Success Metrics

Clinical Success Rate
91.9%

Based on 34 completed trials

Completion Rate
92%(34/37)
Active Trials
5(10%)
Results Posted
65%(22 trials)
Terminated
3(6%)

Phase Distribution

Ph phase_1
12
24%
Ph not_applicable
2
4%
Ph phase_2
9
18%
Ph phase_3
11
22%
Ph phase_4
8
16%
Ph early_phase_1
1
2%

Phase Distribution

13

Early Stage

9

Mid Stage

19

Late Stage

Phase Distribution43 total trials
Early Phase 1First-in-human
1(2.3%)
Phase 1Safety & dosage
12(27.9%)
Phase 2Efficacy & side effects
9(20.9%)
Phase 3Large-scale testing
11(25.6%)
Phase 4Post-market surveillance
8(18.6%)
N/ANon-phased studies
2(4.7%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

85.0%

34 of 40 finished

Non-Completion Rate

15.0%

6 ended early

Currently Active

5

trials recruiting

Total Trials

49

all time

Status Distribution
Active(6)
Completed(34)
Terminated(6)
Other(3)

Detailed Status

Completed34
Recruiting5
Withdrawn3
Terminated3
unknown3
Not yet recruiting1

Development Timeline

Analytics

Development Status

Total Trials
49
Active
5
Success Rate
91.9%
Most Advanced
Phase 4

Trials by Phase

Early Phase 11 (2.3%)
Phase 112 (27.9%)
Phase 29 (20.9%)
Phase 311 (25.6%)
Phase 48 (18.6%)
N/A2 (4.7%)

Trials by Status

completed3469%
recruiting510%
not_yet_recruiting12%
withdrawn36%
terminated36%
unknown36%

Recent Activity

Clinical Trials (49)

Showing 20 of 49 trialsScroll for more
NCT07155226Phase 1

Study of AZD3632 Monotherapy or in Combination With Anticancer Agents in Participants With Advanced Haematologic Malignancies With KMT2Ar, NPM1m, or Other Genotypes Associated With HOX Overexpression

Recruiting
NCT04771130Phase 1

A Study of BGB-11417 in Participants With Myeloid Malignancies

Recruiting
NCT04368559Phase 3

Study of Rezafungin Compared to Standard Antimicrobial Regimen for Prevention of Invasive Fungal Diseases in Adults Undergoing Allogeneic Blood and Marrow Transplantation

Completed
NCT06802757Phase 2

Posaconazole Plus PD-1 Inhibitors and Chemotherapy vs PD-1 Inhibitors and Chemotherapy in Neoadjuvant Therapy for Triple Negative Breast Cancer

Recruiting
NCT07261150Phase 3

Histoplasmosis Induction and Consolidation Therapy Factorial Randomized Clinical Trial (Histo-FACT)

Not Yet Recruiting
NCT06541067Phase 2

Study of Posaconazole Prophylaxis in Patients Receiving Hematopoietic Stem Cell Allograft (Allo-HSC) at High Risk of Invasive Fungal Infection (IFI)

Recruiting
NCT04294641Phase 2

Front Line Ibrutinib Without Corticosteroids for Newly Diagnosed Chronic Graft-versus-Host Disease

Completed
NCT03828773Not Applicable

PTX3-targeted Antifungal Prophylaxis

Recruiting
NCT05065658

Posaconazole Prophylaxis for CAPA Prevention in Critically-Ill Patients

Completed
NCT03318159Phase 2

Posaconazole Prophylaxis During ATG Treatment for hMDS/AA Patients

Completed
NCT03066011

Registry of Patients Treated With Systemic Mold-Active Triazoles

Completed
NCT01782131Phase 3

A Study of the Safety and Efficacy of Posaconazole Versus Voriconazole for the Treatment of Invasive Aspergillosis (MK-5592-069)

Completed
NCT02203773Phase 1

Study of ABT-199 (GDC-0199) in Combination With Azacitidine or Decitabine (Chemo Combo) in Subjects With Acute Myelogenous Leukemia (AML)

Terminated
NCT03796533Not Applicable

Pharmacokinetics Variability of Posaconazole (PCZ) and Its Glucuronide Metabolite During Induction and Consolidation Treatments in Patients With Acute Myeloid Leukemia (AML): a Covariate Analysis With the Tablets Formulation and Evaluation of the Potential Risk of Hepatotoxicity

Unknown
NCT02180165Phase 3

Assessing the Safety and Efficacy of MK-5592 (Posaconazole) in Japanese Participants With Fungal Infection (MK-5592-101)

Completed
NCT02358499Phase 1

Genetic Variation and Variability in Posaconazole Pharmacokinetics in Children

Completed
NCT00817765Phase 1

Pharmacokinetic Study of Posaconazole Boosted Fosamprenavir

Completed
NCT03421366

Modified Release Posaconazole in Patients With Cystic Fibrosis

Unknown
NCT02875743Phase 4

King's Invasive Aspergillosis Study II

Completed
NCT03760445Phase 1

HDM201 Added to CT in R/R or Newly Diagnosed AML

Withdrawn

Drug Details

Intervention Type
DRUG
Total Trials
49