Success Metrics

Clinical Success Rate
75.0%

Based on 3 completed trials

Completion Rate
75%(3/4)
Active Trials
5(50%)
Results Posted
0%(0 trials)
Terminated
1(10%)

Phase Distribution

Ph phase_2
3
30%
Ph phase_3
1
10%
Ph phase_1
5
50%

Phase Distribution

5

Early Stage

3

Mid Stage

1

Late Stage

Phase Distribution9 total trials
Phase 1Safety & dosage
5(55.6%)
Phase 2Efficacy & side effects
3(33.3%)
Phase 3Large-scale testing
1(11.1%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

75.0%

3 of 4 finished

Non-Completion Rate

25.0%

1 ended early

Currently Active

5

trials recruiting

Total Trials

10

all time

Status Distribution
Active(5)
Completed(3)
Terminated(1)
Other(1)

Detailed Status

Recruiting4
Completed3
unknown1
Active, not recruiting1
Terminated1

Development Timeline

Analytics

Development Status

Total Trials
10
Active
5
Success Rate
75.0%
Most Advanced
Phase 3

Trials by Phase

Phase 15 (55.6%)
Phase 23 (33.3%)
Phase 31 (11.1%)

Trials by Status

recruiting440%
unknown110%
active_not_recruiting110%
terminated110%
completed330%

Recent Activity

Clinical Trials (10)

Showing 10 of 10 trials
NCT06552234Phase 2

Phase II Efficacy Study of Repotrectinib in Frail and/or Elderly Patients With ROS1-rearranged Advanced NSCLC

Recruiting
NCT07223671Phase 1

Study to Evaluate the Effect of Repotrectinib on the Drug Levels of Transporter and CYP P450 Probe Substrates in Healthy Adult Participants

Completed
NCT05004116Phase 1

A Study of Repotrectinib in Combination With Chemotherapy in Children and Young Adults With Solid Tumor Cancer

Recruiting
NCT06315010Phase 2

REPotrectinib in ROS1-positive Non-small Cell Lung Cancer Patients With Active Brain mEtastasis

Recruiting
NCT06408168Phase 2

Phase II Study of REPotrectinib With or Without Fulvestrant in Patients With Hormone Receptor-positive Human Epidermal Growth Factor 2-negative Metastatic Invasive LObular Carcinoma Who Received a Prior Endocrine Therapy in Combination With Cyclin-dependent Kinase 4 and 6 Inhibitor (REPLOT Trial)

Terminated
NCT06140836Phase 3

A Study of Repotrectinib Versus Crizotinib in Participants With Locally Advanced or Metastatic Tyrosine Kinase Inhibitor (TKI)-naïve ROS1-positive Non-Small Cell Lung Cancer (NSCLC) (TRIDENT-3)

Active Not Recruiting
NCT06352528Phase 1

A Study to Assess the Drug Levels of Repotrectinib in Healthy Participants and Participants With Moderate and Severe Hepatic Impairment

Completed
NCT06493409Phase 1

A Study to Assess the Effect of Voriconazole and Quinidine on the Pharmacokinetics of a Single Dose of Repotrectinib in Healthy Participants

Completed
NCT04772235Phase 1

Phase I Study of Repotrectinib and Osimertinib in NSCLC Patients

Recruiting
NCT05926232

Expanded Access for Repotrectinib

Unknown

All 10 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
10