Success Metrics

Clinical Success Rate
76.5%

Based on 13 completed trials

Completion Rate
76%(13/17)
Active Trials
7(24%)
Results Posted
100%(13 trials)
Terminated
4(14%)

Phase Distribution

Ph phase_3
5
17%
Ph phase_1
3
10%
Ph phase_4
5
17%
Ph phase_2
16
55%

Phase Distribution

3

Early Stage

16

Mid Stage

10

Late Stage

Phase Distribution29 total trials
Phase 1Safety & dosage
3(10.3%)
Phase 2Efficacy & side effects
16(55.2%)
Phase 3Large-scale testing
5(17.2%)
Phase 4Post-market surveillance
5(17.2%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

72.2%

13 of 18 finished

Non-Completion Rate

27.8%

5 ended early

Currently Active

7

trials recruiting

Total Trials

29

all time

Status Distribution
Active(11)
Completed(13)
Terminated(5)

Detailed Status

Completed13
Recruiting5
Not yet recruiting4
Terminated4
Active, not recruiting2
Withdrawn1

Development Timeline

Analytics

Development Status

Total Trials
29
Active
7
Success Rate
76.5%
Most Advanced
Phase 4

Trials by Phase

Phase 13 (10.3%)
Phase 216 (55.2%)
Phase 35 (17.2%)
Phase 45 (17.2%)

Trials by Status

not_yet_recruiting414%
recruiting517%
active_not_recruiting27%
terminated414%
completed1345%
withdrawn13%

Recent Activity

Clinical Trials (29)

Showing 20 of 29 trialsScroll for more
NCT07218029Phase 3

A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)

Recruiting
NCT06814145Phase 2

Extension Study of Sotatercept in People With Pulmonary Hypertension (MK-7962-023)

Active Not Recruiting
NCT07140484Phase 4

Sotatercept in Pulmonary Arterial Hypertension

Recruiting
NCT07600723Phase 4

A Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (PAH) in India (MK-7962-037)

Not Yet Recruiting
NCT07646860Phase 2

A Study of Sotatercept (MK-7962) in Japanese Children With Pulmonary Arterial Hypertension (PAH) (MK-7962-032)

Not Yet Recruiting
NCT05818137Phase 3

A Study of Sotatercept in Japanese Pulmonary Arterial Hypertension (PAH) Participants (MK-7962-020)

Completed
NCT04811092Phase 3

Study of Sotatercept in Newly Diagnosed Intermediate- and High-Risk PAH Participants (MK-7962-005/A011-13)

Terminated
NCT04896008Phase 3

A Study of Sotatercept in Participants With PAH WHO FC III or FC IV at High Risk of Mortality (MK-7962-006/ZENITH)

Completed
NCT05587712Phase 2

Study to Evaluate Sotatercept (MK-7962) in Children With Pulmonary Arterial Hypertension (PAH) (MK-7962-008)

Recruiting
NCT06409026Phase 4

Sotatercept on Central Cardiopulmonary Performance and Peripheral Oxygen Transport During Exercise in Pulmonary Arterial Hypertension

Completed
NCT07498803Phase 2

Sota-ES - Sotatercept in Patients With Congenital Heart Disease and Eisenmenger´s Syndrome

Not Yet Recruiting
NCT07356778Phase 4

A Study of Sotatercept for Patients With Eisenmenger Syndrome or Unrepaired Shunt-Associated Pulmonary Arterial Hypertension Resistant to Vasodilator Therapy

Recruiting
NCT06930664Phase 1

A Study of Sotatercept (MK-7962) in Healthy Females Administered as a Liquid Formulation in an Autoinjector Versus the Lyophilized Formulation (MK-7962-027)

Completed
NCT06664801Phase 2

A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (PAH) (MK-7962-024)

Completed
NCT07266519Phase 2

SIRIUS - Initial Combination Therapy With an Endothelin Receptor Antagonist, a Phosphodiesterase-5 Inhibitor and Sotatercept in Patients With Newly Diagnosed Pulmonary Arterial Hypertension

Not Yet Recruiting
NCT06925750Phase 2

A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-031/LIGHTRAY EXTENSION)

Active Not Recruiting
NCT06658522Phase 4

Right Ventricular Compensation With Sotatercept: A Prospective Single Arm Open Label Phase 4 Study to Evaluate the Effects of Sotatercept on Right Ventricular Function in Pulmonary Arterial Hypertension (RECOMPENSE)

Recruiting
NCT06843460Phase 1

A Clinical Study of MK-7962 in Healthy Chinese Participants (MK-7962-021)

Completed
NCT04576988Phase 3

A Study of Sotatercept for the Treatment of Pulmonary Arterial Hypertension (MK-7962-003/A011-11)(STELLAR)

Completed
NCT03738150Phase 2

A Study of Sotatercept for the Treatment of Pulmonary Arterial Hypertension

Completed

Drug Details

Intervention Type
BIOLOGICAL
Total Trials
29