Success Metrics

Clinical Success Rate
80.0%

Based on 4 completed trials

Completion Rate
80%(4/5)
Active Trials
2(10%)
Results Posted
0%(0 trials)
Terminated
1(5%)

Phase Distribution

Ph phase_3
2
10%
Ph phase_2
8
40%
Ph phase_1
10
50%

Phase Distribution

10

Early Stage

8

Mid Stage

2

Late Stage

Phase Distribution20 total trials
Phase 1Safety & dosage
10(50.0%)
Phase 2Efficacy & side effects
8(40.0%)
Phase 3Large-scale testing
2(10.0%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

80.0%

4 of 5 finished

Non-Completion Rate

20.0%

1 ended early

Currently Active

2

trials recruiting

Total Trials

20

all time

Status Distribution
Active(2)
Completed(4)
Terminated(1)
Other(13)

Detailed Status

unknown13
Completed4
Active, not recruiting1
Recruiting1
Terminated1

Development Timeline

Analytics

Development Status

Total Trials
20
Active
2
Success Rate
80.0%
Most Advanced
Phase 3

Trials by Phase

Phase 110 (50.0%)
Phase 28 (40.0%)
Phase 32 (10.0%)

Trials by Status

unknown1365%
completed420%
active_not_recruiting15%
recruiting15%
terminated15%

Recent Activity

Clinical Trials (20)

Showing 20 of 20 trials
NCT05176080Phase 1

Famitinib Plus SHR6390 and Endocrine Therapy in the Treatment of HR-positive, HER2-negative Advanced Breast Cancer

Terminated
NCT04842617Phase 3

Phase III Study :SHR6390/Placebo Combined With Endocrine Therapy for the Adjuvant Treatment of Hormone Receptor Positive,Human Epidermal Receptor 2 Negative

Active Not Recruiting
NCT05205200Phase 2

Immune Therapy in HR-positive/HER2-negative Metastatic Breast Cancer(ENIGMA)-BCTOP-L-M02

Recruiting
NCT03481998Phase 1

A Study of SHR6390 in Combination With Letrozole or Anastrozole or Fulvestrant in Patients With HR Positive and HER2 Negative Advanced Breast Cancer

Completed
NCT04293276Phase 2

Study to Evaluate the Efficacy and Safety of SHR6390 Combined With Pyrotinib in HER2+ Advanced Breast Cancer

Unknown
NCT04733417Phase 2

A Study of SHR6390 Combined With Famitinib in the Treatment of HR + / HER2- Advanced Breast Cancer.

Unknown
NCT05515289Phase 1

Study of SHR6390 in Renal Insufficiency and Healthy Subjects

Unknown
NCT04355858Phase 2

Molecularly Targeted Umbrella Study in Luminal Advanced Breast Cancer

Unknown
NCT04301804Phase 1

A Trial of SHR6390 in Healthy Caucasian Volunteers

Completed
NCT02684266Phase 1

A Study of SHR6390 in Advanced Solid Tumor Patients

Completed
NCT05185869Phase 2

SHR6390 Plus Nab-paclitaxel and Gemcitabine in Advanced/Metastatic Pancreatic Cancer

Unknown
NCT04667156Phase 1

Study to Investigate Relative Bioavailability of Different Formulations of SHR6390 in Healthy Subjects

Completed
NCT03927456Phase 3

A Study of SHR6390 in Combination With Fulvestrant in Patients With HR Positive and HER2 Negative Advanced Breast Cancer

Unknown
NCT04866381Phase 2

An Exploratory Clinical Study of SHR6390 and SHR1020 in the Treatment of Esophageal Squamous Cell Carcinoma After Progression on PD-1 Antibody

Unknown
NCT04631575Phase 1

An Investigational Study of SHR6390 in Participants With Mild to Moderate Liver Impairment and Healthy Participants

Unknown
NCT04236310Phase 2

A Study of Neoadjuvant SHR6390 in Combination With Anastrozole, Pyrotinib, and Trastuzumab in Patients With ER+/HER2+ Breast Cancer.

Unknown
NCT04095390Phase 2

A Phase Ⅱ Trial of Pyrotinib Combination With CDK4/6 Inhibitor SHR6390 in Patients Prior Trastuzumab-treated Advanced HER2-Positive Breast Cancer

Unknown
NCT03480256Phase 1

Study to Evaluate SHR6390 Combined With Pyrotinib in Patients With HER2 Positive Gastric Cancer

Unknown
NCT03601598Phase 1

A Trial of SHR-1210 in Combination With SHR6390 in Patients With Advanced CRC, NSCLC and HCC

Unknown
NCT02671513Phase 1

A Tolerability and Pharmacokinetics Study of SHR6390 in Advanced Melanoma Patients

Unknown

All 20 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
20