Success Metrics

Clinical Success Rate
77.8%

Based on 14 completed trials

Completion Rate
78%(14/18)
Active Trials
1(4%)
Results Posted
43%(6 trials)
Terminated
4(17%)

Phase Distribution

Ph phase_2
8
35%
Ph early_phase_1
1
4%
Ph not_applicable
3
13%
Ph phase_4
1
4%
Ph phase_1
10
43%

Phase Distribution

11

Early Stage

8

Mid Stage

1

Late Stage

Phase Distribution23 total trials
Early Phase 1First-in-human
1(4.3%)
Phase 1Safety & dosage
10(43.5%)
Phase 2Efficacy & side effects
8(34.8%)
Phase 4Post-market surveillance
1(4.3%)
N/ANon-phased studies
3(13.0%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

73.7%

14 of 19 finished

Non-Completion Rate

26.3%

5 ended early

Currently Active

1

trials recruiting

Total Trials

23

all time

Status Distribution
Active(3)
Completed(14)
Terminated(5)
Other(1)

Detailed Status

Completed14
Terminated4
Not yet recruiting1
Enrolling by invitation1
Recruiting1
Withdrawn1

Development Timeline

Analytics

Development Status

Total Trials
23
Active
1
Success Rate
77.8%
Most Advanced
Phase 4

Trials by Phase

Early Phase 11 (4.3%)
Phase 110 (43.5%)
Phase 28 (34.8%)
Phase 41 (4.3%)
N/A3 (13.0%)

Trials by Status

not_yet_recruiting14%
terminated417%
completed1461%
enrolling_by_invitation14%
recruiting14%
withdrawn14%
suspended14%

Recent Activity

Clinical Trials (23)

Showing 20 of 23 trialsScroll for more
NCT05028803Not Applicable

The Effects of Sodium Phenylbutyrate on Circulating Branched Chain Amino Acids

Completed
NCT06645769Early Phase 1

Na-Phenylbutyrate VAscular Trial

Not Yet Recruiting
NCT06069375Phase 2

Study of Sodium Phenylbutyrate (ACER-001) for the Treatment of Patients With Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCADD)

Suspended
NCT07125066Phase 1

An Individual Patient, Open Label Study to Use ACER-001 to Treat Combined D,L-2 Hydroxyglutaric Aciduria (C-2HGA)

Enrolling By Invitation
NCT06773026Phase 2

Study of Sodium Phenylbutyrate (ACER-001) for the Treatment of Pediatric and Adults Patients With Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCADD)

Recruiting
NCT00528268Phase 1

Study to Evaluate Sodium Phenylbutyrate in Pre-symptomatic Infants With Spinal Muscular Atrophy

Completed
NCT05349435Phase 1

A Healthy Volunteer Study to Compare Fezagepras (PBI-4050) With Sodium Phenylbutyrate

Terminated
NCT03734263Phase 2

Use of Phenylbutyrate Therapy for Patients With Pyruvate Dehydrogenase Complex Deficiency.

Completed
NCT00005639Phase 1

Azacitidine Plus Phenylbutyrate in Treating Patients With Advanced or Metastatic Solid Tumors That Have Not Responded to Previous Treatment

Completed
NCT00771901Not Applicable

Effect of Endoplasmic Reticulum Stress on Metabolic Function

Completed
NCT00345605Phase 2

Arginine and Buphenyl in Patients With Argininosuccinic Aciduria (ASA), a Urea Cycle Disorder

Completed
NCT02111200Not Applicable

Comparative Efficacy of Phenylbutyrate (PBA) vs. Benzoate in Urea Cycle Disorders

Completed
NCT00006239Phase 1

Phenylbutyrate and Tretinoin in Treating Patients With Hematologic Cancer

Completed
NCT00006019Phase 2

Phenylbutyrate Plus Azacitidine in Treating Patients With Acute Myeloid Leukemia, Myelodysplasia, Non-Hodgkin's Lymphoma, Multiple Myeloma, Non-small Cell Lung Cancer, or Prostate Cancer

Completed
NCT00002796Phase 1

Phase I-II Study of Fluorouracil in Combination With Phenylbutyrate in Advanced Colorectal Cancer

Terminated
NCT01096095Phase 2

Pilot Study of Safety and Efficacy of Sodium Phenylbutyrate in Spinocerebellar Ataxia Type 3

Withdrawn
NCT00212316Phase 2

Safety and Tolerability Study of Phenylbutyrate in Huntington's Disease (PHEND-HD)

Completed
NCT00439218Phase 1

Clinical Trial of Sodium Phenylbutyrate in Children With Spinal Muscular Atrophy Type I

Terminated
NCT00439569Phase 1

Clinical Trial of Sodium Phenylbutyrate in Children With Spinal Muscular Atrophy Types II or III

Terminated
NCT00533559Phase 4

Mechanism of Fatty Acid-induced Impairment of Glucose-simulated Insulin Secretion - Effect of Buphenyl

Completed

Drug Details

Intervention Type
DRUG
Total Trials
23