)
Terminated(3)
Other(2)

Detailed Status

Completed11
Active, not recruiting8
Recruiting3
Terminated3
unknown2
Not yet recruiting1

Development Timeline

Analytics

Development Status

Total Trials
28
Active
11
Success Rate
78.6%
Most Advanced
Phase 3

Trials by Phase

Phase 19 (32.1%)
Phase 212 (42.9%)
Phase 37 (25.0%)

Trials by Status

recruiting311%
unknown27%
completed1139%
active_not_recruiting829%
not_yet_recruiting14%
terminated311%

Recent Activity

Clinical Trials (28)

Showing 20 of 28 trialsScroll for more
NCT03587740Phase 2

ATOP TRIAL: T-DM1 in HER2 Positive Breast Cancer

Active Not Recruiting
NCT02326974Phase 2

T-DM1+Pertuzumab in Pre-OP Early-Stage HER2+ BRCA

Active Not Recruiting
NCT03975647Phase 3

A Study of Tucatinib vs. Placebo in Combination With Ado-trastuzumab Emtansine (T-DM1) for Patients With Advanced or Metastatic HER2+ Breast Cancer

Active Not Recruiting
NCT06830889Phase 3

A Study of BL-M07D1 Versus T-DM1 in the Adjuvant Treatment of HER2-positive Breast Cancer With Residual Invasive Cancer After Neoadjuvant Therapy

Recruiting
NCT06265428Phase 3

A Study to Compare DB-1303/BNT323 Versus T-DM1 in Breast Cancer

Active Not Recruiting
NCT06316531Phase 3

A Study Comparing BL-M07D1 With T-DM1 in Patients With Unresectable Locally Advanced or Metastatic HER2-positive Breast Cancer

Active Not Recruiting
NCT06439693Phase 2

The SAPPHO Study: Sequential Therapy With Curative Intent in de Novo HER2+ Metastatic Breast Cancer

Recruiting
NCT06968585Phase 3

A Study of A166 Versus Trastuzumab Emtansine (T-DM1) in Patients With HER2-Positive Unresectable or Metastatic Breast Cancer Previously Treated With Trastuzumab and Taxane Therapy

Active Not Recruiting
NCT04622319Phase 3

A Study of Trastuzumab Deruxtecan (T-DXd) Versus Trastuzumab Emtansine (T-DM1) in High-risk HER2-positive Participants With Residual Invasive Breast Cancer Following Neoadjuvant Therapy (DESTINY-Breast05)

Active Not Recruiting
NCT05288777Phase 2

Adjuvant Chemoradiation and Biomarkers of Response in High-risk Breast Cancer

Recruiting
NCT01565200Phase 2

HER2 Imaging Study to Identify HER2 Positive Metastatic Breast Cancer Patient Unlikely to Benefit From T-DM1

Completed
NCT01745965Phase 2

A Prospective, Randomized Multicenter, Open-label Comparison of Preoperative Trastuzumab Emtansine (T-DM1) With or Without Standard Endocrine Therapy vs. Trastuzumab With Standard Endocrine Therapy Given for Twelve Weeks in Patients With Operable HER2+/HR+ Breast Cancer Within the ADAPT Protocol.

Completed
NCT03032107Phase 1

A Study Of Pembrolizumab In Combination With Trastuzumab-DM1

Completed
NCT03530696Phase 2

T-DM1 and Palbociclib for Metastatic HER2 Breast Cancer

Completed
NCT03709082Phase 1

Palbociclib in Estrogen Receptor Positive (ER+) Human Epidermal Growth Factor Receptor 2 Positive (HER2+) Metastatic Breast Cancer

Terminated
NCT03190967Phase 1

T-DM1 Alone Versus T-DM1 and Metronomic Temozolomide in Secondary Prevention of HER2-Positive Breast Cancer Brain Metastases Following Stereotactic Radiosurgery

Terminated
NCT02236000Phase 1

A Dose-Escalation Study Evaluating the Combination of Trastuzumab Emtansine (T-DM1) With Neratinib in Women With Metastatic HER2-Positive Breast Cancer

Completed
NCT02657343Phase 1

An Open-Label, Phase Ib/II Clinical Trial Of Cdk 4/6 Inhibitor, Ribociclib (Lee011), In Combination With Trastuzumab Or T-Dm1 For Advanced/Metastatic Her2-Positive Breast Cancer.

Completed
NCT05429684Phase 3

Precise Therapy for Refractory HER2 Positive Advanced Breast Cancer

Unknown
NCT04398914Phase 2

Pyrotinib, Trastuzumab, Pertuzumab and Nab-paclitaxel as Neoadjuvant Therapy in HER2-positive Breast Cancer

Active Not Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
28