Success Metrics

Clinical Success Rate
68.4%

Based on 39 completed trials

Completion Rate
68%(39/57)
Active Trials
50(36%)
Results Posted
85%(33 trials)
Terminated
18(13%)

Phase Distribution

Ph phase_2
57
41%
Ph phase_1
62
44%
Ph phase_4
1
1%
Ph phase_3
10
7%
Ph not_applicable
4
3%
Ph early_phase_1
1
1%

Phase Distribution

63

Early Stage

57

Mid Stage

11

Late Stage

Phase Distribution135 total trials
Early Phase 1First-in-human
1(0.7%)
Phase 1Safety & dosage
62(45.9%)
Phase 2Efficacy & side effects
57(42.2%)
Phase 3Large-scale testing
10(7.4%)
Phase 4Post-market surveillance
1(0.7%)
N/ANon-phased studies
4(3.0%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

56.5%

39 of 69 finished

Non-Completion Rate

43.5%

30 ended early

Currently Active

50

trials recruiting

Total Trials

140

all time

Status Distribution
Active(58)
Completed(39)
Terminated(30)
Other(13)

Detailed Status

Completed39
Recruiting30
Active, not recruiting20
Terminated18
unknown13
Withdrawn12

Development Timeline

Analytics

Development Status

Total Trials
140
Active
50
Success Rate
68.4%
Most Advanced
Phase 4

Trials by Phase

Early Phase 11 (0.7%)
Phase 162 (45.9%)
Phase 257 (42.2%)
Phase 310 (7.4%)
Phase 41 (0.7%)
N/A4 (3.0%)

Trials by Status

recruiting3021%
unknown139%
completed3928%
withdrawn129%
terminated1813%
active_not_recruiting2014%
not_yet_recruiting86%

Recent Activity

Clinical Trials (140)

Showing 20 of 140 trialsScroll for more
NCT05333458Phase 2

Testing Atezolizumab With Selinexor in People ≥ 12 Years Old With Alveolar Soft Part Sarcoma, AXIOM Trial

Recruiting
NCT05099003Phase 1

A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

Recruiting
NCT06158841Phase 3

Study Assessing Activity of Intravenous (IV) Etentamig Monotherapy Versus Standard Available Therapies in Adult Participants With Relapsed or Refractory Multiple Myeloma

Recruiting
NCT05432804Phase 1

Testing the Addition of an Anti-cancer Drug, Selinexor, to the Usual Chemotherapy Treatment (Temozolomide) for Brain Tumors That Have Returned After Previous Treatment

Recruiting
NCT02343042Phase 1

Selinexor and Backbone Treatments of Multiple Myeloma Patients

Recruiting
NCT06169215Phase 2

Comparing the Combination of Selinexor-Daratumumab-Velcade-Dexamethasone (Dara-SVD) With the Usual Treatment (Dara-RVD) for High-Risk Newly Diagnosed Multiple Myeloma

Active Not Recruiting
NCT06239272Phase 1

NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)

Recruiting
NCT02227251Phase 2

Selinexor (KPT-330) in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)

Active Not Recruiting
NCT04562870Phase 2

A Study to Evaluate Single Agent Selinexor Versus Physician's Choice in Participants With Previously Treated Myelofibrosis

Active Not Recruiting
NCT06813079Phase 2

Using Tumor Models to Determine Treatments

Recruiting
NCT02835222Phase 2

Selinexor With Combination With Induction/Consolidation Therapy in Acute Myeloid Leukemia Patients

Active Not Recruiting
NCT07632170Not Applicable

The Efficacy and Safety of Selinisole Combined With Azacitidine and Venetoclax in the Treatment of Newly Diagnosed High-risk Myeloid Tumors With TP53 Mutations

Not Yet Recruiting
NCT03627403Phase 2

Selinexor in Myelofibrosis Refractory or Intolerant to JAK1/2 Inhibitors

Terminated
NCT07200102Phase 1

Selinexor Maintenance Post CAR-T Cell Therapy for Multiple Myeloma

Recruiting
NCT07626021Phase 2

Selinexor Monotherapy for Cytoreduction in BCR::ABL1-Negative Myeloproliferative Neoplasms

Not Yet Recruiting
NCT05322330Phase 2

Clinical Study of XPO-1 Inhibitors Plus CAR-T Cells in Relapsed Refractory B-cell Non-Hodgkin's Lymphoma

Completed
NCT05611931Phase 3

Selinexor in Maintenance Therapy After Systemic Therapy for Participants With p53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma

Active Not Recruiting
NCT04640779Phase 1

Low-Dose Selinexor and Choline Salicylate for Non-Hodgkin or Hodgkin Lymphoma, Histiocytic/Dendritic Cell Neoplasm, or Relapsed or Refractory Multiple Myeloma

Completed
NCT07138209Phase 3

A Study Comparing QLS32015 Monotherapy Versus Pomalidomide, Dexamethasone (Pd) or Selinexor, Dexamethasone (Sd) in Participants With Relapsed or Refractory Multiple Myeloma

Recruiting
NCT07479979Phase 1

Study of Selinexor With Carfilzomib, Isatuximab and Dexamethasone for Patients With Relapsed and/or Refractory Multiple Myeloma

Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
140