Success Metrics

Clinical Success Rate
74.4%

Based on 32 completed trials

Completion Rate
74%(32/43)
Active Trials
29(35%)
Results Posted
100%(32 trials)
Terminated
11(13%)

Phase Distribution

Ph not_applicable
1
1%
Ph phase_2
39
46%
Ph phase_3
2
2%
Ph phase_1
38
45%

Phase Distribution

38

Early Stage

39

Mid Stage

2

Late Stage

Phase Distribution80 total trials
Phase 1Safety & dosage
38(47.5%)
Phase 2Efficacy & side effects
39(48.8%)
Phase 3Large-scale testing
2(2.5%)
N/ANon-phased studies
1(1.3%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

66.7%

32 of 48 finished

Non-Completion Rate

33.3%

16 ended early

Currently Active

29

trials recruiting

Total Trials

84

all time

Status Distribution
Active(29)
Completed(32)
Terminated(16)
Other(7)

Detailed Status

Completed32
Recruiting17
Active, not recruiting12
Terminated11
unknown6
Withdrawn5

Development Timeline

Analytics

Development Status

Total Trials
84
Active
29
Success Rate
74.4%
Most Advanced
Phase 3

Trials by Phase

Phase 138 (47.5%)
Phase 239 (48.8%)
Phase 32 (2.5%)
N/A1 (1.3%)

Trials by Status

recruiting1720%
unknown67%
withdrawn56%
terminated1113%
completed3238%
active_not_recruiting1214%
suspended11%

Recent Activity

Clinical Trials (84)

Showing 20 of 84 trialsScroll for more
NCT04550494Phase 2

Measuring the Effects of Talazoparib in Patients With Advanced Cancer and DNA Repair Variations

Active Not Recruiting
NCT05327010Phase 2

Testing the Combination of the Anti-cancer Drugs ZEN003694 (ZEN-3694) and Talazoparib in Patients With Advanced Solid Tumors, The ComBET Trial

Recruiting
NCT02912572Phase 2

Avelumab in Patients With MSS, MSI-H and POLE-mutated Recurrent or Persistent Endometrial Cancer and of Avelumab/Talazoparib and Avelumab/Axitinib in Patients With MSS Recurrent or Persistent Endometrial Cancer

Active Not Recruiting
NCT04039230Phase 1

Study to Evaluate Sacituzumab Govitecan in Combination With Talazoparib in Patients With Metastatic Breast Cancer.

Active Not Recruiting
NCT06844383Phase 2

A Study of Talazoparib With or Without Enzalutamide in People With Prostate Cancer Who Have Previously Received Abiraterone Acetate

Recruiting
NCT05059522Phase 3

Continued Access Study for Participants Deriving Benefit in Pfizer-Sponsored Avelumab Parent Studies That Are Closing

Active Not Recruiting
NCT05071937Phase 2

ZEN003694 Combined With Talazoparib in Patients With Recurrent Ovarian Cancer

Recruiting
NCT02286687Phase 2

Talazoparib in Treating Patients With Recurrent, Refractory, Advanced, or Metastatic Cancers and Alterations in the BRCA Genes

Active Not Recruiting
NCT05873192Phase 2

Presurgical Phase II Study of Talazoparib in Combination With Enzalutamide in Prostate Cancer

Recruiting
NCT04334941Phase 2

Testing Maintenance Therapy for Small Cell Lung Cancer in Patients With SLFN11 Positive Biomarker

Active Not Recruiting
NCT02693535Phase 2

TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer

Recruiting
NCT04901702Phase 1

Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma

Recruiting
NCT04846478Phase 1

Phase Ia/Ib Talazoparib + Tazemetostat for mCRPC

Active Not Recruiting
NCT03990896Phase 2

Evaluation of Talazoparib, a PARP Inhibitor, in Patients With Somatic BRCA Mutant Metastatic Breast Cancer: Genotyping Based Clinical Trial

Recruiting
NCT05101551Phase 1

Study of Talazoparib in Combination With Chemotherapy in Relapsed Pediatric AML to Determine Safety and Efficacy

Recruiting
NCT03964532Phase 1

TALAVE: Induction Talazoparib Followed by Combination of Talazoparib and Avelumab in Advanced Breast Cancer

Active Not Recruiting
NCT04486352Phase 1

A Study of Targeted Agents for Patients With Recurrent or Persistent Endometrial Cancer

Recruiting
NCT03968406Phase 1

Talazoparib and Radiation Therapy in Treating Patients With Locally Recurrent Gynecologic Cancers

Recruiting
NCT03974217Phase 1

Talazoparib for Cohesin-Mutated AML and MDS With Excess Blasts

Active Not Recruiting
NCT04734730Phase 2

Talazoparib With Androgen Deprivation Therapy and Abiraterone for the Treatment of Castration Sensitive Prostate Cancer

Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
84