Success Metrics

Clinical Success Rate
63.6%

Based on 14 completed trials

Completion Rate
64%(14/22)
Active Trials
2(7%)
Results Posted
86%(12 trials)
Terminated
8(27%)

Phase Distribution

Ph phase_1
9
30%
Ph phase_3
4
13%
Ph early_phase_1
1
3%
Ph phase_2
16
53%

Phase Distribution

10

Early Stage

16

Mid Stage

4

Late Stage

Phase Distribution30 total trials
Early Phase 1First-in-human
1(3.3%)
Phase 1Safety & dosage
9(30.0%)
Phase 2Efficacy & side effects
16(53.3%)
Phase 3Large-scale testing
4(13.3%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

56.0%

14 of 25 finished

Non-Completion Rate

44.0%

11 ended early

Currently Active

2

trials recruiting

Total Trials

30

all time

Status Distribution
Active(2)
Completed(14)
Terminated(11)
Other(3)

Detailed Status

Completed14
Terminated8
unknown3
Withdrawn3
Active, not recruiting2

Development Timeline

Analytics

Development Status

Total Trials
30
Active
2
Success Rate
63.6%
Most Advanced
Phase 3

Trials by Phase

Early Phase 11 (3.3%)
Phase 19 (30.0%)
Phase 216 (53.3%)
Phase 34 (13.3%)

Trials by Status

active_not_recruiting27%
unknown310%
terminated827%
withdrawn310%
completed1447%

Recent Activity

Clinical Trials (30)

Showing 20 of 30 trialsScroll for more
NCT02664935Phase 2

National Lung Matrix Trial: Multi-drug Phase II Trial in Non-Small Cell Lung Cancer

Completed
NCT04164199Phase 3

Study of Tislelizumab, Pamiparib, and Other Investigational Agents in Participants With Advanced Malignancies

Active Not Recruiting
NCT04904302Phase 2

Sitravatinib and Nivolumab for the Treatment of Metastatic or Advanced Clear Cell Renal Cell Cancer

Terminated
NCT03906071Phase 3

Phase 3 Study of Sitravatinib Plus Nivolumab vs Docetaxel in Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer

Completed
NCT04887870Phase 2

Study of Sitravatinib With or Without Other Anticancer Therapies Receiving Clinical Benefit From Parent Study

Completed
NCT04921358Phase 3

Tislelizumab in Combination With Sitravatinib in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Terminated
NCT05461794Phase 2

Study To Investigate the Efficacy and Safety of Sitravatinib in Combination With Tislelizumab in Participants With Esophageal Squamous Cell Carcinoma

Terminated
NCT04925986Phase 2

Sitravatinib Plus Pembrolizumab in Patients With Advanced Treatment-Naïve PD-L1+ Non-Squamous NSCLC

Terminated
NCT03015740Phase 1

Sitravatinib and Nivolumab in Treating Patients With Advanced or Metastatic Kidney Cancer

Completed
NCT03666143Phase 1

A Phase 1b Study to Assess Sitravatinib in Combination With Tislelizumab in Participants With Advanced Solid Tumors

Completed
NCT04472650Phase 1

Relative Bioavailability of Two Different Capsule Formulations of Sitravatinib in Healthy Adults

Completed
NCT03941873Phase 1

A Study to Investigate Sitravatinib as Monotherapy and in Combination With Tislelizumab in Participants With Unresectable Locally Advanced or Metastatic Hepatocellular Carcinoma or Gastric/Gastroesophageal Junction Cancer

Completed
NCT04123704Phase 2

Sitravatinib in Metastatic Breast Cancer

Terminated
NCT04518046Phase 1

Study of Sitravatinib, Nivolumab and Ipilimumab in Advanced or Metastatic Clear-Cell Renal Cell Carcinoma or Other Solid Malignancies

Completed
NCT04887194Phase 1

PK Study to Assess Drug-drug Interaction and QTc Between Sitravatinib and a Cocktail of Substrates

Completed
NCT02954991Phase 2

Phase 2 Study of Glesatinib, Sitravatinib or Mocetinostat in Combination With Nivolumab in Non-Small Cell Lung Cancer

Terminated
NCT04727996Phase 2

Phase II Study of Sitravatinib in Combination With Tislelizumab in Patients With Advanced Biliary Tract Cancer

Active Not Recruiting
NCT05176925Phase 2

Tislelizumab Combined With Sitravatinib as Consolidation Treatment Following Concurrent Chemoradiation in Patients With Locally Advanced, Unresectable NSCLC

Terminated
NCT04734262Phase 2

A Phase II Study to Explore the Safety, Tolerability, and Preliminary Antitumor Activity of Sitravatinib Plus Tislelizumab or Combination With Nab-paclitaxel in Patients With Locally Recurrent or Metastatic Triple Negative Breast Cancer (TNBC)

Unknown
NCT04772612Phase 1

A Study to Evaluate the Effect of Mild, Moderate, and Severe Hepatic Impairment on Pharmacokinetics of Sitravatinib

Completed

Drug Details

Intervention Type
DRUG
Total Trials
30