Success Metrics

Clinical Success Rate
68.2%

Based on 88 completed trials

Completion Rate
68%(88/129)
Active Trials
106(38%)
Results Posted
102%(90 trials)
Terminated
41(15%)

Phase Distribution

Ph phase_1
102
36%
Ph phase_4
11
4%
Ph not_applicable
2
1%
Ph early_phase_1
2
1%
Ph phase_3
30
11%
Ph phase_2
117
42%

Phase Distribution

104

Early Stage

117

Mid Stage

41

Late Stage

Phase Distribution264 total trials
Early Phase 1First-in-human
2(0.8%)
Phase 1Safety & dosage
102(38.6%)
Phase 2Efficacy & side effects
117(44.3%)
Phase 3Large-scale testing
30(11.4%)
Phase 4Post-market surveillance
11(4.2%)
N/ANon-phased studies
2(0.8%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

64.2%

88 of 137 finished

Non-Completion Rate

35.8%

49 ended early

Currently Active

106

trials recruiting

Total Trials

281

all time

Status Distribution
Active(119)
Completed(88)
Terminated(49)
Other(25)

Detailed Status

Completed88
Recruiting67
Terminated41
Active, not recruiting39
unknown25
Not yet recruiting12

Development Timeline

Analytics

Development Status

Total Trials
281
Active
106
Success Rate
68.2%
Most Advanced
Phase 4

Trials by Phase

Early Phase 12 (0.8%)
Phase 1102 (38.6%)
Phase 2117 (44.3%)
Phase 330 (11.4%)
Phase 411 (4.2%)
N/A2 (0.8%)

Trials by Status

not_yet_recruiting124%
recruiting6724%
terminated4115%
withdrawn83%
completed8831%
active_not_recruiting3914%
enrolling_by_invitation10%
unknown259%

Recent Activity

Clinical Trials (281)

Showing 20 of 281 trialsScroll for more
NCT07643025Phase 2

Belumosudil With Ruxolitnib as Third Line Therapy for Chronic Graft Versus Host Disease (cGvHD)

Not Yet Recruiting
NCT06991101Phase 2

Ruxolitinib With Radiation and Temozolomide Compared to Radiation and Temozolomide for Newly Diagnosed Glioblastoma

Recruiting
NCT06079879Phase 3

A Study of Bomedemstat (IMG-7289/MK-3543) Compared to Best Available Therapy (BAT) in Participants With Essential Thrombocythemia and an Inadequate Response or Intolerance of Hydroxyurea (MK-3543-006)

Active Not Recruiting
NCT04176198Phase 1

A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis

Recruiting
NCT07357727Phase 3

A Phase 3 Study of Pelabresib (DAK539) and Ruxolitinib in Myelofibrosis (MF)

Recruiting
NCT04562389Phase 3

Study of Selinexor in Combination With Ruxolitinib in Myelofibrosis

Active Not Recruiting
NCT04455841Phase 1

INCB000928 Administered as a Monotherapy or in Combination With Ruxolitinib in Participants With Anemia Due to Myeloproliferative Disorders

Completed
NCT07521046Phase 1

Tolerability of Ropeginterferon Alfa-2b Add-on to Ongoing Ruxolitinib Therapy in Myelofibrosis

Recruiting
NCT05592015Phase 2

Ruxolitinib for the Treatment of T-Cell Large Granular Lymphocytic Leukemia

Recruiting
NCT07849231Phase 1

Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of Mutant Calreticulin Targeted Antibodies in CALR-mutant Myeloproliferative Neoplasms

Recruiting
NCT07722611Phase 2

A Clinical Trial of Bomedemstat in Participants With Polycythemia Vera (MK-3543-025)

Recruiting
NCT05548062

Study to Identify and Describe Predictive Factors for Thromboembolic Events in Patients With High-risk Polycythemia Vera

Active Not Recruiting
NCT06150157Phase 1

A Study of JNJ-88549968 for the Treatment of Calreticulin (CALR)-Mutated Myeloproliferative Neoplasms

Recruiting
NCT07840456Phase 2

Safety and Efficacy of Ruxolitinib in Patients With HNSCC and High NLR Treated With Pembrolizumab - The Phase 2 InflammaSTOP Trial

Not Yet Recruiting
NCT06120140Phase 2

Enhanced Dermatological Care to Reduce Rash and Paronychia in Epidermal Growth Factor Receptor (EGRF)-Mutated Non-Small Cell Lung Cancer (NSCLC) Treated First-line With Amivantamab Plus Lazertinib

Active Not Recruiting
NCT03874052Phase 1

Ruxolitinib in Combination With Venetoclax With and Without Azacitidine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

Recruiting
NCT02974647Phase 2

Study of Ruxolitinib in Relapsed or Refractory T or NK Cell Lymphoma

Recruiting
NCT04744116Early Phase 1

Addition of Cord Blood Tissue-Derived Mesenchymal Stromal Cells to Ruxolitinib for the Treatment of Steroid-Refractory Acute Graft Versus Host Disease

Recruiting
NCT07025538Phase 1

Biomarker-Guided Ruxolitinib for the Prevention of Chronic Graft Versus Host Disease After Allogeneic Hematopoietic Cell Transplantation

Recruiting
NCT06160791Phase 2

Ruxolitinib With De-Intensified HLH-94 for the Treatment of Hemophagocytic Lymphohistiocytosis (HLH)

Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
281