Success Metrics

Clinical Success Rate
100.0%

Based on 2 completed trials

Completion Rate
100%(2/2)
Active Trials
26(81%)
Results Posted
200%(4 trials)

Phase Distribution

Ph phase_3
6
19%
Ph phase_1
12
38%
Ph phase_2
13
41%

Phase Distribution

12

Early Stage

13

Mid Stage

6

Late Stage

Phase Distribution31 total trials
Phase 1Safety & dosage
12(38.7%)
Phase 2Efficacy & side effects
13(41.9%)
Phase 3Large-scale testing
6(19.4%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

66.7%

2 of 3 finished

Non-Completion Rate

33.3%

1 ended early

Currently Active

26

trials recruiting

Total Trials

32

all time

Status Distribution
Active(28)
Completed(2)
Terminated(1)
Other(1)

Detailed Status

Recruiting16
Active, not recruiting10
Not yet recruiting2
Completed2
Withdrawn1
unknown1

Development Timeline

Analytics

Development Status

Total Trials
32
Active
26
Success Rate
100.0%
Most Advanced
Phase 3

Trials by Phase

Phase 112 (38.7%)
Phase 213 (41.9%)
Phase 36 (19.4%)

Trials by Status

withdrawn13%
active_not_recruiting1031%
not_yet_recruiting26%
recruiting1650%
unknown13%
completed26%

Recent Activity

Clinical Trials (32)

Showing 20 of 32 trialsScroll for more
NCT07531095Phase 1

Study of Tarlatamab + ZL-1310 +/- Anti-programmed Death Ligand 1 (Anti-PD-L1) in Small Cell Lung Cancer (SCLC)

Recruiting
NCT07016230Phase 2

Study Investigating Tarlatamab (AMG 757) in Patients With Metastatic/Locally Advanced Small-Cell Lung Cancer (SCLC) and Other Poorly Differentiated Neuroendocrine Carcinomas (NECs), With Biomarker Analysis to Characterize Response/Resistance (UNLOCK TARLATAMAB)

Active Not Recruiting
NCT07402343Phase 2

Tarlatamab for SCLC Brain Metastases

Recruiting
NCT05060016Phase 2

A Phase 2 Study of Tarlatamab in Patients With Small Cell Lung Cancer (SCLC)

Active Not Recruiting
NCT06814496Phase 1

Radiation Combined With BIspecific T-Cell Engager in DLL3 Expressing Tumors

Recruiting
NCT07005128Phase 3

A Study Comparing Tarlatamab, Durvalumab, Carboplatin, and Etoposide Versus Durvalumab, Carboplatin, and Etoposide in First-line Extensive Stage Small-Cell Lung Cancer (ES-SCLC)

Recruiting
NCT07203053Phase 2

A Trial of Tarlatamab in Patients With Pretreated Extensive-stage Small Cell Lung Cancer (ES-SCLC) and ECOG PS 2

Recruiting
NCT06502977Phase 2

Study Evaluating Tarlatamab in Chinese Participants With Advanced Small Cell Lung Cancer After Two or More Prior Lines of Treatment

Active Not Recruiting
NCT07242547Phase 2

Study of Tarlatamab as Maintenance Treatment After Chemo-radiotherapy for Limited Stage SCLC Patients

Recruiting
NCT07423585Phase 2

Tarlatamab for the Treatment of Extensive Stage Small-cell Lung Cancer

Recruiting
NCT06598306Phase 1

Subcutaneous Tarlatamab in Participants With Extensive Stage Small Cell Lung Cancer (DeLLphi-308)

Recruiting
NCT07111507Phase 2

A Study of Tarlatamab for People With Prostate Cancer

Recruiting
NCT07637513Phase 3

Tarlatamab and Durvalumab vs. Durvalumab Alone for Limited-Stage-Small Cell Lung Cancer

Not Yet Recruiting
NCT07037758Phase 1

A Study of Tarlatamab in Combination With AB248 in Participants With Extensive Stage Small Cell Lung Cancer (DeLLphi-311)

Recruiting
NCT07243470Phase 1

Combination of Tarlatamab and Temozolomide in Patients With Central Nervous System Tumors

Recruiting
NCT06551142Phase 1

A Study of GSK5764227 in Participants With Advanced Solid Tumors (EMBOLD)

Recruiting
NCT06898957Phase 1

Study of Tarlatamab in Combination With YL201 With or Without Anti-programmed Death Ligand 1 (PD-L1) in Participants With Extensive Stage (ES) Small Cell Lung Cancer (SCLC)

Active Not Recruiting
NCT06117774Phase 3

Study Evaluating Tarlatamab After Chemoradiotherapy in Limited-Stage Small-Cell Lung Cancer (LS-SCLC)

Active Not Recruiting
NCT07328490Phase 1

Bispecific T-Cell Engager Tarlatamab and TROP2 Targeted Antibody Drug Conjugate Sacituzumab Govitecan in Previously Treated Extensive-Stage Small Cell Lung Cancer and Extrapulmonary Neuroendocrine Cancer

Withdrawn
NCT06893783Phase 2

Efficacy and Safety Evaluation of Tarlatamab in Advanced Extrapulmonary Neuroendocrine Carcinoma Patients

Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
32