Success Metrics

Clinical Success Rate
93.3%

Based on 28 completed trials

Completion Rate
93%(28/30)
Active Trials
9(15%)
Results Posted
25%(7 trials)
Terminated
2(3%)

Phase Distribution

Ph phase_1
2
3%
Ph phase_4
21
34%
Ph phase_3
9
15%
Ph not_applicable
5
8%
Ph phase_2
9
15%

Phase Distribution

2

Early Stage

9

Mid Stage

30

Late Stage

Phase Distribution46 total trials
Phase 1Safety & dosage
2(4.3%)
Phase 2Efficacy & side effects
9(19.6%)
Phase 3Large-scale testing
9(19.6%)
Phase 4Post-market surveillance
21(45.7%)
N/ANon-phased studies
5(10.9%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

77.8%

28 of 36 finished

Non-Completion Rate

22.2%

8 ended early

Currently Active

9

trials recruiting

Total Trials

62

all time

Status Distribution
Active(13)
Completed(28)
Terminated(8)
Other(13)

Detailed Status

Completed28
unknown13
Recruiting7
Withdrawn6
Not yet recruiting3
Terminated2

Development Timeline

Analytics

Development Status

Total Trials
62
Active
9
Success Rate
93.3%
Most Advanced
Phase 4

Trials by Phase

Phase 12 (4.3%)
Phase 29 (19.6%)
Phase 39 (19.6%)
Phase 421 (45.7%)
N/A5 (10.9%)

Trials by Status

completed2845%
withdrawn610%
unknown1321%
enrolling_by_invitation12%
not_yet_recruiting35%
recruiting711%
terminated23%
active_not_recruiting23%

Recent Activity

Clinical Trials (62)

Showing 20 of 62 trialsScroll for more
NCT07341893Not Applicable

Sacubitril-valsartan in Patients With Heart Failure.

Completed
NCT04498780

Hemodynamic Effects of ARNI on Noninvasive Pressure-volume Analysis in Patients With Chronic Heart Failure

Completed
NCT05168787

Efficacy and Safety of Sacubitril/Valsartan in African American Patients With Heart Failure With Reduced Ejection Fraction

Completed
NCT05194111Phase 1

Treating Heart Dysfunction Related to Cancer Therapy With Sacubitril/Valsartan

Recruiting
NCT06536309Phase 4

Neprilysin Inhibition to Reduce Myocardial Fibrosis in Heart Failure With Preserved Ejection Fraction

Not Yet Recruiting
NCT05528419Phase 4

Sacubitril Valsartan in Preventing the Recurrence of Atrial Fibrillation After Ablation in Elderly Hypertensive Patients With Atrial Fibrillation

Completed
NCT06142383Phase 2

A Proof of Concept and Dose-finding Study of XXB750 in Patients With Heart Failure

Terminated
NCT05991284Phase 4

Sacubitril-Valsartan in Heart Failure With Preserved Ejection Fraction and Secondary Mitral Valve Regurgitation

Active Not Recruiting
NCT05498181Phase 2

Angiotensin-Neprilysin Inhibition in Hemodialysis Initiation

Recruiting
NCT05989503Phase 4

Initiation of ARNi and SGLT2i in Patients With HFrEF

Completed
NCT04023227Phase 4

Efficacy and Safety of Sacubitril/Valsartan Compared With Enalapril on Morbidity, Mortality, and NT-proBNP Change in Patients With CCC

Completed
NCT06149104Phase 3

A Safety Study of Sacubitril/Valsartan in Japanese Pediatric Patients With Heart Failure Due to Systemic Left Ventricle Systolic Dysfunction Who Have Completed CLCZ696B2319E1 Study

Completed
NCT05279742Phase 1

Enhancing the Natriuretic Peptide System in HFpEF

Enrolling By Invitation
NCT07192341Not Applicable

Sacubitril/Valsartan in Patients With Prosthetic Heart Valves With Heart Failure and Reduced Ejection Fraction

Recruiting
NCT06917664Phase 4

Treatment of Moderate Ischemic Mitral Regurgitation in Patients With Coronary Artery Disease

Recruiting
NCT03785405Phase 3

Open-label Extension Study to Evaluate Long-term Safety of Sacubitril/Valsartan in Pediatric Patients With HF

Completed
NCT05465031Phase 4

Sacubitril/Valsartan in PriMAry preventIoN of the Cardiotoxicity of Systematic breaST canceR trEAtMent (MAINSTREAM)

Recruiting
NCT03988634Phase 3

Changes in NT-proBNP, Safety, and Tolerability in HFpEF Patients With a WHF Event (HFpEF Decompensation) Who Have Been Stabilized and Initiated at the Time of or Within 30 Days Post-decompensation (PARAGLIDE-HF)

Completed
NCT04637152Phase 2

Sacubitril/Valsartan in Resistant Hypertension

Completed
NCT03760588Phase 2

Prevention of Cardiac Dysfunction During Breast Cancer Therapy

Completed

Drug Details

Intervention Type
DRUG
Total Trials
62