Success Metrics

Clinical Success Rate
90.9%

Based on 20 completed trials

Completion Rate
91%(20/22)
Active Trials
2(8%)
Results Posted
35%(7 trials)
Terminated
2(8%)

Phase Distribution

Ph phase_2
1
4%
Ph phase_1
19
79%
Ph phase_3
4
17%

Phase Distribution

19

Early Stage

1

Mid Stage

4

Late Stage

Phase Distribution24 total trials
Phase 1Safety & dosage
19(79.2%)
Phase 2Efficacy & side effects
1(4.2%)
Phase 3Large-scale testing
4(16.7%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

90.9%

20 of 22 finished

Non-Completion Rate

9.1%

2 ended early

Currently Active

2

trials recruiting

Total Trials

24

all time

Status Distribution
Active(2)
Completed(20)
Terminated(2)

Detailed Status

Completed20
Terminated2
Active, not recruiting1
Recruiting1

Development Timeline

Analytics

Development Status

Total Trials
24
Active
2
Success Rate
90.9%
Most Advanced
Phase 3

Trials by Phase

Phase 119 (79.2%)
Phase 21 (4.2%)
Phase 34 (16.7%)

Trials by Status

completed2083%
active_not_recruiting14%
recruiting14%
terminated28%

Recent Activity

Clinical Trials (24)

Showing 20 of 24 trialsScroll for more
NCT07052903Phase 3

TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy

Recruiting
NCT04153149Phase 3

HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy

Active Not Recruiting
NCT03783377Phase 1

Study of ARO-APOC3 in Healthy Volunteers, Hypertriglyceridemic Patients and Patients With Familial Chylomicronemia Syndrome (FCS)

Completed
NCT03362242Phase 1

Study of ARO-AAT in Normal Adult Volunteers

Completed
NCT03747224Phase 1

Study of ARO-ANG3 in Healthy Volunteers and in Dyslipidemic Patients

Completed
NCT03365947Phase 1

Study of ARO-HBV in Normal Adult Volunteers and Patients With Hepatitis B Virus (HBV)

Completed
NCT04202354Phase 1

Study of ARO-HSD in Healthy Volunteers and Patients With Non-Alcoholic Steatohepatitis (NASH) or Suspected NASH

Completed
NCT04555486Phase 1

Study to Evaluate Safety, Tolerability, PK and PD of DCR-PHXC in PH Type 3 Patients

Completed
NCT03847909Phase 2

A Study to Evaluate DCR-PHXC in Children and Adults With Primary Hyperoxaluria Type 1 and Primary Hyperoxaluria Type 2

Completed
NCT01960348Phase 3

APOLLO: The Study of an Investigational Drug, Patisiran (ALN-TTR02), for the Treatment of Transthyretin (TTR)-Mediated Amyloidosis

Completed
NCT02035605Phase 1

A Phase 1 Study of an Investigational Drug, ALN-AT3SC, in Healthy Volunteers and Hemophilia A or B Patients

Completed
NCT02352493Phase 1

A Phase 1/2 Study of an Investigational Drug, ALN-CC5, in Healthy Adult Volunteers and Patients With PNH

Completed
NCT02503683Phase 1

A Study of an Investigational Drug, ALN-AAT, in Healthy Adult Subjects and Patients With ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease

Terminated
NCT02414594Phase 1

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IONIS APO(a)-LRx in Healthy Volunteers With Elevated Lipoprotein(a)

Completed
NCT02826018Phase 1

A Study of ALN-HBV in Healthy Adult Volunteers and Non-cirrhotic Patients With Chronic Hepatitis B Virus (HBV) Infection

Terminated
NCT02797847Phase 1

A Safety and Tolerability Study of an Investigational Drug, ALN-TTRSC02, in Healthy Subjects

Completed
NCT02319005Phase 3

ENDEAVOUR: Phase 3 Multicenter Study of Revusiran (ALN-TTRSC) in Patients With Transthyretin (TTR) Mediated Familial Amyloidotic Cardiomyopathy (FAC)

Completed
NCT02452372Phase 1

A Phase 1 Study of Givosiran (ALN-AS1) in Patients With Acute Intermittent Porphyria (AIP)

Completed
NCT01814839Phase 1

A Phase 1, Single- and Multi-Dose, Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneously Administered ALN-TTRSC (Revusiran) in Healthy Volunteers

Completed
NCT02314442Phase 1

A Phase 1 Study of an Investigational Drug, ALN-PCSSC, in Subjects With Elevated Low Density Lipoprotein Cholesterol (LDL-C)

Completed

Drug Details

Intervention Type
DRUG
Total Trials
24