Success Metrics

Clinical Success Rate
72.1%

Based on 31 completed trials

Completion Rate
72%(31/43)
Active Trials
28(34%)
Results Posted
110%(34 trials)
Terminated
12(14%)

Phase Distribution

Ph phase_1
38
46%
Ph not_applicable
1
1%
Ph phase_2
38
46%
Ph phase_3
2
2%

Phase Distribution

38

Early Stage

38

Mid Stage

2

Late Stage

Phase Distribution79 total trials
Phase 1Safety & dosage
38(48.1%)
Phase 2Efficacy & side effects
38(48.1%)
Phase 3Large-scale testing
2(2.5%)
N/ANon-phased studies
1(1.3%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

64.6%

31 of 48 finished

Non-Completion Rate

35.4%

17 ended early

Currently Active

28

trials recruiting

Total Trials

83

all time

Status Distribution
Active(28)
Completed(31)
Terminated(17)
Other(7)

Detailed Status

Completed31
Recruiting15
Active, not recruiting13
Terminated12
unknown6
Withdrawn5

Development Timeline

Analytics

Development Status

Total Trials
83
Active
28
Success Rate
72.1%
Most Advanced
Phase 3

Trials by Phase

Phase 138 (48.1%)
Phase 238 (48.1%)
Phase 32 (2.5%)
N/A1 (1.3%)

Trials by Status

withdrawn56%
terminated1214%
active_not_recruiting1316%
recruiting1518%
suspended11%
unknown67%
completed3137%

Recent Activity

Clinical Trials (83)

Showing 20 of 83 trialsScroll for more
NCT05327010Phase 2

Testing the Combination of the Anti-cancer Drugs ZEN003694 (ZEN-3694) and Talazoparib in Patients With Advanced Solid Tumors, The ComBET Trial

Active Not Recruiting
NCT03964532Phase 1

TALAVE: Induction Talazoparib Followed by Combination of Talazoparib and Avelumab in Advanced Breast Cancer

Active Not Recruiting
NCT05142241Phase 2

Testing the Combination of Anti-Cancer Drugs Talazoparib and Temozolomide in Patients With Advanced Stage Rare Cancers, RARE 2 Trial

Active Not Recruiting
NCT04019327Phase 1

A Study of the Drugs Talazoparib and Temozolomide in Prostate Cancer

Terminated
NCT06844383Phase 2

A Study of Talazoparib With or Without Enzalutamide in People With Prostate Cancer Who Have Previously Received Abiraterone Acetate or Darolutamide

Recruiting
NCT04550494Phase 2

Measuring the Effects of Talazoparib in Patients With Advanced Cancer and DNA Repair Variations

Active Not Recruiting
NCT02912572Phase 2

Avelumab in Patients With MSS, MSI-H and POLE-mutated Recurrent or Persistent Endometrial Cancer and of Avelumab/Talazoparib and Avelumab/Axitinib in Patients With MSS Recurrent or Persistent Endometrial Cancer

Active Not Recruiting
NCT04039230Phase 1

Study to Evaluate Sacituzumab Govitecan in Combination With Talazoparib in Patients With Metastatic Breast Cancer.

Active Not Recruiting
NCT05059522Phase 3

Continued Access Study for Participants Deriving Benefit in Pfizer-Sponsored Avelumab Parent Studies That Are Closing

Active Not Recruiting
NCT05071937Phase 2

ZEN003694 Combined With Talazoparib in Patients With Recurrent Ovarian Cancer

Recruiting
NCT02286687Phase 2

Talazoparib in Treating Patients With Recurrent, Refractory, Advanced, or Metastatic Cancers and Alterations in the BRCA Genes

Active Not Recruiting
NCT05873192Phase 2

Presurgical Phase II Study of Talazoparib in Combination With Enzalutamide in Prostate Cancer

Recruiting
NCT04334941Phase 2

Testing Maintenance Therapy for Small Cell Lung Cancer in Patients With SLFN11 Positive Biomarker

Active Not Recruiting
NCT04901702Phase 1

Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma

Recruiting
NCT04846478Phase 1

Phase Ia/Ib Talazoparib + Tazemetostat for mCRPC

Active Not Recruiting
NCT03990896Phase 2

Evaluation of Talazoparib, a PARP Inhibitor, in Patients With Somatic BRCA Mutant Metastatic Breast Cancer: Genotyping Based Clinical Trial

Recruiting
NCT05101551Phase 1

Study of Talazoparib in Combination With Chemotherapy in Relapsed Pediatric AML to Determine Safety and Efficacy

Recruiting
NCT04486352Phase 1

A Study of Targeted Agents for Patients With Recurrent or Persistent Endometrial Cancer

Recruiting
NCT03968406Phase 1

Talazoparib and Radiation Therapy in Treating Patients With Locally Recurrent Gynecologic Cancers

Recruiting
NCT03974217Phase 1

Talazoparib for Cohesin-Mutated AML and MDS With Excess Blasts

Active Not Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
83