Success Metrics

Clinical Success Rate
100.0%

Based on 19 completed trials

Completion Rate
100%(19/19)
Active Trials
1(5%)
Results Posted
26%(5 trials)

Phase Distribution

Ph early_phase_1
1
5%
Ph phase_3
2
9%
Ph not_applicable
3
14%
Ph phase_2
2
9%
Ph phase_4
1
5%
Ph phase_1
13
59%

Phase Distribution

14

Early Stage

2

Mid Stage

3

Late Stage

Phase Distribution22 total trials
Early Phase 1First-in-human
1(4.5%)
Phase 1Safety & dosage
13(59.1%)
Phase 2Efficacy & side effects
2(9.1%)
Phase 3Large-scale testing
2(9.1%)
Phase 4Post-market surveillance
1(4.5%)
N/ANon-phased studies
3(13.6%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

90.5%

19 of 21 finished

Non-Completion Rate

9.5%

2 ended early

Currently Active

1

trials recruiting

Total Trials

22

all time

Status Distribution
Active(1)
Completed(19)
Terminated(2)

Detailed Status

Completed19
Withdrawn2
Recruiting1

Development Timeline

Analytics

Development Status

Total Trials
22
Active
1
Success Rate
100.0%
Most Advanced
Phase 4

Trials by Phase

Early Phase 11 (4.5%)
Phase 113 (59.1%)
Phase 22 (9.1%)
Phase 32 (9.1%)
Phase 41 (4.5%)
N/A3 (13.6%)

Trials by Status

recruiting15%
withdrawn29%
completed1986%

Recent Activity

1 active trials
Showing 5 of 22
completedearly_phase_1

Pyrimethamine as an Inhibitor of NRF2 in HPV-unrelated Locally Advanced Head and Neck Squamous Cell Carcinoma

NCT05678348
completedphase_1

Pyrimethamine for the Treatment of Relapsed Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

NCT01066663
completedphase_1

Sanaria PfSPZ Challenge With Pyrimethamine or Chloroquine Chemoprophylaxis Vaccination (PfSPZ-CVac Approach): A Randomized Double Blind Placebo Controlled Phase I/II Trial to Determine Safety and Protective Efficacy Against Natural Plasmodium Falcipa...

NCT03952650
completedphase_1

A Study of Pyrimethamine in the Treatment of Infection by a Certain Parasite in HIV-Positive Patients

NCT00000973
completedphase_3

A Controlled Comparative Trial of Sulfamethoxazole-Trimethoprim Versus Aerosolized Pentamidine for Secondary Prophylaxis of Pneumocystis Carinii Pneumonia in AIDS Patients Receiving Azidothymidine (AZT)

NCT00000727
View all 22 trials

Clinical Trials (22)

Showing 20 of 22 trialsScroll for more
NCT05678348Early Phase 1

Pyrimethamine as an Inhibitor of NRF2 in HPV-unrelated Locally Advanced Head and Neck Squamous Cell Carcinoma

Completed
NCT01066663Phase 1

Pyrimethamine for the Treatment of Relapsed Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Completed
NCT03952650Phase 1

Sanaria PfSPZ Challenge With Pyrimethamine or Chloroquine Chemoprophylaxis Vaccination (PfSPZ-CVac Approach): A Randomized Double Blind Placebo Controlled Phase I/II Trial to Determine Safety and Protective Efficacy Against Natural Plasmodium Falcipa...

Completed
NCT00000973Phase 1

A Study of Pyrimethamine in the Treatment of Infection by a Certain Parasite in HIV-Positive Patients

Completed
NCT00000727Phase 3

A Controlled Comparative Trial of Sulfamethoxazole-Trimethoprim Versus Aerosolized Pentamidine for Secondary Prophylaxis of Pneumocystis Carinii Pneumonia in AIDS Patients Receiving Azidothymidine (AZT)

Completed
NCT00000643Phase 2

Primary Prophylaxis of Cerebral Toxoplasmosis in HIV-Infected Patients

Completed
NCT00000794Phase 2

Phase II Randomized Open-Label Trial of Atovaquone Plus Pyrimethamine and Atovaquone Plus Sulfadiazine for the Treatment of Acute Toxoplasmic Encephalitis

Completed
NCT03057990Phase 1

Pyrimethamine for Intermediate/High-risk Myelodysplastic Syndromes (MDS)

Withdrawn
NCT03083847Phase 1

Dose Escalation PfSPZ-CVac

Completed
NCT03525730Phase 1

LRAs United as a Novel Anti-HIV Strategy.

Completed
NCT04086719Phase 1

An Investigational Study to Determine the Drug Level Profile of BMS-986165 in Healthy Male Volunteers Following Transporter Inhibition.

Completed
NCT03258762Phase 1

Phase I Study of Pyrimethamine in Healthy Japanese and Caucasian Subjects

Completed
NCT01083667Phase 1

SOD1 Inhibition by Pyrimethamine in Familial Amyotrophic Lateral Sclerosis (ALS)

Completed
NCT00679744Phase 1

A Phase I Study of Pyrimethamine in Patients With GM2 Gangliosidosis

Withdrawn
NCT00000666Not Applicable

A Randomized Prospective Study of Pyrimethamine Therapy for Prevention of Toxoplasmic Encephalitis in HIV-Infected Individuals With Serologic Evidence of Latent Toxoplasma Gondii Infection

Completed
NCT00000674Not Applicable

A Pilot Study of Oral Clindamycin and Pyrimethamine for the Treatment of Toxoplasmic Encephalitis in Patients With AIDS

Completed
NCT01102686Phase 1

Pyrimethamine as a Treatment for Late-Onset GM2-gangliosidosis (Tay-Sachs and Sandhoff Disease)

Completed
NCT00004317Phase 4

Pyrimethamine, Sulfadiazine, and Leucovorin in Treating Patients With Congenital Toxoplasmosis

Recruiting
NCT00000966Phase 1

A Study of Azithromycin Plus Pyrimethamine in the Treatment of a Brain Infection in Patients With AIDS

Completed
NCT00065390Phase 1

Pyrimethamine to Treat Autoimmune Lymphoproliferative Syndrome

Completed

Drug Details

Intervention Type
DRUG
Total Trials
22