Success Metrics

Clinical Success Rate
67.3%

Based on 37 completed trials

Completion Rate
67%(37/55)
Active Trials
49(36%)
Results Posted
89%(33 trials)
Terminated
18(13%)

Phase Distribution

Ph not_applicable
3
2%
Ph phase_1
62
45%
Ph phase_2
55
40%
Ph phase_3
10
7%
Ph phase_4
1
1%
Ph early_phase_1
1
1%

Phase Distribution

63

Early Stage

55

Mid Stage

11

Late Stage

Phase Distribution132 total trials
Early Phase 1First-in-human
1(0.8%)
Phase 1Safety & dosage
62(47.0%)
Phase 2Efficacy & side effects
55(41.7%)
Phase 3Large-scale testing
10(7.6%)
Phase 4Post-market surveillance
1(0.8%)
N/ANon-phased studies
3(2.3%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

55.2%

37 of 67 finished

Non-Completion Rate

44.8%

30 ended early

Currently Active

49

trials recruiting

Total Trials

137

all time

Status Distribution
Active(56)
Completed(37)
Terminated(30)
Other(14)

Detailed Status

Completed37
Recruiting28
Active, not recruiting21
Terminated18
unknown14
Withdrawn12

Development Timeline

Analytics

Development Status

Total Trials
137
Active
49
Success Rate
67.3%
Most Advanced
Phase 4

Trials by Phase

Early Phase 11 (0.8%)
Phase 162 (47.0%)
Phase 255 (41.7%)
Phase 310 (7.6%)
Phase 41 (0.8%)
N/A3 (2.3%)

Trials by Status

unknown1410%
withdrawn129%
not_yet_recruiting75%
active_not_recruiting2115%
recruiting2820%
completed3727%
terminated1813%

Recent Activity

Clinical Trials (137)

Showing 20 of 137 trialsScroll for more
NCT05099003Phase 1

A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

Recruiting
NCT02227251Phase 2

Selinexor (KPT-330) in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)

Active Not Recruiting
NCT05985161Phase 2

A Study of Selinexor in People With Wilms Tumors and Other Solid Tumors

Recruiting
NCT05432804Phase 1

Testing the Addition of an Anti-cancer Drug, Selinexor, to the Usual Chemotherapy Treatment (Temozolomide) for Brain Tumors That Have Returned After Previous Treatment

Recruiting
NCT02343042Phase 1

Selinexor and Backbone Treatments of Multiple Myeloma Patients

Active Not Recruiting
NCT07554482Phase 2

Selinexor Combined With Reduced-Dose Radiotherapy For Early-Stage Extranodal NK/T-Cell Lymphoma

Not Yet Recruiting
NCT04898894Phase 1

Study of Selinexor and Venetoclax in Combination With Chemotherapy in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia

Active Not Recruiting
NCT05611931Phase 3

Selinexor in Maintenance Therapy After Systemic Therapy for Participants With p53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma

Recruiting
NCT06552559Phase 1

Selinexor With ICE Chemotherapy in Secondary Central Nervous System Involving B-cell Non-Hodgkin Lymphoma

Recruiting
NCT06239272Phase 1

NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)

Recruiting
NCT02436707Phase 2

Novel Combination Therapy in the Treatment of Relapsed and Refractory Aggressive B-Cell Lymphoma

Active Not Recruiting
NCT03555422Phase 3

Maintenance With Selinexor/Placebo After Combination Chemotherapy in Participants With Endometrial Cancer [SIENDO]

Completed
NCT06169215Phase 2

Comparing the Combination of Selinexor-Daratumumab-Velcade-Dexamethasone (Dara-SVD) With the Usual Treatment (Dara-RVD) for High-Risk Newly Diagnosed Multiple Myeloma

Active Not Recruiting
NCT05333458Phase 2

Testing Atezolizumab With Selinexor in People ≥ 12 Years Old With Alveolar Soft Part Sarcoma, The AXIOM Trial

Recruiting
NCT04562389Phase 3

Study of Selinexor in Combination With Ruxolitinib in Myelofibrosis

Active Not Recruiting
NCT07200102Phase 1

Selinexor Maintenance Post CAR-T Cell Therapy for Multiple Myeloma

Recruiting
NCT07479979Phase 1

Study of Selinexor With Carfilzomib, Isatuximab and Dexamethasone for Patients With Relapsed and/or Refractory Multiple Myeloma

Not Yet Recruiting
NCT07447817Phase 2

Selinexor and Pacritinib in JAK Inhibitor-naïve MF Patients With Cytopenias

Not Yet Recruiting
NCT06158841Phase 3

Study Assessing Activity of Intravenous (IV) Etentamig Monotherapy Versus Standard Available Therapies in Adult Participants With Relapsed or Refractory Multiple Myeloma

Recruiting
NCT04925193Phase 2

Personalized Selinexor-based Therapy for Relapsed/Refractory Multiple Myeloma

Active Not Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
137